Engineer enzyme nanoparticles as antibiotic alternatives for agriculture

设计酶纳米颗粒作为农业抗生素替代品

• 批准号: DP210103595
• 负责人: A/Prof Victoria Haritos
• 金额: $ 20.64万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-11-09 至 2024-11-08
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103595
• 关键词: Engineer; enzyme; nanoparticles; antibiotic; alternatives

Antibiotic usage in agriculture contributes to spread of resistant bacteria. Existing antibiotic alternatives to minimize such usage are focused on growth promotion of animals and infection prevention, but lack efficient treatment. This project aims to engineer enzyme nanoparticles, with synergy from multiple enzymes, to confer better antibacterial abilities against livestock pathogens. It will combine protein engineering, nanotechnology and biophysics to develop new enzyme nanoparticles that can be manufactured at low-cost through self-assembly process. The intended outcome is knowledge on molecular engineering of enzyme nanoparticles and innovative agriculture biotechnology for treatment of bacterial infectious diseases in livestock.

农业中抗生素的使用有助于耐药细菌的传播。现有的抗生素替代品，以尽量减少这种使用的重点是促进动物的生长和感染预防，但缺乏有效的治疗。该项目旨在设计酶纳米颗粒，与多种酶协同作用，以赋予对牲畜病原体更好的抗菌能力。它将联合收割机结合蛋白质工程、纳米技术和生物物理学，开发出可以通过自组装过程低成本制造的新型酶纳米颗粒。预期的成果是酶纳米颗粒的分子工程和创新的农业生物技术治疗牲畜细菌传染病的知识。