Epidemioloical study on platelet aggregation and risk of stroke and coronary heart disease

血小板聚集与中风、冠心病风险的流行病学研究

• 批准号: 09470108
• 负责人: ISO Hiroyasu
• 金额: $ 5.18万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470108/
• 关键词: Platelet aggregation; Serun fatty acid composition; Fish intake; Risk factors; Cardiovascular disease

To investigate the contribution of the platelet aggregation in the development of cardiovascular diseases, we examined the relation of constitutional and lifestyle variables with platelet aggregation for a total of 306 males aged 50 to 70 in Ikawa town of Akita prefecture (n=163), Noichi town of Kochi prefecture (n= 143) and Kyowa twon of Ibaraki prefecture (n=142). Mean logarithmic transformed PATI (log PATI) was higher in Ikawa than in Noichi and Ibaraki. Thus platelet aggregation was lower in Ikawa than in the other populations. According to multiple regression analysis, age, platelet count in platelet rich plasma, mean platelet volume in platelet rich plasma, and white blood cell count serum arachidonic acid composition were inversely associated with log PATI.Serum n3 polyunsaturated fatty acid composition and log gamma-GTP were positively associated with log PATI.Maximum aggregation rate under ADP lmuM was found to be a comparable indicator to PATI (r = 0.9). A study of 465 men an … More d women aged 50-74 in Ibaraki showed that this indicator had similar correlates to PATI.To investigate changes in platelet function, count and metabolism following fish intake among Japanese, we conducted an experimental intervention study of seven healthy Japanese volunteers (4 males and 3 females) aged 28-58 years. We supplemented their diets with an approximate daily intake of 200-400g fish which is equivalent to about 10g n3-polyunsaturated fatty acids during the 17 days. The study continued until the 23rd day after returning to an ad lititum diet. The proportion of serum n3-polyunsaturated fatty acids three-fold during the fish supplementation, and returned to the level before fish supplementation on the 12th day after returning to an ad lititum diet. Platelet counts decreased and the mean platelet volume increased during fish supplementation. Platelet aggregation by collagen tended to decrease during fish supplementation. Mean serum triglyceride level declined and mean plasma fibrinogen tended to decline during the fish supplementation. Habitual fish intake may attenuate the development of atherosclerosis and prevent ischemic heart disease through suppression of platelet activity, and by reducing platelet counts and serum triglyceride levels.This study demonstrated feasibility of platelet aggregation test in health examination. For persons with enhanced platelet aggregation, habitual fish intake may be recommended to attenuate the development of atherosclerosis and prevent ischemic heart disease. Less

为了探讨血小板聚集在心血管疾病发展中的作用，我们对秋田县伊川镇（n=163）、高知县诺一镇（n= 143）和茨城县京和镇（n=142）共306名50 - 70岁男性的身体结构和生活方式变量与血小板聚集的关系进行了研究。平均对数变换后的PATI （log PATI）在伊川县高于Noichi和茨城县。因此，伊川人的血小板聚集比其他人群低。经多元回归分析，年龄、富血小板血浆血小板计数、富血小板血浆平均血小板体积、白细胞计数、血清花生四烯酸组成与log PATI呈负相关。血清n3多不饱和脂肪酸组成和对数γ - gtp与对数PATI呈正相关。ADP lmuM下的最大聚集率与PATI具有可比性（r = 0.9）。一项对茨城市465名50-74岁男性和50多名女性的研究表明，该指标与PATI具有相似的相关性。为了研究日本人摄入鱼类后血小板功能、计数和代谢的变化，我们对7名年龄在28-58岁的健康日本志愿者（4男3女）进行了实验性干预研究。在这17天里，我们在他们的饮食中补充了大约每天200-400g的鱼，相当于大约10g的n3-多不饱和脂肪酸。这项研究一直持续到恢复诉讼饮食后的第23天。血清n3-多不饱和脂肪酸的比例在补鱼期间增加了3倍，并在恢复正常饮食后的第12天恢复到补鱼前的水平。在补充鱼类期间，血小板计数降低，平均血小板体积增加。在补充鱼类期间，胶原蛋白的血小板聚集有减少的趋势。平均血清甘油三酯水平下降，平均血浆纤维蛋白原有下降趋势。经常吃鱼可以通过抑制血小板活性、降低血小板计数和血清甘油三酯水平来减缓动脉粥样硬化的发展，预防缺血性心脏病。本研究证实了血小板聚集试验在健康体检中的可行性。对于血小板聚集增强的人，可能建议经常摄入鱼类以减轻动脉粥样硬化的发展和预防缺血性心脏病。少

项目成果

今野弘規、磯博康、他: "地域住民における血小板凝集能と身体・生活要因との関連" 日本公衆衛生雑誌. 45.6. 536-551 (1998)

Hiroki Konno、Hiroyasu Iso 等人：“当地居民血小板聚集能力与身体和生活方式因素之间的关系”日本公共卫生杂志 45.6（1998）。

今野弘規 他: "脳梗塞、心筋梗塞の予防を目的とした血小板凝集能検査の検診への導入" 日本公衆衛生雑誌. 44.10(Suppl). 417 (1998)

Hiroki Konno等人：“将血小板聚集测试引入医学检查以预防脑梗塞和心肌梗塞”日本公共卫生杂志44.10（增刊）417（1998）。

今野弘規 他: "血小板凝集能に関与する要因の疫学的研究" 日本公衆衛生雑誌. 44.10(Suppl). 624 (1997)

Hiroki Konno 等：“血小板聚集能力相关因素的流行病学研究”日本公共卫生杂志 44.10（增刊）624（1997 年）。