Epidemioloical study on platelet aggregation and risk of stroke and coronary heart disease

为了探讨血小板聚集在心血管疾病发病中的作用，我们对秋田县池川镇(n=163)、高知县Noichi镇(n=143)和茨城县Kyowa Ton(n=142)共306名50~70岁男性的体质和生活方式变量与血小板聚集的关系进行了研究。平均对数转换PATI(对数PATI)在Ikawa高于Noichi和Ibaraki。因此，Ikawa的血小板聚集率低于其他人群。多元回归分析显示，年龄、富血小板血浆中的血小板数、平均血小板体积、白细胞计数、血清花生四烯酸组成与LOG PATI呈负相关，血清n3多不饱和脂肪酸组成、LOG-GTP与LOG PATI呈正相关，ADP下最大聚集率与LOG PATI有可比性(r=0.9)。对465名男性…患者的研究茨城50-74岁的女性较多，这一指标与PATI有类似的相关性。为了研究日本人摄入鱼类后血小板功能、计数和代谢的变化，我们对7名28-58岁的健康日本志愿者(4男3女)进行了实验干预研究。我们补充了他们的饮食，每天大约摄入200-400克鱼，相当于17天中大约10克n3-多不饱和脂肪酸。这项研究一直持续到恢复广告诉讼节食后的第23天。血清n3-多不饱和脂肪酸的比例在补充鱼的过程中增加了3倍，并在恢复特殊饮食后的第12天恢复到补充鱼前的水平。补充FISH期间，血小板计数减少，平均血小板体积增加。补充鱼肉时，胶原蛋白引起的血小板聚集率有降低的趋势。在鱼的补充过程中，平均血清甘油三酯水平和平均血浆纤维蛋白原水平呈下降趋势。习惯性摄入鱼类可能通过抑制血小板活性，降低血小板计数和血清甘油三酯水平，从而延缓动脉粥样硬化的发展，预防缺血性心脏病。对于血小板聚集增强的人，建议经常摄入鱼类，以减缓动脉粥样硬化的发展，预防缺血性心脏病。较少

To investigate the contribution of the platelet aggregation in the development of cardiovascular diseases, we examined the relation of constitutional and lifestyle variables with platelet aggregation for a total of 306 males aged 50 to 70 in Ikawa town of Akita prefecture (n=163), Noichi town of Kochi prefecture (n= 143) and Kyowa twon of Ibaraki prefecture (n=142). Mean logarithmic transformed PATI (log PATI) was higher in Ikawa than in Noichi and Ibaraki. Thus platelet aggregation was lower in Ikawa than in the other populations. According to multiple regression analysis, age, platelet count in platelet rich plasma, mean platelet volume in platelet rich plasma, and white blood cell count serum arachidonic acid composition were inversely associated with log PATI.Serum n3 polyunsaturated fatty acid composition and log gamma-GTP were positively associated with log PATI.Maximum aggregation rate under ADP lmuM was found to be a comparable indicator to PATI (r = 0.9). A study of 465 men an … More d women aged 50-74 in Ibaraki showed that this indicator had similar correlates to PATI.To investigate changes in platelet function, count and metabolism following fish intake among Japanese, we conducted an experimental intervention study of seven healthy Japanese volunteers (4 males and 3 females) aged 28-58 years. We supplemented their diets with an approximate daily intake of 200-400g fish which is equivalent to about 10g n3-polyunsaturated fatty acids during the 17 days. The study continued until the 23rd day after returning to an ad lititum diet. The proportion of serum n3-polyunsaturated fatty acids three-fold during the fish supplementation, and returned to the level before fish supplementation on the 12th day after returning to an ad lititum diet. Platelet counts decreased and the mean platelet volume increased during fish supplementation. Platelet aggregation by collagen tended to decrease during fish supplementation. Mean serum triglyceride level declined and mean plasma fibrinogen tended to decline during the fish supplementation. Habitual fish intake may attenuate the development of atherosclerosis and prevent ischemic heart disease through suppression of platelet activity, and by reducing platelet counts and serum triglyceride levels.This study demonstrated feasibility of platelet aggregation test in health examination. For persons with enhanced platelet aggregation, habitual fish intake may be recommended to attenuate the development of atherosclerosis and prevent ischemic heart disease. Less