Epidemioloical study on platelet aggregation and risk of stroke and coronary heart disease

为探讨血小板聚集在心血管疾病发生中的作用，我们对秋田县伊川町（n=163）、高知县野市町（n = 143）和茨木县协和町（n=142）共306名50 - 70岁男性进行了体质和生活方式变量与血小板聚集的关系的研究。Ikawa的平均对数转换帕蒂（log帕蒂）高于Noichi和茨木。因此，Ikawa的血小板聚集率低于其他人群。多元回归分析显示，年龄、富血小板血浆中血小板计数、富血小板血浆中平均血小板体积、结果表明，血白细胞计数、血清花生四烯酸组成与log帕蒂呈负相关，血清n3多不饱和脂肪酸组成、log γ-GTP与log帕蒂呈正相关，ADP 1 μ M下的最大聚集率与帕蒂具有可比性（r = 0.9）。一项针对465名男性的研究， 关于我们 为了研究日本人吃鱼后血小板功能、数量和代谢的变化，我们对7名年龄在28-58岁的健康日本志愿者（4男3女）进行了实验性干预研究。我们补充他们的饮食与约200- 400克鱼的每日摄入量，相当于约10克的n3-多不饱和脂肪酸在17天。研究持续到恢复自由饮食后的第23天。血清n3-多不饱和脂肪酸的比例在补鱼期间增加了3倍，在恢复自由采食后的第12天恢复到补鱼前的水平。在补充鱼类期间，血小板计数减少，平均血小板体积增加。胶原蛋白引起的血小板聚集在补充鱼类期间趋于减少。平均血清甘油三酯水平下降，平均血浆纤维蛋白原趋于下降，在鱼的补充。常食鱼类可通过抑制血小板活性、降低血小板计数和血清甘油三酯水平，从而减轻动脉粥样硬化的发展，预防缺血性心脏病，本研究证实了血小板聚集试验在健康体检中的可行性。对于血小板聚集增强的人，可以建议习惯性摄入鱼类，以减轻动脉粥样硬化的发展，预防缺血性心脏病。少

To investigate the contribution of the platelet aggregation in the development of cardiovascular diseases, we examined the relation of constitutional and lifestyle variables with platelet aggregation for a total of 306 males aged 50 to 70 in Ikawa town of Akita prefecture (n=163), Noichi town of Kochi prefecture (n= 143) and Kyowa twon of Ibaraki prefecture (n=142). Mean logarithmic transformed PATI (log PATI) was higher in Ikawa than in Noichi and Ibaraki. Thus platelet aggregation was lower in Ikawa than in the other populations. According to multiple regression analysis, age, platelet count in platelet rich plasma, mean platelet volume in platelet rich plasma, and white blood cell count serum arachidonic acid composition were inversely associated with log PATI.Serum n3 polyunsaturated fatty acid composition and log gamma-GTP were positively associated with log PATI.Maximum aggregation rate under ADP lmuM was found to be a comparable indicator to PATI (r = 0.9). A study of 465 men an … More d women aged 50-74 in Ibaraki showed that this indicator had similar correlates to PATI.To investigate changes in platelet function, count and metabolism following fish intake among Japanese, we conducted an experimental intervention study of seven healthy Japanese volunteers (4 males and 3 females) aged 28-58 years. We supplemented their diets with an approximate daily intake of 200-400g fish which is equivalent to about 10g n3-polyunsaturated fatty acids during the 17 days. The study continued until the 23rd day after returning to an ad lititum diet. The proportion of serum n3-polyunsaturated fatty acids three-fold during the fish supplementation, and returned to the level before fish supplementation on the 12th day after returning to an ad lititum diet. Platelet counts decreased and the mean platelet volume increased during fish supplementation. Platelet aggregation by collagen tended to decrease during fish supplementation. Mean serum triglyceride level declined and mean plasma fibrinogen tended to decline during the fish supplementation. Habitual fish intake may attenuate the development of atherosclerosis and prevent ischemic heart disease through suppression of platelet activity, and by reducing platelet counts and serum triglyceride levels.This study demonstrated feasibility of platelet aggregation test in health examination. For persons with enhanced platelet aggregation, habitual fish intake may be recommended to attenuate the development of atherosclerosis and prevent ischemic heart disease. Less