Blood homoysteine, its associated factors, atheroscerosis and cardiovasular desease

血液同型半胱氨酸及其相关因素、动脉粥样硬化与心血管疾病

• 批准号: 11470103
• 负责人: ISO Hiroyasu
• 金额: $ 9.66万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470103/
• 关键词: Homoysteine; Carotid atherosclerosis; Folate; Vitamins B; Genetic polymorphisms; Epidemiologic studies

We have conducted cross-sectional and prospective nested-case control studies to investigate associated factors for blood homocysteine, the relation between homocysteine and carotid atherosclerosis, and the relation between homocysteine and the risk of stroke and coronary heart disease. The subjects were 3,071 men and women aged 40-79 in Ibaraki rural community and 965 participants aged 20-74 in clinic health examination of Kochi for a cross-sectional study. Associated factors for high blood homocysteine concentrations were low serum concentrations of folate and low vitamin B12 and low dietary intakes of vegetables, seaweed and fishAssociated factors for homocysteine were age, hypertension, body mass index, and cigarette smoking. Age-adjusted plasma homocysteine levels were higher for both men and women with the homozygous genotype for the mutation than those who were heterozygous or had no mutation. Elevated homocysteine levels in homozygous genotype was attenuated among persons with … More higher serum levels of vitamin B12 and folate, but not vitamin B6, and among persons with the combination of lower folate and higher vitamin B12 and of higher folate and higher vitamin B12, split by the median. Thus, elevated homocysteine levels among Japanese with the homozygous genotype for the MTHFR gene mutation can be modified efficiently by dietary supplement of vitamin B12 as well as folate.A prospective nested case-control study was conducted using frozen serum samples from 7,450 participants in cardiovascular risk surveys, collected from 1984-1989 for one community and 1989-1992 for the other two communities. We identified 74 incident strokes whose subtypes were confirmed by imaging studies. Three controls per case were selected by matching for sex, age, community, year of serum storage and fasting status. The multivariate odds ratio of total stroke for highest vs lowest quartiles of serum homocysteine was 2.6 (1.0, 6.6), P = 0.04. We found that high homocystens predicted the risk of total stroke among Japanese. Less

我们进行了横断面和前瞻性巢式病例对照研究，以调查血同型半胱氨酸的相关因素，同型半胱氨酸与颈动脉粥样硬化的关系，以及同型半胱氨酸与中风和冠心病风险的关系。研究对象为茨城县农村社区3071名40 ~ 79岁的男女和高知县临床健康体检的965名20 ~ 74岁的参与者，采用横断面研究。与高血同型半胱氨酸浓度相关的因素是血清叶酸浓度低、维生素B12含量低以及饮食中蔬菜、海藻和鱼类摄入量低。与高血同型半胱氨酸浓度相关的因素是年龄、高血压、体重指数和吸烟。纯合子基因型突变的男性和女性的年龄调整血浆同型半胱氨酸水平都高于杂合子或无突变的男性和女性。在血清中维生素B12和叶酸水平较高但维生素B6水平不高的人群中，在低叶酸和高维生素B12组合以及高叶酸和高维生素B12组合的人群中，纯合子基因型的同型半胱氨酸水平升高被中位数分割。因此，MTHFR基因突变纯合子基因型的日本人高同型半胱氨酸水平可以通过补充维生素B12和叶酸有效地改善。一项前瞻性巢式病例对照研究使用心血管风险调查中7450名参与者的冷冻血清样本进行，这些样本收集于1984-1989年的一个社区和1989-1992年的另外两个社区。我们确定了74例卒中，其亚型经影像学检查证实。根据性别、年龄、社区、血清储存年份和禁食情况匹配，每例选择3例对照。血清同型半胱氨酸最高和最低四分位数的总卒中的多因素优势比为2.6 (1.0,6.6),P = 0.04。我们发现高同型系统预测了日本人中风的风险。少

项目成果

Moriyama Y, et al: "Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate reductase gene in Japanese"Atherosclerosis 2002. (in press).

Moriyama Y 等人：“日本人血清 B 族维生素对与亚甲基四氢叶酸还原酶基因突变相关的血浆同型半胱氨酸水平升高的影响”，动脉粥样硬化 2002 年。（出版中）。

Moriyama Y, et al: "Effects of seram B vitamins on elevated plasma homocysteine levels associated with the mutation of melthylonetetrahydrofolate reductase gene"J. Epidemiol 2001. 11.1 (suppl). 136

Moriyama Y 等人：“血清 B 族维生素对与甲基四氢叶酸还原酶基因突变相关的血浆同型半胱氨酸水平升高的影响”J.

Moriyama Y, et al.: "Effects of serum B vitamins on elevated plasma homoysteine levels associated with the mutation of methylenetetiahydrofo late reduction gene in Japanese"Atherosclerosis. (in press). (2002)

Moriyama Y 等人：“血清 B 族维生素对日本人与亚甲基氢叶酸还原基因突变相关的血浆高半胱氨酸水平升高的影响”动脉粥样硬化。

Moriyama Y, et al.: "Effects of serum B vitamins on elevated plasma homocysteine lelvels associated with the mutation of methylenetetra hydrofolate reductase gene in Japanese"J. Epidemiol. 11・1(Suppl). 136 (2001)

Moriyama Y等人：“血清B族维生素对与日本亚甲基四氢叶酸还原酶基因突变相关的血浆同型半胱氨酸水平升高的影响”J. Epidemiol 11・1（增刊）。

Moriyama Y, et al.: "Effects of serum B vitamins on elevated plasma homocysteine levels associated with the moutation of methylenetetrahydrofolate reductase gene in Japanese"J. Epidemiol. 11.1(Suppl). 136 (2001)

Moriyama Y 等人：“血清 B 族维生素对日语中与亚甲基四氢叶酸还原酶基因突变相关的血浆同型半胱氨酸水平升高的影响”J.