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A Community-Based Study on the Type of Stroke Determined by CT Scan and Their Risk Factors

CT 扫描确定中风类型及其危险因素的社区研究

基本信息

批准号：
01480201
负责人：
ISO Hiroyasu
金额：
$ 3.33万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

项目摘要

Although mortality and morbidity of stroke have declined in Japan, stroke is a leading cause of physical and metal disability. Because of a wide use of computerized tomography (CT scan), stroke with small hemorrhage is likely to be detected although the incidence of cerebral hemorrhage declined along with hypertension control and improvements of lifestyle. According to clinical reports, the number of cerebral infraction in cortical artery regions, mostly thrombotic infraction, are increasing. However, few community-based study was conducted to clarify the prevalence of the type of stroke and their risk factors in our country. Recent wide use of CT scan enabled us to conduct the community-based study. The survey communities were two rural populations in northeast Japan and a rural population in central japan. Census populations in 1990 were 3,000, 7,000 and 17,000, respectively. Among 203 stroke cases of men and women aged 40 and over in three communities, 142 had the examination of CT scan For 142 stroke cases, the prevalence of the type of stroke was tabulated according to sex and age. Prevalences of cerebral hemorrhage and penetrating artery infraction were higher in Japan than in the U. S. and European countries. The opposite trend was observed in the prevalence of cortical artery infarction. To examine risk factors of the type of stroke, a nested-case control study was conducted. Addition to previous epidemiologic findings, a positive association between hypertension and penetrating artery infraction, and positive associations of atrial fibrillation and serum total cholesterol with cortical artery infraction were found.

尽管中风的死亡率和发病率在日本有所下降，但中风是导致身体和金属残疾的主要原因。由于计算机断层扫描（CT扫描）的广泛使用，尽管脑出血的发病率随着高血压的控制和生活方式的改善而下降，但仍有可能发现小出血的中风。根据临床报告，皮质动脉区脑梗塞的数量正在增加，其中大多数是血栓性梗塞。然而，我国很少有社区研究来明确脑卒中类型及其危险因素的患病率。最近 CT 扫描的广泛使用使我们能够进行基于社区的研究。调查社区为日本东北部的两个农村人口和日本中部的一个农村人口。 1990 年的人口普查人口分别为 3,000、7,000 和 17,000。三个社区203名40岁及以上男女脑卒中病例中，142人接受了CT扫描。对于142例脑卒中病例，按照性别和年龄对脑卒中类型的患病率进行了统计。日本脑出血和穿通动脉梗塞的患病率高于美国和欧洲国家。在皮质动脉梗塞的患病率中观察到相反的趋势。为了检查中风类型的危险因素，进行了一项巢式病例对照研究。除了之前的流行病学研究结果外，还发现高血压与穿通动脉梗塞之间存在正相关，心房颤动和血清总胆固醇与皮质动脉梗塞之间存在正相关。