Large prospective cohort study for the pro-oxidant and antioxidant factors and atherosclerotic disease.

针对促氧化剂和抗氧化剂因子与动脉粥样硬化疾病的大型前瞻性队列研究。

• 批准号: 19390174
• 负责人: ISO Hiroyasu
• 金额: $ 11.32万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390174/
• 关键词: 動脈硬化; 酸化; 生活習慣; リスク; コホート研究; 高血圧; 脳卒中; 遺伝子多型

To examine potential effects of the pro-oxidant and antioxidant factors on the atherosclerotic disease, we conducted prospective studies for the incidence of and mortality from stroke and coronary heart disease using stored blood samples among 70,000 Japanese men and women aged 40-79. Also, we built a nutritional database and examined the association of antioxidant foods and nutritions with atherosclerotic disease incidence and mortality. We identified pro-oxidant factors (high level of hs-CRP and C. pneumoniae antibody titers of IgA) and antioxidant factors (fish, n-3 unsaturated fatty acids and vitamins A, B, C and E intakes) on atherosclerotic disease incidence and mortality.

为了检验促氧化剂和抗氧化因子对动脉粥样硬化疾病的潜在影响，我们对70,000名年龄在40-79岁的日本男性和女性进行了前瞻性研究，研究对象是中风和冠心病的发病率和死亡率。此外，我们建立了一个营养数据库，并检查了抗氧化食物和营养素与动脉粥样硬化性疾病发病率和死亡率的关系。我们确定了促氧化因素(高水平的hs-CRP和肺炎衣原体抗体滴度的IgA)和抗氧化因素(鱼类、n-3不饱和脂肪酸和维生素A、B、C和E的摄入量)对动脉粥样硬化性疾病的发病率和死亡率。

项目成果

高感度CRPとの脳卒中発症との関連:地域住民におけるNested-casecontrolstudy

高敏CRP与脑卒中发病的关联：当地居民的巢式病例对照研究

• 发表时间: 2009
• 作者: Fukushima W;Hayashi Y;Mizuno Y;Suzuki K;Kase T;Ohfuji S;Fujieda M;Maeda A;Hirota Y;チェイチョイライ
• 通讯作者: チェイチョイライ

Chlamydia pneumoniae infection was associated with risk of mortality from coronary heart disease in Japanese women but not men : the JACC Study

肺炎衣原体感染与日本女性冠心病死亡风险相关，但与男性无关：JACC 研究

• 发表时间: 2010
• 期刊: J Atheroscl Thromb (In press)
• 作者: Sakurai N;et al.
• 通讯作者: et al.

Interrelationship between serum vitamin C and hs-CRP levels in middle-aged Japanese men and women.

日本中年男性和女性血清维生素 C 和 hs-CRP 水平之间的相互关系。

• 发表时间: 2009
• 作者: Kubota Y;Moriyama Y;Yamagishi Y;et. al.
• 通讯作者: et. al.

Fish, omega-3 polyunsaturated fatty acids, and mortality from cardiovas-cular diseases in a nationwide community-based cohort study of Japanese men and women.

一项针对日本男性和女性的全国性社区队列研究中的鱼、omega-3 多不饱和脂肪酸和心血管疾病死亡率。

• 发表时间: 2008
• 期刊: J Am Coll Cardiol 52
• 作者: Yamagishi K;Iso H;et al.
• 通讯作者: et al.

Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD:: The japan public health center-based prospective study cohort I

• DOI: 10.1080/07315724.2008.10719684
• 发表时间: 2008-02-01
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
• 影响因子: 3.5
• 作者: Ishihara, Junko;Iso, Hiroyasu;Tsugane, Shoichiro
• 通讯作者: Tsugane, Shoichiro