Epidemiologic study on environmental and genetic factors for development of hypertension, A long-term follow-up study for two generations

高血压发生的环境和遗传因素的流行病学研究，两代人的长期随访研究

• 批准号: 04670324
• 负责人: ISO Hiroyasu
• 金额: $ 1.34万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670324/
• 关键词: Hypertension; Environmental factor; Genetic factor; Follow-up study

Factors related with development of hypertension were examined by 1) a 6 to 8 year follow-up of normotensive persons, and 2) comparison of blood pressure and related factors between parents and offsprings.1. A follow-up of normotensive personsFactors related with the development of hypertension among normotensive persons were examined by univariate and multivariate analyzes. Hypertension was defined as systolic blood pressure>=160mmHg, diastolic blood pressure >=95mmHg, and/or taking antihypertensive medication.In men, no relation was found between body mass index and blood pressure in the 1960s cohort, but significant relation appeared in the later cohorts. A substantial decline in manual work due to mechanization of farming may contributed to changes in the relation between body mass index and the development of hypertension.Echocardiograpically-determined left ventricular mass (LVM) was significantly associated with an increase in blood pressure levels. The relation between LVM and … More blood pressure changes was stronger in urban men than in rural men. The weaker association between LVM and blood pressure increase in rural compared with urban men was probably the result of effects of higher physical activity, leading to a larger left ventricular internal dimension. An increased LVM predicts subsequent blood pressure increase in normotensive men in the presence of a normal or small internal dimension.2. Blood pressure comparison between parents and offsrpings in a Akita rural populationMale offsprings showed a 10 mmHg lover mean systolic blood pressure than male parents, and female offsprings showed a 3 mmHg lower mean systolic blood pressure than female parents. Lower blood pressure levels in offsprings were attributable to lifestyle changes between 1960s and 1980s. A lack of significant association in blood pressure levels between male offsprings and parents may be due to larger effects of environmental factors then genetic factors in development of hypertension in this population. Less

通过对血压正常者6 ~ 8年的随访，以及父母与子女血压及相关因素的比较，探讨高血压发生的相关因素.对血压正常者的随访结果进行单因素和多因素分析。高血压定义为收缩压≥ 160 mmHg，舒张压≥ 95 mmHg，和/或服用降压药。在男性中，体重指数与血压在60年代队列中未发现相关性，但在以后队列中出现显著相关性。由于农业机械化，体力劳动的大量减少可能导致体重指数与高血压发展之间关系的变化，超声心动图测定的左心室质量（LVM）与血压水平的升高显著相关。LVM与 ...更多信息 城市男性的血压变化比农村男性大。与城市男性相比，农村男性的左心室质量与血压升高之间的关联较弱，这可能是由于较高的体力活动影响，导致左心室内径较大。在血压正常的男性中，如果存在正常或较小的内部尺寸，则左心室质量增加预示着随后的血压升高。秋田农村人群父母与子女的血压比较男性子女的平均收缩压比男性父母低10 mmHg，女性子女的平均收缩压比女性父母低3 mmHg。后代血压水平较低是由于20世纪60年代至80年代生活方式的改变。男性后代和父母之间的血压水平缺乏显着的关联可能是由于环境因素的影响更大，而不是遗传因素在这一人群中的高血压的发展。少

项目成果

嶋本喬、磯博康 他: "軽症高血圧の疫学" 日本臨床 増刊 高血圧(下). 639. 287-295 (1992)

Takashi Shimamoto、Hiroyasu Iso 等：“轻度高血压的流行病学”日本临床特别版高血压（第 2 部分）。 639. 287-295 (1992)。

Iso H,et al.: "Left ventricular mass and subsequent blood pussure changes among middle-aged men in rural and urban Japanese population" Circulation. 89. 1717-1724 (1994)

Iso H 等人：“日本农村和城市中年男性的左心室质量和随后的血压变化”循环。

嶋本喬、磯博康: "日本人の血圧" 医学のあゆみ. 169. 527-532 (1994)

Takashi Shimamoto、Hiroyasu Iso：“日本人的血压”医学史 169. 527-532 (1994)。

Iso H,et al.: "Left ventricular mass and subsequent blood pussuve changes among middle-aged men in rural and urban Japanese population." Circulation. 89. 1717-1724 (1994)

Iso H 等人：“日本农村和城市中年男性的左心室质量和随后的血脓性变化。”

Hiroyasu Iso,et al: "Left Venlricular Mass and Subsequent Blood Pressure changes Among Middle-Aged Men in Rural and Urban Japanese Populations" Circulation. (in press). (1994)

Hiroyasu Iso 等人：“日本农村和城市人口中中年男性的左心室质量和随后的血压变化”循环。