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Orthodontic examination on correspondence between change in occlusion and periodontal mechanoreceptors-by means of biomechanical, physiological, and immunohistological approaches-

通过生物力学、生理学和免疫组织学方法，对咬合变化和牙周机械感受器之间的对应关系进行正畸检查

基本信息

批准号：
09307049
负责人：
SOMA Kunimichi
金额：
$ 23.87万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

The purpose of this research is to clarify the dynamic change of periodontal mechanoreceptors before and after orthodontic treatment by means of biomechanical, physiological and immunohistological approaches.1. Biomechanical approachWe improved occlusal force sensor (the core of the sensor was a pressure sensitive rubber) which was designed to measure the momentarily changing occlusal force of the whole dentition. That is to say, we devised this sensor of small size to measure tooth one by one. And we measured the occlusal force onto each tooth when functioning.The minute displacement of the maxillary central incisor was measured three dimensionally indirectly with optic fiber sensor. According to different spots where external force Was applied, the pattern of displacement varied, and the phenomenon that center of rotation of the tooth changed could be observed. Also, we measured the displacement of the maxillary first molar when clenching with direct-contact minute displacement devic … More e. It indicated that different contact pattern between the upper and lower first molars resulted in varied tooth displacement pattern.2. Physiological approachThe main innervation nerves of periodontal mechanoreceptors of rats are A delta fibers. In contrast with incisors, of mixed fast-adapted and slowly-adapted types, only fast-adapted types can be found in molars. Moreover, as for the change in adaptive characteristics of periodontal mechanoreceptors of rats after antagonists were extracted, change of threshold in response to mechanical stimulation could be seen, and the change of proportion of reaction patterns could also be observed. Furthermore, in mice, the nerve transmission substances necessary for mastication changed with growth.3. Immunohistological approach2,4,6 and 8 weeks after we set a device onto the lower incisors of mice of 3 weeks old after birth to induce anterior crossbite, and another 2,4,6 and & weeks after the device used for inducing anterior crossbite was removed, we utilized immunohistological method to observe the distribution and morphological change of Ruffini nerve endings by PGP- 9.5. As with anterior crossbite was induced, the Ruffini nerve endings located at the palatal sides of the periodontal membranes of the anterior maxillary incisors degenerated and lessened. However, in the case that anterior crossbite ameliorated after the appliance was removed, Ruffini nerve endings regenerated. Thereby, we confirmed the correspondence between change of occlusion and periodontal mechanoreceptors. Less

本研究的目的是通过生物力学、生理学和免疫组织学等方法阐明正畸治疗前后牙周机械感受器的动态变化。 1．生物力学方法我们改进了咬合力传感器（传感器的核心是压敏橡胶），旨在测量整个牙列瞬间变化的咬合力。也就是说，我们设计了这个小尺寸的传感器来一颗一颗地测量牙齿。并测量了每颗牙齿工作时的咬合力。利用光纤传感器间接三维测量上颌中切牙的微小位移。根据施加外力的位置不同，位移的模式也不同，并且可以观察到齿的旋转中心发生变化的现象。此外，我们还测量了用直接接触式微小位移装置咬紧时上颌第一磨牙的位移……更多e。表明上、下第一磨牙接触方式不同，导致牙齿移位方式不同。 2．生理途径大鼠牙周机械感受器的主要支配神经是Aδ纤维。与门牙相反，磨牙是快适应型和慢适应型的混合体，只有快适应型。此外，提取拮抗剂后大鼠牙周机械感受器适应性特征的变化，可以看到对机械刺激反应的阈值的变化，也可以观察到反应模式比例的变化。此外，在小鼠中，咀嚼所需的神经传递物质随着生长而变化。 3．免疫组织学方法在生后3周龄小鼠的下切牙上设置装置诱导前牙反牙合后2、4、6和8周，并在取出用于诱导前牙反牙合的装置后2、4、6和8周，采用免疫组织学方法通过PGP-9.5观察Ruffini神经末梢的分布和形态变化。随着前牙反牙合的诱发，位于上颌前切牙牙周膜腭侧的鲁菲尼神经末梢退化并减少。然而，在移除矫治器后前牙反咬合得到改善的情况下，鲁菲尼神经末梢再生了。由此，我们证实了咬合变化与牙周机械感受器之间的对应关系。较少的