Elucidation of functional significance of caveola in periodontal mechanoreceptor

阐明牙周机械感受器小凹的功能意义

• 批准号: 20390464
• 负责人: MAEDA Takeyasu
• 金额: $ 12.15万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390464/
• 关键词: カベオラ; カベオリン; 機械受容; 歯根膜ルフィニ神経終末; カルシウムイオン; 歯根膜; ルフィニ神経終末; 末梢神経再生; 軸索-シュワン細胞相互作用; 終末シュワン細胞; GDNF; 機械受容器

The Ruffini endings, a primary mechanoreceptor in the periodontal ligament, well-develop caveolae in their cell membrane. The present study examined the functional significance of caveolae in the periodontal Ruffini endings. The caveolae were consisted of caveolin-1 with diverse functions. A unique immuno-localization pattern of caveolin-1 and Ca^<2+>-pump suggested caveolae is involved in the quick elimination of intracellular Ca^<2+> which influx into the axon terminals in mechanotransduction.

Ruffini终末是牙周膜中的主要机械感受器，其细胞膜上的小窝发育良好。本研究探讨牙周Ruffini终末小窝的功能意义。小窝由功能多样的小窝蛋白1组成。Caveolin-1和Ca^<2+>-泵的独特免疫定位模式表明，Caveolin参与了细胞内Ca^<2+>的快速清除，这些Ca^<2+>在机械传导中流入轴突终末。

项目成果

Immunolocalization of caveolin-1 and Ca^<2+>-ATPase in the periodontal Ruffini endings.

牙周Ruffini末端中caveolin-1和Ca^2-ATP酶的免疫定位。

• 发表时间: 2008
• 作者: A. Suzuki;et al.
• 通讯作者: et al.

Detection of acid-sensing ion channel 3 (ASIC3) in periodontal Ruffini endings of mouse incisors

• DOI: 10.1016/j.neulet.2010.11.023
• 发表时间: 2011-01-20
• 期刊: NEUROSCIENCE LETTERS
• 影响因子: 2.5
• 作者: Rahman, Farhana;Harada, Fumiko;Maeda, Takeyasu
• 通讯作者: Maeda, Takeyasu

Dental innervation

牙齿神经支配

• 发表时间: 2010
• 作者: Obitsu S;Hironori NA;Hasegawa A;Nakahama K;Morita I;Nishigaki N;Hayashi;Masuda T;Kannagi M.;T.Maeda
• 通讯作者: T.Maeda

Behavioral and histological observations of sensory impairment caused by tight ligation of the trigeminal nerve in mice.

紧密结扎三叉神经引起小鼠感觉障碍的行为和组织学观察。

• 发表时间: 2009
• 期刊: J.Neuroscience Methods
• 作者: Seino;Maeda;et al.
• 通讯作者: et al.

口腔解剖学

口腔解剖学

• 发表时间: 2009
• 作者: Tsuchiya T;Nakahama K;Asakawa Y;Maemura T;Tanaka M;Takeda S;Morita M;Morita I;前田健康
• 通讯作者: 前田健康