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PATHOLOGICAL STUDY ON THE ENZOOTIC CARDIOMYOPATHY OF DEER

鹿地方性心肌病的病理学研究

基本信息

批准号：
09045074
负责人：
YOSHIKAWA Takashi
金额：
$ 2.3万
依托单位：
Kitasato University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

1. Myocardial lesions from enzootic cardiomyopathy in Sika deer: On a stock farm in the northeastern district of China, histopathological and electronmicroscopic examinations were made of 40 Sika deer (Cervus nippon Temminck) aged from 1 day to 2 years and suffering cardiac arrest. Ultrastructural examination revealed mitochondrial deformation and calcium deposition. These phenomena resemble those observed in cases of cardiomyopathy caused in other animals by selenium-vitamin E deficiency.2. Hepatic ceroid-lipofuscinosis in enzootic cardiomyopathy of Sika deer: Hepatic lesions in 25 Sika deer (Cervus nippon Temminck) aged 1-15 days, affected by selenium deficient cardiomyopathy, were examined histopathologically. Characteristic pathological findings, induced by stagnation of the plasma proteins of the cytoplasm, consisted of vacuolar degeneration of hepatocytes, formation of hyalin droplets, and ceroid-lipofuscinosis. Electron microscopically, these changes were closely associated with … More degeneration of the endoplasmic reticulum and mitochondria. Peroxisomes, which were observed around the vacuoles, were regarded as a reactive result of membrane disturbance caused by a decrease in glutathione peroxidase (GSH-Px).3. Pulmonary mycosis associated with selenium-deficient cardiomyopathy in Sika deer: Pulmonary mycosis four domestic Sika deer aged 1 to 2 weeks suffering from selenium deficiency (enzootic cardiomyopathy) were examined histopathologically, histochemically and by electron microscopy. From the morphological features of mycosis there were diagnosed aspergillosis in three cases and mucormycosis in one case. The pathologic reaction within lesions of aspergillus was dominated by granulomatous type with neutrophils, macrophages and giant cells, and mucor lesions were remarkable vasculitis with fungal thrombi. It is suggested that the atrophy of lymph follicles and decrease number of T lymphocytes in lympatic organs is closely correlated with selenium deficiency and immunological disorders. Less

1.西卡鹿心肌病的研究：在东北地区的一个畜牧场，对40只1日龄至2岁的西卡鹿（Cervus nippon Temminck）心脏骤停后的心肌组织病理学和电镜进行了观察。超微结构检查显示线粒体变形和钙沉积。这些现象类似于在其他动物中由硒-维生素E缺乏引起的心肌病病例中观察到的现象。西卡鹿地方性心肌病中的肝脏蜡样脂褐质沉积症：对25只1-15日龄患有缺硒心肌病的西卡鹿（Cervus nippon Temminck）的肝脏病变进行了组织病理学检查。由细胞质的血浆蛋白停滞诱导的特征性病理学发现包括肝细胞空泡变性、透明质液滴形成和蜡样脂褐质沉积症。电子显微镜下，这些变化与 ...更多信息内质网和线粒体变性。过氧化物酶体出现在液泡周围，被认为是谷胱甘肽过氧化物酶（GSH-Px）减少引起的细胞膜紊乱的反应结果.西卡鹿肺真菌病与缺硒性心肌病的相关性：对4只1 ~ 2周龄的缺硒性（地方性心肌病）家养西卡鹿进行了肺真菌病的组织病理学、组织化学和电镜观察。从真菌病的形态学特征诊断为曲霉菌病3例，毛霉菌病1例。曲霉菌病皮损内的病理反应以肉芽肿型为主，有中性粒细胞、巨噬细胞和巨细胞浸润，毛霉病皮损内血管炎明显，并有真菌血栓形成。提示硒缺乏与机体免疫功能紊乱密切相关。少