权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Pathology of the Enzootic ataxia in Farmed Deer

养殖鹿地方性共济失调的病理学

基本信息

批准号：
04045047
负责人：
YOSHIKAWA Takashi
金额：
$ 3.39万
依托单位：
KITASATO University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

项目摘要

Enzootic spinal ataxia in deer has been described by workers in many parts of the world, but there have been no previous reports of this disease occurring in China.This report deal with histopathology of enzootic spinal ataxia in sika deer (Cervus nippon Temminck), encountered at stock farm in the Northeastern District of China.Clinical findings : Enzootic spinal ataxia occurred about 10% of all Sika deer on one stock farm where 1,500-2,000 deer were farmed. Affected deer showed progressive lumber weakness, posterior wobbling, and/or unsteady gait. These condition developed progressively and chronically. In severe cases, growth was retarded, and depigmentation of and alopecia of ordinary hair, especially around eyes were also observed. In some cases deformity of the extremities and bone fracture were observed.Histological findings : Thirteen sika deer aged from 4 to 9 years were examined. The principal pathologic changes were (1) spongy vacuolation and myelin deficiency in white matter of the spinal cord and brain stem, (2) fibrosis and rupture of elastic fibers of the spinal arterioles, and (3) mesothelial hyperplasia in the spinal aracroid.Serum copper values were significantly lower than those of normal Sika deer.Pathogenesis of the demyelinating change in spinal white matter are discussed in relation to the arterial lesions. The possible role of copper deficiency in the etiology of the condition is discussed.

世界许多地方的工作人员都描述了鹿的地方性脊髓共济失调，但以前没有关于这种疾病在中国发生的报道。本报告涉及中国东北地区畜牧场发现的梅花鹿地方性脊髓共济失调的组织病理学。临床发现：地方性脊髓共济失调约占所有梅花鹿的 10% 一个养殖场饲养了 1,500-2,000 只鹿。受影响的鹿表现出进行性腰部无力、后部摆动和/或步态不稳定。这些病症是逐渐且长期发展的。在严重的情况下，生长迟缓，并且还观察到普通头发尤其是眼睛周围的色素脱失和脱发。在某些情况下，观察到四肢畸形和骨折。组织学检查结果：检查了13只4至9岁的梅花鹿。主要病理变化为（1）脊髓和脑干白质海绵状空泡化和髓磷脂缺乏，（2）脊髓小动脉纤维化和弹力纤维断裂，（3）脊髓蛛网膜间皮增生。血清铜值明显低于正常梅花鹿。脊髓白质脱髓鞘改变的发病机制讨论与动脉病变有关的问题。讨论了铜缺乏在该病病因中的可能作用。