Study on Biofunctional Restorative Material with Pulpal Cell

牙髓细胞生物功能修复材料的研究

• 批准号: 09045078
• 负责人: IWAKU Masaaki
• 金额: $ 3.78万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09045078/
• 关键词: biofunctional materials; adhesive restorative materials; pulpal cells; affinity; physiological activity

This project undertaken to perform 「Study on Biofunctional Restorative Material with Pulpal cell」, was funded in part by a 3-year grant in aid from the Monbusho (Ministry of Education) International Scientific Research Program -University- to University Cooperative Research, as a joint effort between the Department of Restorative Dentistry, University of California, San Francisco, School of Dentistry and the Department of Operative Dentistry and Endodontics, Niigata University Faculty of Dentistry.This study consists of the following three parts.1) Research concerning with the human dentin : the ultra-microstructure of the human sound and carious dentin, dentin demineralization, the dentin substrate, and human dentin and the dentin resin adhesive interface.2) Research concerning with the dental pulp : the cell-biological and immunohistochemical studies on the pulpal function of normal teeth, and the reaction of dental pulp to the various external irritations.3) Research concerning with the dental materials : fluoride release from the various adhesive dental materials, fluoride uptake by human enamel and dentin from materials, and its effect to acid resistance.

本项目以“牙髓细胞生物功能修复材料的研究”为主题，部分由教育部国际科学研究计划-大学-大学合作研究资助，由加州大学旧金山分校牙科学院修复牙科系和牙髓外科与牙髓学系共同努力。新泻大学牙科学院。本研究由以下三个部分组成。1)关于人牙本质的研究：人牙本质与龋齿的超微结构、牙本质脱矿、牙本质基质、人牙本质与牙本质树脂粘接剂界面。2)牙髓研究：正常牙齿牙髓功能的细胞生物学和免疫组织化学研究，以及牙髓对各种外界刺激的反应。3)牙材料研究：各种牙材料黏合剂中氟化物的释放、人牙釉质和牙本质对氟化物的吸收及其对耐酸性能的影响。

项目成果

G. W. Marshall, Jr.: "Dentin demineralization : Effect of dentin depth, pH and different acids"Den Mater. 13. 338-343 (1997)

G. W. Marshall, Jr.：“牙本质脱矿：牙本质深度、pH 值和不同酸的影响”Den Mater。

G. W. Marshall, Jr., N. Inai, I. W. Magidi, M. Balooch, J. H. Kinney, J. Tagami, and S. J. Marshall: "Dentin demineralization : Effect of dentin depth, pH and different acids."Den Mater. 13. 338-343 (1997)

G. W. Marshall, Jr.、N. Inai、I. W. Magidi、M. Balooch、J. H. Kinney、J. Tagami 和 S. J. Marshall：“牙本质脱矿质：牙本质深度、pH 值和不同酸的影响。”Den Mater。

Nagako Yoshiba et al: "Expression and localization of laminin-5 subunits in the mouse incisor" Cell and Tissue Research. 292巻. 143-149 (1998)

Nagako Yoshiba 等人：“小鼠门牙中层粘连蛋白 5 亚基的表达和定位”细胞和组织研究 292. 143-149 (1998)。

S. J. Marshall: "Human dentin and the dentin-resin adhesive interface"46. 2529-2539 (1998)

S. J. Marshall：“人类牙本质和牙本质-树脂粘合界面”46。

G. W. Marshall, Jr.: "Effect of citric acid concentration on dentin demineralization, dehydration, and dehydration : Atomic force microscopy study"J. Biomed Mater Res. 42. 500-507 (1998)

G. W. Marshall, Jr.：“柠檬酸浓度对牙本质脱矿、脱水和脱水的影响：原子力显微镜研究”J.