Joint Study on the Development of Novel Joint Prostheses

新型关节假体开发联合研究

• 批准号: 10044165
• 负责人: MURAKAMI Teruo
• 金额: $ 2.5万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10044165/
• 关键词: Artificial Joint; Elastohydrodynamic Lubrication; Wear; Synovial Fluid; Artificial Joint Materials; Artificial Cartilage; Joint Simulator; Biotribology; バイオトラポロジー

The object of this research is to conduct the joint research between Kyushu University, The University of Leeds and University of Bradford to elucidate the lubrication and wear mechanism in artificial joints and develop novel joint prostheses. Members of this joint research visited Japan or United Kingdom for mutual discussion. Furthermore, during their visiting the presentations of papers on this research project were carried out at the international conferences, I.e., at the Third World Congress of Biomechanics, 25th Leeds-Lyon Symposium on Tribology, 1st Asia Int. Conf. on Tribology, Asiatrib'98, 26th Leeds-Lyon Symposium on Tribology and 12th International Symposium on Ceramics in Medicine. At the International Symposium on Lubrication Mechanism in Natural and Artificial Joints, which was organized by Prof. Murakami and Prof. Fisher at the 25th Meeting of Japanese Society of Clinical Biomechanics and Related Research, Dr. Jin and Dr. Sawae presented their papers as symposists.In th … More is joint study, the following results were shown. The fundamental mechanism in adaptive multimode lubrication in natural synovial joints was discussed by focusing the lubricating ability of cartilage surface layer. The geometric feature of knee joint was indicated by 3D Computer Graphics technique. On the lubrication mechanism in artificial joints, the fluid film formation, friction or wear in knee prosthesis models with compliant artificial cartilage such as polyurethane, silicone rubber, polyvinylalcohol (PVA) hydrogel and semi-interpenetrating polymer network (SIPN) hydrogel were evaluated by simulator or sliding tests. Atomic Force Microscopy (AFM) observation was effective in evaluation of changes in surface layer of natural articulator cartilage and artificial cartilage. The superiority in fluid film formation during walking for transverse elliptical conjunction to longitudinal one with the same contact area in knee prostheses was shown in numerical analysis. The friction and wear in existing artificial joints composed of metal or ceramics and ultra-high molecular weight polyethylene (UHMWPE), ceramics-on-ceramics, metal-on-metal were evaluated by unidirectional and multidirectional sliding tests and simulators. The influence of multi-directional motion, constituents of lubricants, material properties and geometrical design with surface roughness on wear behavior were summarized. The properties of wear particles and their biological reaction were investigated. The friction control of elastomeric material by applied electric field and wear reduction of metal-on-metal pair by magnetic field were demonstrated. Less

本研究的目的是九州大学、利兹大学和布拉德福德大学进行联合研究，以阐明人工关节的润滑和磨损机制，并开发新型关节假体。此次联合研究的成员访问了日本或英国进行相互研讨。此外，在他们访问期间，有关该研究项目的论文在国际会议上进行了介绍，即第三届世界生物力学大会、第25届利兹-里昂摩擦学研讨会、第一届亚洲国际摩擦学研讨会。会议。摩擦学，Asiatrib'98，第 26 届利兹-里昂摩擦学研讨会和第 12 届国际医学陶瓷研讨会。在日本临床生物力学及相关研究学会第 25 届会议上，由 Murakami 教授和 Fisher 教授组织的自然关节和人工关节润滑机制国际研讨会上，Jin 博士和 Sawae 博士作为专题讨论者发表了他们的论文。在这项联合研究中，显示了以下结果。从软骨表层的润滑能力出发，探讨了自然滑膜关节自适应多模式润滑的基本机制。通过3D计算机图形技术显示膝关节的几何特征。在人工关节的润滑机制方面，通过模拟器或滑动试验评估了聚氨酯、硅橡胶、聚乙烯醇（PVA）水凝胶和半互穿聚合物网络（SIPN）水凝胶等顺应性人工软骨膝关节假体模型的液膜形成、摩擦或磨损。原子力显微镜（AFM）观察可有效评估天然咬合软骨和人工软骨表面层的变化。数值分析表明，在膝关节假体接触面积相同的情况下，横向椭圆连接在步行过程中液膜形成优于纵向椭圆连接。通过单向和多向滑动试验和模拟器评估现有由金属或陶瓷和超高分子量聚乙烯（UHMWPE）、陶瓷对陶瓷、金属对金属组成的人工关节的摩擦和磨损。总结了多向运动、润滑剂成分、材料性能和表面粗糙度的几何设计对磨损行为的影响。研究了磨损颗粒的性质及其生物反应。演示了通过施加电场控制弹性体材料的摩擦以及通过磁场减少金属对金属对的磨损。较少的

项目成果

T.Murakami: "Role of Surface Layers of Natural and Artificial Cartilage in Thin Film Lubrication"Lubrication at Frontier, Elsevier. 737-747 (1999)

T.Murakami：“天然和人造软骨表面层在薄膜润滑中的作用”前沿润滑，Elsevier。

Z. M. Jin: "Reducing Asperity Contact in UHMWPE Knee Joint Replacements through Improving Lubrication Mechanisms"Trans. International Conference on Knee Replacement 1974-2024. 2-24. 66-69 (1999)

金子明：“通过改进润滑机制减少 UHMWPE 膝关节置换术中的粗糙接触”，Trans。

Y.Nakanishi: "Improvement of Wear Characteristic of Metal-on-Metel Artificial Hip Joint by means of Magnetic Field"JSME International Journal.. Vol.42 No3. 552-559 (1999)

Y.Nakanishi：“通过磁场改善金属对金属人工髋关节的磨损特性”JSME 国际期刊.. Vol.42 No3。

T. Murakami: "Role of Surface Layers of Natural and Artifical Cartilage in Thin Film Lubrication"Lubrication at Frontier, Elsevier. 737-747 (1999)

T. Murakami：“天然和人造软骨表面层在薄膜润滑中的作用”前沿润滑，爱思唯尔。

Y. Sawae: "Improvement in Microstructure and Wear Property of Alumina Ceramics for Joint Prostheses"Bioceramics. Vol. 12. 99-103 (1999)

Y. Sawae：“关节假体用氧化铝陶瓷的微观结构和磨损性能的改善”生物陶瓷。