Joint Study on the Development of Novel Joint Prostheses

新型关节假体开发联合研究

• 批准号: 10044165
• 负责人: MURAKAMI Teruo
• 金额: $ 2.5万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10044165/
• 关键词: Artificial Joint; Elastohydrodynamic Lubrication; Wear; Synovial Fluid; Artificial Joint Materials; Artificial Cartilage; Joint Simulator; Biotribology; バイオトラポロジー

The object of this research is to conduct the joint research between Kyushu University, The University of Leeds and University of Bradford to elucidate the lubrication and wear mechanism in artificial joints and develop novel joint prostheses. Members of this joint research visited Japan or United Kingdom for mutual discussion. Furthermore, during their visiting the presentations of papers on this research project were carried out at the international conferences, I.e., at the Third World Congress of Biomechanics, 25th Leeds-Lyon Symposium on Tribology, 1st Asia Int. Conf. on Tribology, Asiatrib'98, 26th Leeds-Lyon Symposium on Tribology and 12th International Symposium on Ceramics in Medicine. At the International Symposium on Lubrication Mechanism in Natural and Artificial Joints, which was organized by Prof. Murakami and Prof. Fisher at the 25th Meeting of Japanese Society of Clinical Biomechanics and Related Research, Dr. Jin and Dr. Sawae presented their papers as symposists.In th … More is joint study, the following results were shown. The fundamental mechanism in adaptive multimode lubrication in natural synovial joints was discussed by focusing the lubricating ability of cartilage surface layer. The geometric feature of knee joint was indicated by 3D Computer Graphics technique. On the lubrication mechanism in artificial joints, the fluid film formation, friction or wear in knee prosthesis models with compliant artificial cartilage such as polyurethane, silicone rubber, polyvinylalcohol (PVA) hydrogel and semi-interpenetrating polymer network (SIPN) hydrogel were evaluated by simulator or sliding tests. Atomic Force Microscopy (AFM) observation was effective in evaluation of changes in surface layer of natural articulator cartilage and artificial cartilage. The superiority in fluid film formation during walking for transverse elliptical conjunction to longitudinal one with the same contact area in knee prostheses was shown in numerical analysis. The friction and wear in existing artificial joints composed of metal or ceramics and ultra-high molecular weight polyethylene (UHMWPE), ceramics-on-ceramics, metal-on-metal were evaluated by unidirectional and multidirectional sliding tests and simulators. The influence of multi-directional motion, constituents of lubricants, material properties and geometrical design with surface roughness on wear behavior were summarized. The properties of wear particles and their biological reaction were investigated. The friction control of elastomeric material by applied electric field and wear reduction of metal-on-metal pair by magnetic field were demonstrated. Less

本研究的目的是开展九州大学、利兹大学和布拉德福德大学的联合研究，以阐明人工关节的润滑和磨损机制，并开发新型关节假体。这项联合研究的成员访问了日本或英国，进行了相互讨论。此外，在访问期间，在国际会议上发表了关于这一研究项目的论文，即在第三届世界生物力学大会、第25届利兹-里昂摩擦学研讨会、第一届亚洲国际会议上发表了论文。电话会议1998年亚洲摩擦学研讨会、第26届利兹-里昂摩擦学研讨会和第12届国际陶瓷医学研讨会。在由村上教授和费舍尔教授在日本临床生物力学及相关研究学会第25届会议上组织的关于天然和人工关节的润滑机理的国际研讨会上，金博士和萨瓦博士以研讨会的形式提交了他们的论文。在The…更多的是联合研究，主要研究结果如下。从软骨表层的润滑能力出发，探讨了自然滑膜关节自适应多模式润滑的基本机制。用三维计算机图形学技术显示膝关节的几何特征。在人工关节的润滑机制方面，通过模拟实验和滑动实验，评价了聚亚安酯、硅橡胶、聚乙烯醇(PVA)水凝胶和半互穿聚合物网络(SIPN)水凝胶等柔顺性人工软骨假体模型中流体膜的形成、摩擦和磨损。原子力显微镜(AFM)观察是评价天然关节软骨和人工软骨表层变化的有效方法。数值分析表明，在膝关节假体中，横向椭圆形接合与相同接触面积的纵向接合在行走过程中形成液膜的优越性。通过单向和多向滑动试验和模拟试验，对现有的金属或陶瓷与超高相对分子质量聚乙烯(UHMWPE)、陶瓷对陶瓷、金属对金属人工关节的摩擦磨损性能进行了评价。总结了多向运动、润滑剂组成、材料性能和几何设计与表面粗糙度对磨损行为的影响。研究了磨粒的性质及其生物反应。论证了外加电场对弹性体材料的摩擦控制和外加磁场对金属对金属副的减磨作用。较少

项目成果

T.Murakami: "Role of Surface Layers of Natural and Artificial Cartilage in Thin Film Lubrication"Lubrication at Frontier, Elsevier. 737-747 (1999)

T.Murakami：“天然和人造软骨表面层在薄膜润滑中的作用”前沿润滑，Elsevier。

Z. M. Jin: "Reducing Asperity Contact in UHMWPE Knee Joint Replacements through Improving Lubrication Mechanisms"Trans. International Conference on Knee Replacement 1974-2024. 2-24. 66-69 (1999)

金子明：“通过改进润滑机制减少 UHMWPE 膝关节置换术中的粗糙接触”，Trans。

Y.Nakanishi: "Improvement of Wear Characteristic of Metal-on-Metel Artificial Hip Joint by means of Magnetic Field"JSME International Journal.. Vol.42 No3. 552-559 (1999)

Y.Nakanishi：“通过磁场改善金属对金属人工髋关节的磨损特性”JSME 国际期刊.. Vol.42 No3。

T. Murakami: "Role of Surface Layers of Natural and Artifical Cartilage in Thin Film Lubrication"Lubrication at Frontier, Elsevier. 737-747 (1999)

T. Murakami：“天然和人造软骨表面层在薄膜润滑中的作用”前沿润滑，爱思唯尔。

Y. Sawae: "Improvement in Microstructure and Wear Property of Alumina Ceramics for Joint Prostheses"Bioceramics. Vol. 12. 99-103 (1999)

Y. Sawae：“关节假体用氧化铝陶瓷的微观结构和磨损性能的改善”生物陶瓷。