Human hippocampus subregions organisation and associative memory processes

人类海马分区组织和联想记忆过程

• 批准号: DP210102378
• 负责人: Prof Olivier Piguet
• 金额: $ 26.9万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102378
• 关键词: Human; hippocampus; subregions; organisation; associative

This proposal will investigate the hippocampus, a highly inter-connected structure containing many subregions. Although considered the memory centre of the brain, we still do not know the exact roles of these subregions during memory processes. Using novel brain neuroimaging acquisition methods and analyses, this project aims to map the internal structure and functions of the hippocampus and its functional networks under different memory conditions and how these functions change with age. The intended outcome of this proposal is to provide the foundations for the first integrated model of human memory and its biological basis and to generate a benchmark against which future development of memory interventions and retraining can be measured.

这项计划将研究海马体，一个高度相互连接的结构，包含许多子区域。虽然被认为是大脑的记忆中心，但我们仍然不知道这些子区域在记忆过程中的确切作用。该项目利用新的脑神经成像采集方法和分析，旨在绘制不同记忆条件下海马及其功能网络的内部结构和功能，以及这些功能如何随年龄变化。这一建议的预期成果是为人类记忆的第一个综合模型及其生物学基础提供基础，并产生一个基准，据此可以衡量记忆干预和再培训的未来发展。