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Correlating Human Electrophysiology and BOLD Activity

将人体电生理学与 BOLD 活动关联起来

基本信息

批准号：
7242572
负责人：
ARNE D EKSTROM
金额：
$ 4.64万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-06-01 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7242572
关键词：
Address Area Behavior Behavioral Brain Brain Mapping Brain region Cell Nucleus Cells Cities Complex Computing Methodologies Condition Data Depth Electrodes Electroencephalography Electrophysiology (science)Ensure Epilepsy Event Excision Fire - disasters Functional Imaging Functional Magnetic Resonance Imaging Goals Hippocampus (Brain)Human Image Impairment Implant Intractable Epilepsy Knowledge Literature Magnetic Resonance Imaging Magnetism Medial Memory Methods Metric Neurons Parahippocampal Gyrus Patient Schedules Patients Pattern Performance Play Positioning Attribute Primates Property Rate Resolution Retrieval Rodent Role Sampling Seizures Signal Transduction Stimulus Structure System Techniques Temporal Lobe Testing Work base blood oxygen level dependent dentate gyrus design experience granule cell hemodynamics hippocampal subregions implantation insight memory recognition relating to nervous system research study response treatment planning virtual way finding

项目摘要

DESCRIPTION (provided by applicant): The goal of this proposal is to correlate the hemodynamic BOLD signal with cellular electrophysiological activity in the human medial temporal lobes. This project proposes to perform high-resolution structural imaging studies of the hippocampal area during performance of navigation tasks. Using computational methods that allow unfolding of activity in subregions of the brain, I will examine fMRI BOLD activity in the subnuclei of the hippocampus and specific layers of the parahippoccampal region. These same patients will subsequently be implanted with depth electrodes in these brain regions as part of resection planning for treatment of pharmacologically intractable epilepsy. Using an 128 channel recording system that allows continuous sampling of wide band electrophysiological data, both EEG and single neuron responses in the hippocampal area will be examined. By examining EEG and single neuron responses to behaviorally relevant events, these signals will then be correlated with the BOLD signal. Testing with control subjects will provide insight into which activations in patients may represent impairments due to seizures and can justify comparing our findings on correlations between BOLD and electrophysiology to normal brain activity.

描述(由申请人提供)：该方案的目标是将血流动力学BOLD信号与人类内侧颞叶的细胞电生理活动相关联。该项目建议在执行导航任务期间对海马区进行高分辨率结构成像研究。我将使用计算方法来展开大脑各亚区的活动，我将检查海马亚核和海马旁海马区特定层的fMRI BOLD活动。这些患者随后将在这些脑区植入深度电极，作为治疗药物难治性癫痫的切除计划的一部分。使用128个通道的记录系统，允许连续采样宽带电生理数据，将检查脑电和海马区单个神经元的反应。通过检查脑电和单个神经元对行为相关事件的反应，这些信号将与BOLD信号相关联。对对照对象的测试将提供对患者哪些激活可能代表癫痫发作所致损害的洞察，并可以证明我们关于BOLD和电生理学与正常大脑活动之间的相关性的发现是合理的。