Development of Unprecedented Aluminosilicate Adjuvants

高性能佐剂是疫苗技术的重要组成部分。铝基佐剂被广泛使用，但提供的细胞免疫力较弱，可能有神经毒性的风险。该项目结合了最新的纳米技术和经典的配位化学，旨在应用一种新的设计原则来创造新型的具有碱性的介孔铝硅酸盐纳米颗粒，作为纳米佐剂使用。该项目希望促进免疫系统如何对铝硅酸盐材料的化学和纳米结构变化做出反应的知识，并使设计具有增强细胞免疫和降低毒性的纳米佐剂成为可能。成果包括一系列具有前所未有的佐剂性能的新功能材料。

High-performance adjuvants are essential components of vaccine technology. Aluminium-based adjuvants are widely used, but provide weak cellular immunity and possible risk of neurotoxicity. Combining state-of-the-art nanotechnology and classic coordination chemistry, this project aims to apply a new design principle to create novel mesoporous aluminosilicate nanoparticles with alkalinity, for use as nanoadjuvants. This project expects to advance knowledge of how immune systems respond to changes in chemistry and nanostructure of aluminosilicate materials and enable the design of nanoadjuvants with enhanced cellular immunity and reduced toxicity. Outcomes include a new family of functional materials with unprecedented adjuvant performance.