Development of Unprecedented Aluminosilicate Adjuvants

前所未有的硅铝酸盐佐剂的开发

• 批准号: DP210102277
• 负责人: Prof Chengzhong Yu
• 金额: $ 25.32万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102277
• 关键词: Development; Unprecedented; Aluminosilicate; Adjuvants

High-performance adjuvants are essential components of vaccine technology. Aluminium-based adjuvants are widely used, but provide weak cellular immunity and possible risk of neurotoxicity. Combining state-of-the-art nanotechnology and classic coordination chemistry, this project aims to apply a new design principle to create novel mesoporous aluminosilicate nanoparticles with alkalinity, for use as nanoadjuvants. This project expects to advance knowledge of how immune systems respond to changes in chemistry and nanostructure of aluminosilicate materials and enable the design of nanoadjuvants with enhanced cellular immunity and reduced toxicity. Outcomes include a new family of functional materials with unprecedented adjuvant performance.

高性能佐剂是疫苗技术的重要组成部分。铝基佐剂被广泛使用，但提供较弱的细胞免疫和可能的神经毒性风险。该项目结合了最先进的纳米技术和经典的配位化学，旨在应用新的设计原理来制造具有碱性的新型介孔硅酸铝纳米颗粒，用于纳米佐剂。该项目旨在推进免疫系统如何对硅酸铝材料的化学和纳米结构变化作出反应的知识，并使纳米佐剂的设计具有增强细胞免疫力和降低毒性。结果包括具有前所未有的辅助性能的新功能材料家族。