Next-Generation Multifunctional Nanoparticles for mRNA Transfection

该项目旨在设计一种为信使核糖核酸传递量身定做的多功能纳米颗粒平台。将使用一种创新的组装方法来设计成分、不对称性和表面形貌可调的纳米颗粒。独一无二的是，三种功能将整合在一个纳米颗粒中，目的是提高目标细胞的转基因效率。该项目期望推进对信使核糖核酸转导机制的了解，并确定依赖细胞类型的颗粒-信使核糖核酸相互作用如何与纳米颗粒结构和传递性能相关。成果包括一系列新的功能材料，其信使核糖核酸传递性能比基准系统更好，以促进和扩大信使核糖核酸技术的应用。

This project aims to engineer a multifunctional nanoparticle platform tailored for mRNA delivery. An innovative assembly approach will be used to design nanoparticles with adjustable composition, asymmetry and surface topography. Uniquely, three functions will be integrated in one nanoparticle, with the goal to enhance transfection efficiency in target cells. This project expects to advance knowledge of mRNA transfection mechanisms, and determine how cell-type dependent particle-mRNA interactions correlate with the nanoparticle structure and delivery performance. Outcomes include a new family of functional materials with improved mRNA delivery performance over benchmark systems to facilitate and broaden the application of mRNA technology.