A Nano-platform for affordable and ultra-sensitive bio-marker detection

用于经济实惠且超灵敏的生物标志物检测的纳米平台

• 批准号: LP160101656
• 负责人: Prof Chengzhong Yu
• 金额: $ 20.82万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-10-17 至 2022-10-15
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160101656
• 关键词: Nano; platform; affordable; ultra; sensitive

This project aims to develop a next-generation nano-platform and lateral flow assays (LFA) device for ultra-sensitive detection of biomarkers. LFA’s are used for the rapid detection of biomarkers; however, their sensitivity is relatively low. The preparation of innovative porous silica nanoparticles with uniform particle size and controllable structures (pore size, pore structure, internal surface functionality and density) will enable higher loading of quantum dots and enhanced detection sensitivity. Improving the detection sensitivity of the inexpensive and disposable LFA diagnostic technology will open up new applications for rapid and accurate biomarker detection. The resulting technology will advance Australian industrial capability and competiveness in the global lateral flow assays market, which is estimated to be valued at US$ 6.78 billion by 2020.

该项目旨在开发下一代纳米平台和侧流分析（LFA）设备，用于生物标志物的超灵敏检测。LFA用于快速检测生物标志物;然而，它们的灵敏度相对较低。制备具有均匀粒度和可控结构（孔径、孔结构、内表面功能和密度）的创新多孔二氧化硅纳米颗粒将能够实现更高的量子点负载和增强的检测灵敏度。提高廉价和一次性LFA诊断技术的检测灵敏度将为快速和准确的生物标志物检测开辟新的应用。由此产生的技术将提高澳大利亚的工业能力和在全球侧向流分析市场的竞争力，预计到2020年，该市场的价值将达到67.8亿美元。