A New Platform of Bio-inspired Nanoparticles for Enhanced Cellular Delivery

用于增强细胞递送的仿生纳米颗粒新平台

• 批准号: DP140102237
• 负责人: Prof Chengzhong Yu
• 金额: $ 31.45万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102237
• 关键词: New; Platform; Bio; inspired; Nanoparticles

Delivery of various molecules into cells is crucial in modern medicine. Compared to viral vectors, non-viral vectors are safer delivery vehicles, but their delivery efficiency must be improved before they can be broadly used. Inspired by the surface topography of viruses with high infectivity, this project aims to provide a fundamental understanding of the impact of surface roughness on cellular delivery efficiency; and to use this knowledge in the designed synthesis of a new family of bio-inspired non-viral nanoparticles with both safety and high cellular delivery efficiency. The new and high performance nano-carriers will become a platform technology with broad bio-applications in gene therapy, cancer therapy and bio-imaging.

将各种分子递送到细胞中在现代医学中至关重要。与病毒载体相比，非病毒载体是一种更安全的载体，但其传递效率有待提高。受高感染性病毒表面形貌的启发，该项目旨在提供对表面粗糙度对细胞递送效率影响的基本理解;并将这些知识用于设计合成具有安全性和高细胞递送效率的新型生物启发非病毒纳米颗粒家族。新型高性能纳米载体将成为基因治疗、肿瘤治疗和生物成像等领域具有广泛应用前景的平台技术。