A New Platform of Bio-inspired Nanoparticles for Enhanced Cellular Delivery

在现代医学中，将各种分子送入细胞是至关重要的。与病毒载体相比，非病毒载体是更安全的载体，但在广泛应用之前，必须提高其传递效率。受高传染性病毒表面形貌的启发，该项目旨在提供对表面粗糙度对细胞递送效率的影响的基本了解；并将这些知识用于设计合成具有安全和高细胞递送效率的新的生物启发的非病毒纳米粒家族。新型高性能纳米载体将成为一种在基因治疗、癌症治疗和生物成像方面具有广泛生物应用的平台技术。

Delivery of various molecules into cells is crucial in modern medicine. Compared to viral vectors, non-viral vectors are safer delivery vehicles, but their delivery efficiency must be improved before they can be broadly used. Inspired by the surface topography of viruses with high infectivity, this project aims to provide a fundamental understanding of the impact of surface roughness on cellular delivery efficiency; and to use this knowledge in the designed synthesis of a new family of bio-inspired non-viral nanoparticles with both safety and high cellular delivery efficiency. The new and high performance nano-carriers will become a platform technology with broad bio-applications in gene therapy, cancer therapy and bio-imaging.