Mouse Production, Testing, and Research Support Core

项目摘要-鼠标生产、测试和研究支持核心(核心C) 核心C，鼠标生产、测试和研究支持核心，将提供鼠标和鼠标 在本计划项目中提出的所有四个研究项目中为学习提供服务。具体地说，核心将 扩大和管理突变和野生型小鼠的繁育群体，提供饲养和保健， 管理测试饲料，并确保将用于以下目的的所有小鼠的身份、可用性和可访问性 研究。此外，核心将采集、收集、标记、记录和保存组织和液体(例如，血液， 脑部)采集单个小鼠的样本，并将样本送到适当的项目(S)进行分析。此外， Core将负责在小鼠品系上进行特定的认知和行为表型测试。 最后，Core将提供使用阿尔茨海默病小鼠模型和 促进未来向临床应用的转化。从这些测试中收集和记录的数据将 交付给B核心、生物统计和生物信息学核心以及相关研究项目(S)，用于 分别进行分析和解释。核心C还将与核心A(管理核心)密切合作，以 精简和高效地协调所有四个研究项目之间的活动。它的技术和教职员工 凭借专业知识和承诺的计划基础设施，Core C为实现这些目标做好了独一无二的准备。

Project Summary – Mouse Production, Testing, and Research Support Core (Core C) Core C, the Mouse Production, Testing, and Research Support Core, will provide mice and mouse services for study in all four research projects proposed in this program project. Specifically, the Core will expand and manage breeding colonies of mutant and wildtype mice, provide husbandry and health care, administer test diets, and ensure the identity, availability, and accessibility of all mice that will be used for research. In addition, the Core will harvest, collect, label, record, and preserve tissue and fluid (e.g., blood, brain) samples from individual mice and deliver samples to the appropriate project(s) for analysis. Moreover, the Core will be responsible for conducting specific cognitive and behavioral phenotyping tests on mouse lines. Finally, the Core will provide expertise in preclinical studies using Alzheimer's disease mouse models and facilitate future translation to clinical applications. Data collected and recorded from these tests will be delivered to Core B, the Biostatistics and Bioinformatics Core and to the relevant research project(s) for analysis and interpretation, respectively. Core C will also work closely with Core A, the Administrative Core, to streamline and efficiently coordinate activities between all four research projects. With its technical and faculty expertise and committed program infrastructure, Core C is uniquely prepared to accomplish these objectives.