Mouse Production, Testing, and Research Support Core

项目概要-小鼠生产、测试和研究支持核心（核心C） 核心C，鼠标生产，测试和研究支持核心，将提供鼠标和鼠标 为本项目提出的四个研究项目的研究提供服务。具体而言，核心将 扩大和管理突变和野生型小鼠的繁殖群体，提供饲养和保健， 管理试验饲料，并确保将用于试验的所有小鼠的身份、可用性和可及性。 research.此外，核心将收获、收集、标记、记录和保存组织和流体（例如，血， 脑）样本，并将样本交付给适当的项目进行分析。此外，委员会认为， 核心将负责对小鼠品系进行特定的认知和行为表型测试。 最后，核心将提供使用阿尔茨海默病小鼠模型进行临床前研究的专业知识， 便于将来转化为临床应用。从这些测试中收集和记录的数据将 交付给核心B，生物统计学和生物信息学核心以及相关研究项目， 分析和解释。核心C还将与核心A（行政核心）密切合作， 简化并有效协调所有四个研究项目之间的活动。凭借其技术和师资力量 专业知识和承诺的计划基础设施，核心C是唯一准备实现这些目标。

Project Summary – Mouse Production, Testing, and Research Support Core (Core C) Core C, the Mouse Production, Testing, and Research Support Core, will provide mice and mouse services for study in all four research projects proposed in this program project. Specifically, the Core will expand and manage breeding colonies of mutant and wildtype mice, provide husbandry and health care, administer test diets, and ensure the identity, availability, and accessibility of all mice that will be used for research. In addition, the Core will harvest, collect, label, record, and preserve tissue and fluid (e.g., blood, brain) samples from individual mice and deliver samples to the appropriate project(s) for analysis. Moreover, the Core will be responsible for conducting specific cognitive and behavioral phenotyping tests on mouse lines. Finally, the Core will provide expertise in preclinical studies using Alzheimer's disease mouse models and facilitate future translation to clinical applications. Data collected and recorded from these tests will be delivered to Core B, the Biostatistics and Bioinformatics Core and to the relevant research project(s) for analysis and interpretation, respectively. Core C will also work closely with Core A, the Administrative Core, to streamline and efficiently coordinate activities between all four research projects. With its technical and faculty expertise and committed program infrastructure, Core C is uniquely prepared to accomplish these objectives.