The National Center for Metabolic Phenotyping of Mouse Models of Obesity and Diabetes (MPMOD) at UC Davis
加州大学戴维斯分校国家肥胖和糖尿病小鼠模型代谢表型中心 (MPMOD)
基本信息
- 批准号:10588971
- 负责人:
- 金额:$ 75.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-02-01 至 2028-01-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdultAge YearsAnimalsAnxietyAttentionAutopsyAwarenessBehaviorBioenergeticsBiomedical ResearchBody CompositionBusinessesCaliforniaCardiovascular systemCaringCenters for Disease Control and Prevention (U.S.)Chronic stressClientCommunitiesComplexConsultationsContinuous Glucose MonitorDataData AnalysesDevelopmentDiabetes MellitusDiabetic mouseDiagnosticDiseaseDisease modelEatingEnergy IntakeEnergy MetabolismEnvironmental Risk FactorEpidemicEvaluationExerciseExperimental DesignsFeasibility StudiesFee-for-Service PlansFeeding behaviorsFeesFoodFoundationsFunctional disorderFundingGeneticGnotobioticGoalsHealthHeart DiseasesHeterogeneityHispanic-serving InstitutionHistopathologyHumanImageImpaired cognitionIn VitroIncidenceIncomeInfrastructureInstitutionInternationalInvestmentsKidneyLearningMacronutrients NutritionMalignant NeoplasmsMeasuresMemoryMental DepressionMetabolicMetabolic DiseasesMetabolismMicrosurgeryModelingMorbidity - disease rateMotorMusMutant Strains MiceNational Institute of Diabetes and Digestive and Kidney DiseasesNeurologicNon-Insulin-Dependent Diabetes MellitusObesityOperative Surgical ProceduresOrganOutcome MeasureParticipantPathogenesisPersonsPhenotypePhysical activityPhysiologic ThermoregulationPhysiologicalPhysiologyPilot ProjectsPlasmaPopulationPositron-Emission TomographyPrediabetes syndromePrevalencePreventionPrevention strategyProceduresProductionReportingResearchResearch PersonnelResourcesRoleScientistSerumServicesSleepSolidSpecialistStressStrokeSurgical ModelsSystemTechnologyTestingTherapeuticTissuesTraining and EducationTranslatingTranslational ResearchUnderrepresented PopulationsUniversitiesWritingadult obesityagedbariatric surgerybehavior testbehavioral phenotypingclinically relevantcostdiabeticdisease diagnosiseconomic costenergy balanceexperienceexperimental studygastrointestinalhigh riskimaging capabilitiesimprovedin vivoinnovationmembermetabolic phenotypemicrobiomemouse modelneurobehavioralneurophysiologynovelpatient populationprogramsrepositoryrespiratoryresponsesobrietystatisticssuccesstraining opportunitywaiver
项目摘要
National Center for Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD)
at UC Davis
ABSTRACT—OVERALL SECTION
According to the Centers for Disease Control, more than a third of U.S. adults are obese, suffer related
complications (e.g., heart disease, stroke, cancer), and cost the US economy more than $150 billion annually.
And the facts don’t stop there: recent data from the CDC reveal an increasing incidence of type 2 diabetes,
reaching a prevalence of ~11% of the US adult population today. Genetics, environmental factors, food and
physical activity behaviors, chronic stress, and coincident high-risk morbidities all point to diabetes and obesity
being diseases of heterogenic origin. In this context, advanced research to comprehensively phenotype better
mouse models relevant to the human condition is especially needed to fully understand disease pathogenesis
and mechanisms to inform strategies for curbing this rising epidemic.
Translational research in vivo using genetic, surgical, humanized, and other types of mouse models are
needed especially now to characterize disease pathogenesis, mechanisms, and consequences. These models
need to be relevant to the pathophysiology of human metabolic disease so as to inform more effective
diagnostic, therapeutic, and prevention strategies. To catalyze this effort and accelerate progress toward these
goals, UC Davis proposes the creation of a National Center for Metabolic Phenotyping of Mouse Models of
Obesity and Diabetes (MPMOD). The Center will provide the diabetes and obesity research communities
access to specialized and advanced resources to assess mouse models employing unique, complex, and
hard-to-find tests and procedures. MPMOD users will also be connected to competent, experienced, and
expert consultation and advice on experimental design, test selection, outcomes measures, and interpretation.
The UC Davis MPMOD team has a solid foundation of service to the research community: for the last 10
years, UC Davis served as a flagship in the NIDDK Metabolic Mouse Phenotyping Center (MMPC)
Consortium, providing in vivo services on live mice and in vitro analyses on murine tissue and plasma and
serum to the greater research community. The MPMOD Center at UC Davis will build from those successes
and our strong infrastructure to offer many novel and innovative approaches to tackle new questions in live
mice, drawing upon the larger UC Davis scientific enterprise and core labs to provide the research community
with high quality metabolic, physiologic, and behavioral phenotyping services in vivo to characterize the
heterogeneity, pathogenesis, and consequences of diabetes, obesity, and related metabolic disorders.
The MPMOD Center at UC Davis will consist of an Administrative Core providing administrative, service,
and business oversight for the Center; an Animal Core that will import and provide husbandry, care, and
numerous special services (e.g., SPF husbandry, gnotobiotic mouse management, ABSL3 conditions,
microsurgery capability, necropsy and histopathology) for mice submitted to the Center; a Metabolism and
Metabolic Health Core with significant resources and expertise to offer well-established metabolic phenotyping
tests plus innovative approaches (e.g., PET imaging, continuous glucose monitoring, sophisticated energy
balance measures, xenometabolomics) to reveal subtle shifts in macronutrient metabolism, energy intake and
feeding behaviors, energy expenditure and metabolic efficiency; and a Physiology and Behavior Core with
substantial breadth and depth of expertise and capabilities to provide in-depth assessments of organ and
whole-animal physiology (cardiovascular, gastrointestinal, renal, respiratory, ocular, and neurological) and
neurobehavioral assessment of exercise behavior, sleep, learning and memory, anxiety, depression and
stress, and motor function relevant to diabetes and obesity. Each of the Cores will have a Scientific Leader and
co-Leader, Core Coordinator, and Technical Specialists to conduct experiments. Numerous Scientific
Consultants affiliated with each Core will be available to offer expert advice on experimental design, test
selection, and data interpretation, and provide novel and complex tests and procedures upon request.
In addition to comprehensive tests and consultation, a major strength of the MPMOD Center at UC Davis
will be a close association with internationally recognized assets for production and sharing of novel mouse
disease models. Scientists can of course send in their own mice for testing, but in addition they can order a
mouse model of diabetes or obesity from a repository (e.g., the UC Davis MMRRC, KOMP2 programs) or have
the Center make a relevant mouse model de novo (e.g., genetically-altered, bariatric surgery model) for them.
Services will be offered at reasonable cost to all users who will be afforded equal service priority whether
from inside UC Davis or an outside institution. The Center will reinvest program income to develop new testing
technologies, fund collaborative projects, support fee waivers, and subsidize pilot and feasibility studies. The
Center intends to be an active and engaged member of the MPMOD Consortium by participating in shared
governance of the national MPMOD Program and by providing complementary services to avoid costly and
inefficient overlap between other MPMOD Centers. Finally, the Center will be an active participant in the
MPMOD Vibrant Program and has proposed an innovative partnership between MPMOD Centers and
Hispanic Serving Institutions (HSIs) in the 23-campus California State University (CSU) system.
国家肥胖和糖尿病活体模型代谢表型研究中心(MPMOD)
在加州大学戴维斯
摘要-总体部分
根据疾病控制中心的数据,超过三分之一的美国成年人患有肥胖症,
并发症(例如,心脏病、中风、癌症),每年给美国经济造成的损失超过1500亿美元。
事实还不止于此:CDC最近的数据显示,2型糖尿病的发病率正在上升,
目前美国成年人口中的患病率约为11%。遗传、环境因素、食物和
体力活动行为、慢性压力和同时发生的高风险疾病都指向糖尿病和肥胖
是异源性疾病。在此背景下,先进的研究,以全面表型更好
特别需要与人类状况相关的小鼠模型,以充分了解疾病的发病机制
以及为遏制这一日益严重的流行病的战略提供信息的机制。
使用遗传、手术、人源化和其他类型的小鼠模型进行体内转化研究,
现在特别需要描述疾病的发病机理、机制和后果。这些模型
需要与人类代谢疾病的病理生理学相关,以便提供更有效的信息
诊断、治疗和预防战略。为了促进这一努力,并加快实现这些目标的进展,
目标,加州大学戴维斯分校建议建立一个国家中心的代谢表型的小鼠模型,
肥胖和糖尿病(MPMOD)。该中心将为糖尿病和肥胖研究社区提供
获得专业和先进的资源,以评估采用独特的,复杂的,
难以找到的测试和程序。MPMOD用户还将连接到有能力的,有经验的,
关于实验设计、测试选择、结果测量和解释的专家咨询和建议。
加州大学戴维斯分校MPMOD团队为研究界提供坚实的服务基础:在过去的10年中
多年来,加州大学戴维斯分校担任NIDDK代谢小鼠表型中心(MMPC)的旗舰
联合会,提供活小鼠的体内服务和小鼠组织和血浆的体外分析,
研究界的精英加州大学戴维斯分校的MPMOD中心将在这些成功的基础上建立
以及我们强大的基础设施,提供许多新颖和创新的方法来解决生活中的新问题
小鼠,利用更大的加州大学戴维斯分校的科学企业和核心实验室,以提供研究社区
通过高质量的代谢、生理和行为表型分析服务,
糖尿病、肥胖症和相关代谢紊乱的异质性、发病机制和后果。
加州大学戴维斯分校的MPMOD中心将包括一个行政核心,提供行政,服务,
中心的业务监督;一个动物核心,将进口和提供畜牧业,护理,
许多特殊服务(例如,SPF饲养,无菌小鼠管理,ABSL 3条件,
显微外科手术能力、尸检和组织病理学); a代谢和
代谢健康核心拥有丰富的资源和专业知识,可提供完善的代谢表型分析
测试加上创新方法(例如,PET成像、连续葡萄糖监测、复杂的能量
平衡措施,异种代谢组学),以揭示微量营养素代谢,能量摄入和
摄食行为,能量消耗和代谢效率;以及生理和行为核心,
具有相当广度和深度专门知识和能力,
整体动物生理学(心血管、胃肠道、肾脏、呼吸系统、眼部和神经系统)和
运动行为、睡眠、学习和记忆、焦虑、抑郁和
压力以及与糖尿病和肥胖症相关的运动功能。每个核心将有一个科学领导人,
共同领导人,核心协调员和技术专家进行实验。许多科学
每个核心的附属顾问将提供关于实验设计、测试和评估的专家建议。
选择和数据解释,并根据要求提供新颖和复杂的测试和程序。
除了全面的测试和咨询外,加州大学戴维斯分校MPMOD中心的一个主要优势是
将与国际公认的生产和共享新型鼠标资产的密切联系
疾病模型科学家当然可以送他们自己的老鼠去做测试,但除此之外,他们还可以订购一个
来自储存库的糖尿病或肥胖症小鼠模型(例如,加州大学戴维斯分校MMRRC,KOMP 2计划)或具有
该中心从头制作相关小鼠模型(例如,基因改变的减肥手术模型)。
服务将以合理的价格提供给所有用户,他们将获得同等的服务优先权,
加州大学戴维斯分校内部或外部机构该中心将把项目收入再投资于开发新的测试
技术,资助合作项目,支持费用减免,并补贴试点和可行性研究。的
中心打算通过参与共享的MPMOD联盟,成为MPMOD联盟的积极参与成员。
管理国家MPMOD计划,并提供补充服务,以避免昂贵的,
其他MPMOD中心之间的低效重叠。最后,本中心将积极参与
MPMOD充满活力的计划,并提出了MPMOD中心和
西班牙裔服务机构(HSIs)在23个校园加州州立大学(CSU)系统。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KC KENT LLOYD其他文献
KC KENT LLOYD的其他文献
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{{ truncateString('KC KENT LLOYD', 18)}}的其他基金
Equipment and Instrument Infrastructure Improvement for the MMRRC at UC Davis
加州大学戴维斯分校 MMRRC 的设备和仪器基础设施改进
- 批准号:
10805721 - 财政年份:2023
- 资助金额:
$ 75.88万 - 项目类别:
MMPC-Live Consortium Marketing and Outreach
MMPC-Live 联盟营销和推广
- 批准号:
10901723 - 财政年份:2023
- 资助金额:
$ 75.88万 - 项目类别:
MMRRC COVID-19 variant testing in humanized mouse models
MMRRC 在人源化小鼠模型中进行 COVID-19 变异测试
- 批准号:
10412858 - 财政年份:2021
- 资助金额:
$ 75.88万 - 项目类别:
Mouse Production, Testing, and Research Support Core
鼠标生产、测试和研究支持核心
- 批准号:
10398861 - 财政年份:2019
- 资助金额:
$ 75.88万 - 项目类别:
Mouse Production, Testing, and Research Support Core
鼠标生产、测试和研究支持核心
- 批准号:
10685453 - 财政年份:2019
- 资助金额:
$ 75.88万 - 项目类别:
Mouse Production, Testing, and Research Support Core
鼠标生产、测试和研究支持核心
- 批准号:
10153623 - 财政年份:2019
- 资助金额:
$ 75.88万 - 项目类别:
Replacement of Pass Through Autoclave Sterilizer Within A High Health Status Barrier Vivarium- Building M3 UC Davis
更换高健康状况屏障 Vivarium- Building M3 UC Davis 内的通过式高压灭菌器
- 批准号:
9120041 - 财政年份:2016
- 资助金额:
$ 75.88万 - 项目类别:
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