Replacement of Pass Through Autoclave Sterilizer Within A High Health Status Barrier Vivarium- Building M3 UC Davis

更换高健康状况屏障 Vivarium- Building M3 UC Davis 内的通过式高压灭菌器

• 批准号: 9120041
• 负责人: KC KENT LLOYD
• 金额: $ 49.94万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9120041
• 关键词: Affect; Animal Housing; Animals; Bariatrics; Beds; Bottle feeding; California; Ensure; Equipment; Equipment Failure; Failure; Funding; Future; Genetically Modified Animals; Genomics; Grant; Health; Health Status; Housing; Immune; Knockout Mice; Lead; Life Expectancy; Monitor; Mus; Mutant Strains Mice; Research; Research Infrastructure; Research Personnel; Resources; Rodent; Sentinel; Shipping; Ships; Social Welfare; Steam; Surgical Models; United States National Institutes of Health; Universities; Vendor; Water; biosecurity; improved; infrastructure development; metabolic phenotype; operation; prevent; programs; repaired; repository

 DESCRIPTION (provided by applicant): The M3 Targeted Genomics Facility Vivarium Housing unit is the only high health status barrier rodent housing facility on the University of California Davis (UC Davis) Campus and is in dire need of replacement of the facility dedicated bulk pass-through autoclave sterilizer. The biosecurity of the M3 barrier vivarium is dependent on the operational function of this critical piece of equipment which is over 40 years old and has been assessed and demonstrated to have irreparable damage which will lead to eminent equipment failure and subsequent facility operational failure jeopardizing the animal health and welfare of those animals housed within. The M3 facility supports 38 UC Davis investigators with active grant and internal campus support totaling approximately $10.5 million. All supplies, caging, bedding, feed, and bottles are autoclaved into the facility to ensure the strict health status of the genetically modified animals and immune compromised rodent colonies housed in the M3 barrier vivarium. The M3 barrier vivarium serves as the High health "vendor status barrier" for shipping associated with several large NIH funded grant repository projects (Mutant Mouse Resource and Research Center, Knockout Mouse Project Repository, and the Bariatric Surgical Model Distribution for the Mouse Metabolic Phenotyping Center). The M3 barrier housing facility also houses the campus colony which supplies all rodent sentinel animals for the UC Davis Campus Rodent Health Monitoring Program. Thus, the impact of the operations of the M3 barrier facility reach beyond the animals housed within the facility and affect all mouse related research across the UC Davis campus. The current autoclave is over 40 year old and has been used past its life expectancy. Damage from several years of inadequate steam supply due to lack of infrastructure development have led to cracks in the jacket of the autoclave which can't be repaired. Funds are being requested for replacement of the bulk pass through autoclave sterilizer as well as additional dedicated electric boiler support for the new equipment to prevent excessive wear and tear from inadequate central steam infrastructure. The new autoclave will be more energy efficient, water saving, and improve operational efficiency in order to support the growing use of the M3 Targeted Genomics Vivarium Facility. This will ensure the biosecurity, welfare, and health of current and future rodent projects reliant on the health status that this vivarium housing facility provides.

 描述（由申请人提供）：M3靶向基因组学设施动物饲养室是加州戴维斯大学（UC Davis）校区唯一的高健康状况屏障啮齿动物饲养设施，急需更换设施专用的批量直通高压灭菌器。M3屏障动物园的生物安全性取决于该关键设备的操作功能，该设备已使用40年以上，经评估并证明存在不可修复的损坏，将导致显著的设备故障和后续设施操作故障，危及动物健康和饲养动物的福利。M3设施为38名加州大学戴维斯分校研究人员提供总计约1，050万美元的主动拨款和内部校园支持。所有用品、笼养、床上用品、饲料和瓶子都在设施中经过高压灭菌，以确保M3屏障动物园中饲养的转基因动物和免疫受损啮齿动物群落的严格健康状态。M3屏障动物园作为高健康“供应商身份屏障”，用于与几个大型NIH资助的资助库项目（突变小鼠资源和研究中心、敲除小鼠项目库和小鼠代谢表型中心的肥胖症手术模型分布）相关的运输。M3屏障住房设施还设有校园殖民地，为加州大学戴维斯分校校园啮齿动物健康监测计划提供所有啮齿动物哨兵。因此，M3屏障设施的运行影响超出了设施内饲养的动物，并影响了整个加州大学戴维斯分校校园的所有小鼠相关研究。目前的高压灭菌器已超过40年，并且已超过其预期寿命。由于缺乏基础设施发展，几年来蒸汽供应不足造成的损坏导致高压釜夹套出现裂缝，无法修复。正在请求提供资金，用于更换散装通过式高压灭菌器，并为新设备提供额外的专用电锅炉支持，以防止中央蒸汽基础设施不足造成过度磨损。新的高压灭菌器将更加节能，节水，并提高运营效率，以支持M3靶向基因组学动物园设施的日益增长的使用。这将确保当前和未来啮齿动物项目的生物安全、福利和健康， 动物园提供的食物。