Translational Control: Discovery and Mechanisms
翻译控制:发现和机制
基本信息
- 批准号:10152613
- 负责人:
- 金额:$ 56.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-05-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:Antibiotic ResistanceAntibioticsBacterial InfectionsCommunicable DiseasesGene ExpressionGene Expression RegulationGenetic DiseasesGenetic TranscriptionMessenger RNAMolecularMutationNonsense MutationOrganismPathogenesisPathogenicityProteinsRegulationRibosomesSignal TransductionStressStructureTerminator CodonTranslation InitiationTranslationsViralVirusVirus Diseasesbacterial geneticsbiological adaptation to stressemerging antibiotic resistancefight againstimprovedinfectious disease treatmentnovel therapeutics
项目摘要
Project Summary/Abstract
Ribosomes are at the center of gene expression regulation. Not only do they synthesize
proteins, but they regulate transcription and respond to stress signals. The translational control
underlies the pathogenesis of infectious and genetic diseases. Translation is a key antibiotic
target, but the emergence of antibiotic resistance poses a serious challenge in the fight against
infectious diseases. To improve our understanding of the translational control of gene
expression in molecular detail, we propose to elucidate the structural mechanisms of (1)
translation initiation of viral mRNAs and virus-like cellular mRNAs; (2) bacterial stress responses
which couple translation with transcription, conferring bacterial pathogenicity and antibiotic
resistance and (3) translation elongation and termination. Understanding these mechanisms
may enable discovery of novel drugs for the treatment of viral or bacterial infections or genetic
diseases caused by nonsense mutations.
项目摘要/摘要
核糖体是基因表达调控的中心。它们不仅合成了
蛋白质,但它们调节转录并对压力信号做出反应。平移控制
是传染病和遗传性疾病发病机制的基础。翻译是关键的抗生素
靶标,但抗生素耐药性的出现对抗击
传染病。为了提高我们对基因翻译控制的理解
在分子细节上的表达,我们建议阐明(1)的结构机制。
病毒mRNAs和病毒样细胞mRNAs的翻译起始;(2)细菌应激反应
它将翻译和转录结合在一起,赋予细菌致病性和抗生素
阻力和(3)平移伸长和终止。了解这些机制
可能使发现治疗病毒或细菌感染或遗传病的新药成为可能
由无义突变引起的疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Andrei Korostelev其他文献
Andrei Korostelev的其他文献
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{{ truncateString('Andrei Korostelev', 18)}}的其他基金
Molecular principles of stringent response activation in bacteria
细菌严格反应激活的分子原理
- 批准号:
10453921 - 财政年份:2021
- 资助金额:
$ 56.38万 - 项目类别:
Structural bases for cellular stress responses mediated by stalled translation
翻译停滞介导的细胞应激反应的结构基础
- 批准号:
8595445 - 财政年份:2013
- 资助金额:
$ 56.38万 - 项目类别:
Structural bases for cellular stress responses mediated by stalled translation
翻译停滞介导的细胞应激反应的结构基础
- 批准号:
8708911 - 财政年份:2013
- 资助金额:
$ 56.38万 - 项目类别:
Structural bases for cellular stress responses mediated by stalled translation
翻译停滞介导的细胞应激反应的结构基础
- 批准号:
8858644 - 财政年份:2013
- 资助金额:
$ 56.38万 - 项目类别:
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