Centers for Medical Countermeasures Against Radiation

放射线医疗对策中心

• 批准号: 10152499
• 负责人: Nelson J. Chao
• 金额: $ 259.46万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10152499
• 关键词: Academic Medical Centers; Accidents; Acute; Address; Animal Model; Applied Research; Area; Basic Science; Biology; Centers of Research Excellence; Dedications; Development; Education; Exposure to; Fertilization; Fostering; Funding; Goals; Health Physics; Hematopoietic; Hour; Human; Immunology; Individual; Injury; Innate Immune Response; Interdisciplinary Study; Knowledge; Lead; Medical; Medical center; Myelogenous; Normal tissue morphology; North Carolina; Nuclear; Nuclear Warfare; Phosphotransferases; Physics; Population; Radiation; Radiation Dose Unit; Radiation Injuries; Radiation induced damage; Radioactive; Radiobiology; Radiology Specialty; Research; Research Personnel; Research Project Grants; Scientist; Secondary to; Terrorism; Time; Tissues; Toxic effect; Training and Education; Translational Research; Transplantation; Universities; War; Work; cancer therapy; driving force; extracellular vesicles; forest; gastrointestinal system; gut microbiome; in vitro Assay; injury and repair; innovative technologies; inter-institutional; irradiation; medical countermeasure; member; novel; novel therapeutics; predictive modeling; prevent; programs; radiation countermeasure; radiation effect; radiation-induced injury; radiological attack; radiological weapon; research and development; response; stem cell biology; tissue injury; trafficking

Summary Concerns about global nuclear war, less likely than in the past, have been replaced by the real potential of a terrorist strike using radiological weapons. The threat of such attacks has grown in recent years, with the increased activity of global terrorist organizations and a rise in illicit trafficking of radioactive materials. Unfortunately, very few medical products exist to counter the variety of acute and long-term toxicities that can result from nuclear or radiological attacks. There remains a great need to expand the medical options available to prevent or treat radiation-induced injury. We have formed a consortium termed Radiation Countermeasures Centers of Research Excellence (RadCCORE) to collectively and collaboratively increase possible agents to detect, mitigate and treat those people exposed to deterministic doses of radiation (www.radccore.org/). Leading scientists in the area of radiation biology, health physics, stem cell biology/transplantation and immunology have come together to form one of the most comprehensive, inclusive, inter-institutional, and interdisciplinary Center for Medical Countermeasures Against Radiation (CMCR). RadCCORE is a network of academic medical centers: Duke University, University of North Carolina, and Wake Forest University and will consist of four research projects and four support cores. A major benefit of this group of investigators has been the dedication and strength of the individuals in the areas of normal tissue injury, radiation biology, physics, training and education. Given that most of our lead compounds have progressed through the development pipeline and are now externally funded, we have selected a new set of promising countermeasures. This arrangement brings novel investigators, increased basic and translational science knowledge and novel mitigators to our center. This network addresses broad areas of research and has made great strides in the development of new therapeutic products to prevent short- and long-term toxicities.

总结 对全球核战争的担忧，不像过去那么可能，已经被一个真实的潜力所取代。 恐怖分子使用放射性武器发动袭击。近年来，这种攻击的威胁有所增加， 全球恐怖组织活动增加，非法贩运放射性材料活动增加。 不幸的是，很少有医疗产品可以对抗各种急性和长期毒性， 核武器或放射性武器的攻击。仍然非常需要扩大现有的医疗选择 以预防或治疗辐射引起的损伤。我们成立了一个叫辐射对策的联盟 卓越研究中心（RadCCORE）共同合作，增加可能的代理人， 检测、减轻和治疗受确定剂量辐射的人（www.radccore.org/）。 辐射生物学、健康物理学、干细胞生物学/移植和 免疫学已经走到一起，形成一个最全面的，包容性，机构间， 辐射医学对策中心（CMCR）。RadCCORE是一个网络， 学术医疗中心：杜克大学、北卡罗来纳州大学和维克森林大学， 由四个研究项目和四个支持核心组成。这组调查人员的一个主要好处是， 在正常组织损伤，放射生物学， 物理、培训和教育。考虑到我们的大部分先导化合物都是通过 开发管道，现在外部资助，我们已经选择了一套新的有前途的 对策这种安排带来了新的研究人员，增加了基础和转化科学 知识和新的缓和剂到我们的中心。该网络涉及广泛的研究领域， 在开发新的治疗产品以预防短期和长期毒性方面取得了长足进步。