INNOVATIVE NURSERY-REARING FOR IMPROVING RHESUS MACAQUES AS BIOMEDICAL MODELS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 国家研究资源中心(NCRR)的一个主要目标是在NCRR资助的灵长类中心为无特定病原体(SPF)的猕猴保持成功的繁殖计划，这些猕猴没有常见的逆转录病毒，这些逆转录病毒可能会干扰艾滋病实验和其他类型的研究。目前，SPF群体是通过在没有非SPF母亲的情况下抚养婴儿来建立的。因此，建立和维持这些SPF群体的长期成功的关键是制定有效的策略，以最大限度地减少由于社会剥夺其母亲而导致的行为病理的出现，并将导致社会能力的发展。这项拟议的研究将导致开发一种互动的代孕-同伴养育设计，该设计将为婴儿提供依恋图形以及与依恋图形(代孕)和同伴的反应-应急关系。在早期发育阶段提供这些特征应该会导致养育的婴儿比没有这些特征的养育的婴儿具有更正常的社交、运动、感知和认知技能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major goal of the National Center for Research Resources (NCRR) is to maintain successful breeding programs at NCRR-funded primate centers for specific-pathogen-free (SPF) macaque monkeys that are free of common retroviruses that can interfere with AIDS experiments and other types of research. SPF colonies are currently established by raising infants without their non-SPF mothers. Therefore, key to the long-term success of establishing and maintaining these SPF colonies is to develop efficacious strategies for raising infant monkeys in ways which minimize the emergence of behavioral pathologies due to social deprivation of their mothers and which will lead to the development of social competence. The proposed study will lead to the development of an interactive surrogate-peer rearing design that will provide both an attachment figure to the infant as well as response-contingency relationships with the attachment figure (surrogate) and peers. Providing these features during early development should result in nursery-reared infants with more normal social, motor, perceptual and cognitive skills than nursery-reared infants without these features.