Postdoctoral training in genomic medicine research

该NRSA应用程序的总体目标是为以下人员提供高质量的指导培训体验 在快速发展的基因组和精准医学领域有前途的临床和转化研究人员 获得知识和技能，使他们能够成功地建立独立的临床研究 程序.未来的基因组医学研究者将需要专业培训的坚实基础， 继续做出新的发现，并发展转化研究计划，使 将新的基因组发现应用于临床护理。我们建议进行为期2年的博士后培训 计划，为学员提供一系列的研究机会，在应用临床和转化基因组学 医学研究（湿或干实验室），生物信息学和计算生物学，工程学和统计学， 符合条件的申请人具有医学博士或博士学位。我们要求在第一年有2个培训名额，之后有4个名额。在 杜克至少有三个现有的或拟议的T32项目将利用NIH为该T32项目提供一个名额 投资这个项目。杜克致力于基因组医学的跨学科研究， 在生命科学领域有前途和多样化的博士后研究员。我们召集了27位资深的 研究人员作为导师和24名初级研究人员作为共同导师为这个计划。指导研究 经验将要求受训者在项目主任（PD）的协助下， 由2或3名导师组成的跨学科指导团队，指导他们的研究计划和职业生涯 发展研究培训经验将旨在提供专业培训，并将 考虑他们的研究所影响的更广泛的问题，包括伦理，法律的和社会影响。支持 他们的研究将是选择研究技术的实验室轮换、一套课程作业和非正式的 学习机会。在基因组学，临床研究，统计学和伦理学的最低核心课程必须 由每个受训者完成;可选修额外课程以支持受训者的研究 专心点学员将被要求每季度与PD会面。受训人员与他/她的定期会议 指导小组将提供持续的进度评估，并由项目主任报告和评估 以及该计划的执行委员会学员将被要求在杜克大学展示他们的研究成果 他还在国际会议和国家会议上发言，并为同行审查的出版物提交手稿。营商友导 团队和执行委员会将协助每一位学员申请助学金机会，并获得一个职位， 学术界或相关部门的奖学金教师职位，将允许继续他/她的研究。 受训者必须花费至少75%的努力，而他们的支持;受训者的临床经验将是 高度关注基因组医学在杜克大学基因组医学实践环境中的实践。 该计划的学员将受益于杜克丰富的高度跨学科的资源， 临床和转化基因组医学研究，并建立在其强大的历史和经验，在后， 博士培训。

The overarching goal of this NRSA application is to provide a high quality mentored training experience for promising clinical and translational researchers in the rapidly growing area of genomic and precision medicine to gain the knowledge and skills to enable them to successfully establish independent clinical research programs. Future genomic medicine investigators will require a strong foundation of specialized training to continue making new discoveries and to develop the translational research programs that enable implementation of new genomic discoveries into clinical care. We propose a 2-year postdoctoral training program, offering trainees a range of research opportunities in applied clinical and translational genomic medicine research (wet or dry lab), bioinformatics and computational biology, engineering, and statistics to eligible applicants with an MD or PhD. We are requesting 2 training slots in Year 1, and 4 slots thereafter. At least three existing or proposed T32 programs at Duke will donate a slot to this T32 leveraging the NIH investment in this program. Duke’s commitment to interdisciplinary research in genomic medicine will attract promising and diverse post-doctoral fellows across the life sciences. We have assembled 27 senior investigators as mentors and 24 junior investigators as co-mentors for this program. The mentored research experience will require trainees to establish, with the assistance of the program directors (PDs), an interdisciplinary mentoring team consisting of 2 or 3 mentors to guide their research program and career development. The research training experience will be designed to provide specialized training and will also consider broader issues impacted by their research including ethical, legal, and social implications. Supporting their research will be laboratory rotations for select research techniques, a suite of coursework and informal learning opportunities. A minimal core set of courses in genomics, clinical research, statistics and ethics must be completed by each trainee; additional elective courses may be taken to support the trainee’s research focus. Trainees will be required to meet with the PDs quarterly. Regular meetings of the trainee and his/her mentorship team will provide ongoing assessment of progress that will be reported and evaluated by the PDs and the program’s Executive Committee. Trainees will be required to present their research at Duke conferences and at national meetings and submit manuscripts for peer-reviewed publications. The mentorship team and the Executive Committee will assist each trainee to apply for grant opportunities and obtain a post- fellowship faculty position in academia or relevant sector that will allow continuation of his/her research. Trainees must spend at least 75% effort while they are supported; the trainees’ clinical experience will be highly focused on the practice of genomic medicine in genomic medicine practice environments at Duke. Trainees in this program will benefit from the rich and highly interdisciplinary resources available at Duke for clinical and translational genomic medicine research and build upon its strong history and experience in post- doctoral training.