Reproductive Development from Gonads to Fetuses

从性腺到胎儿的生殖发育

• 批准号: 10163223
• 负责人: Kyle Edwin Orwig
• 金额: $ 16.33万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-09 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10163223
• 关键词: Fetus; gonad development; reproductive development

PROJECT SUMMARY/ABSTRACT Discoveries in reproductive biology have had a remarkable impact in science and medicine, leading to several Nobel prizes in Physiology or Medicine in the past decade. Despite these advances in science that were produced by experts in the reproductive biology, the number of reproductive science trainees is dwindling at an alarming rate. To help reverse this trend, we have established this T32 Training Program in Reproductive Development from Gonads to Fetuses (RDGF). The purpose of this program is to tap the large, diverse and highly qualified pipeline of graduate students (PhD or MD/PhD) and postdoctoral fellows (MD or PhD) that matriculate at the University of Pittsburgh each year and recruit them to pursue training and careers in the reproductive sciences. This training program will enhance the recruitment of reproductive biology researchers into the unique environment at Magee-Womens Research Institute where graduate students, postdoctoral fellows, medical residents, medical fellows and junior faculty (119 total trainees) work side by side in state of the art research facilities and experience on a daily basis how fundamental research discoveries impact reproductive medicine and patient care. The overarching objectives of the Program are to select and recruit the most qualified candidates (3 PhD students and 3 postdocs/year) into the reproductive sciences and pair them with well-funded, productive mentors who are committed to the training mission of the program and the University of Pittsburgh/Magee. The program will provide trainees with the education, resources and technical experience to conduct impactful science, while adhering to the principles of responsible conduct of research and scientific integrity. Rigorous oversight and progress review of Trainee/Mentor teams will ensure that trainees are fully immersed in all aspects of academic career development, including career development coursework, publications, grant submissions and attendance/presentation at local and national/international meetings. Research productivity milestones (e.g., publications, grants and awards) combined with connections made in the reproductive biology community at meetings will set the stage for advancement to the next stage of career development. Full immersion of trainees in all aspects of their academic endeavors will endow them with a sense of ownership of their research productivity and increase the likelihood that they will be retained long-term in reproductive science-related careers. Graduate students (PhD or MD/PhD) can remain in the training program for a maximum of five years and postdoctoral fellows can remain in the program for a maximum of three years. However, our program requires that all trainees write and submit and individual training grant application during their second year of training. This is a valuable skill for a career in science and the turnover as trainees transition from institutional to individual awards will help maximize the number of trainees and impact of the program. We anticipate training a total of 6 graduate students and 6 postdoctoral trainees during the five year award period.

项目总结/摘要 生殖生物学的发现对科学和医学产生了巨大的影响， 诺贝尔生理学或医学奖在过去的十年。尽管科学的进步 由于生殖生物学专家的努力，生殖科学培训生的人数正在以每年100万人的速度减少， 惊人的速度。为了帮助扭转这一趋势，我们建立了T32生殖培训计划， 从性腺到胎儿的发育（RDGF）。该计划的目的是挖掘大型，多样化和 高素质的研究生（博士或医学博士/博士）和博士后研究员（医学博士或博士）， 每年在匹兹堡大学录取，并招募他们在 生殖科学这项培训计划将加强生殖生物学研究人员的招聘 进入马吉妇女研究所的独特环境，研究生，博士后 研究员、住院医师、医学研究员和初级教员（共119名受训人员）在 艺术研究设施和经验，每天的基础研究发现如何影响 生殖医学和病人护理。该计划的总体目标是选择和招募 最合格的候选人（3名博士生和3名博士后/年）进入生殖科学和对 他们与资金充足，富有成效的导师谁是致力于该计划的培训使命和 匹兹堡大学/Magee。该计划将为学员提供教育，资源和技术 经验进行有影响力的科学，同时坚持负责任的研究行为的原则 和科学诚信。对受训人员/导师团队进行严格的监督和进度审查，以确保 学员完全沉浸在学术职业发展的各个方面，包括职业发展 课程作业、出版物、赠款提交和出席/在地方和国家/国际会议上的演讲 会议.研究生产力里程碑（例如，出版物、赠款和奖励）， 生殖生物学界在会议上提出的建议将为进入下一阶段奠定基础 职业发展。学员完全沉浸在他们的学术努力的各个方面将赋予他们 拥有自己的研究生产力，并增加他们将被保留的可能性 长期从事生殖科学相关职业。研究生（PhD或MD/PhD）可以留在 培训计划最长为五年，博士后研究员可以留在该计划为 最多三年。然而，我们的计划要求所有学员写和提交和个人 在第二年培训期间申请培训补助金。这是从事科学事业的宝贵技能 以及学员从机构奖项过渡到个人奖项的更替，将有助于最大限度地增加 学员和方案的影响。预计培养研究生6名，博士后6名 在五年的奖励期内。

项目成果

Transport and Permeation Properties of Dapivirine: Understanding Potential Drug-Drug Interactions.

• DOI: 10.3390/pharmaceutics14091948
• 发表时间: 2022-09-14
• 期刊: Pharmaceutics
• 影响因子: 5.4
• 作者: Zheng R;Valicherla GR;Zhang J;Nuttall J;Silvera P;Marshall LJ;Empey PE;Rohan LC
• 通讯作者: Rohan LC

Investigating the Contribution of Drug-Metabolizing Enzymes in Drug-Drug Interactions of Dapivirine and Miconazole.

研究药物代谢酶在dapivirine和Miconazole的药物相互作用中的贡献。

• DOI: 10.3390/pharmaceutics13122193
• 发表时间: 2021-12-18
• 期刊: Pharmaceutics
• 影响因子: 5.4
• 作者: Valicherla GR;Graebing P;Zhang J;Zheng R;Nuttall J;Silvera P;Rohan LC
• 通讯作者: Rohan LC

Intestinal microbial circadian rhythms drive sex differences in host immunity and metabolism.

• DOI: 10.1016/j.isci.2023.107999
• 发表时间: 2023-10-20
• 期刊: ISCIENCE
• 影响因子: 5.8
• 作者: Munyoki, Sarah K.;Goff, Julie P.;Kolobaric, Antonija;Long, Armari;Mullett, Steven J.;Burns, Jennifer K.;Jenkins, Aaron K.;DePoy, Lauren;Wendell, Stacy G.;McClung, Colleen A.;Morrison, Kathleen E.;Jasarevic, Eldin
• 通讯作者: Jasarevic, Eldin