Reproductive Development from Gonads to Fetuses

从性腺到胎儿的生殖发育

• 批准号: 10163223
• 负责人: Kyle Edwin Orwig
• 金额: $ 16.33万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-09 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10163223
• 关键词: Fetus; gonad development; reproductive development

PROJECT SUMMARY/ABSTRACT Discoveries in reproductive biology have had a remarkable impact in science and medicine, leading to several Nobel prizes in Physiology or Medicine in the past decade. Despite these advances in science that were produced by experts in the reproductive biology, the number of reproductive science trainees is dwindling at an alarming rate. To help reverse this trend, we have established this T32 Training Program in Reproductive Development from Gonads to Fetuses (RDGF). The purpose of this program is to tap the large, diverse and highly qualified pipeline of graduate students (PhD or MD/PhD) and postdoctoral fellows (MD or PhD) that matriculate at the University of Pittsburgh each year and recruit them to pursue training and careers in the reproductive sciences. This training program will enhance the recruitment of reproductive biology researchers into the unique environment at Magee-Womens Research Institute where graduate students, postdoctoral fellows, medical residents, medical fellows and junior faculty (119 total trainees) work side by side in state of the art research facilities and experience on a daily basis how fundamental research discoveries impact reproductive medicine and patient care. The overarching objectives of the Program are to select and recruit the most qualified candidates (3 PhD students and 3 postdocs/year) into the reproductive sciences and pair them with well-funded, productive mentors who are committed to the training mission of the program and the University of Pittsburgh/Magee. The program will provide trainees with the education, resources and technical experience to conduct impactful science, while adhering to the principles of responsible conduct of research and scientific integrity. Rigorous oversight and progress review of Trainee/Mentor teams will ensure that trainees are fully immersed in all aspects of academic career development, including career development coursework, publications, grant submissions and attendance/presentation at local and national/international meetings. Research productivity milestones (e.g., publications, grants and awards) combined with connections made in the reproductive biology community at meetings will set the stage for advancement to the next stage of career development. Full immersion of trainees in all aspects of their academic endeavors will endow them with a sense of ownership of their research productivity and increase the likelihood that they will be retained long-term in reproductive science-related careers. Graduate students (PhD or MD/PhD) can remain in the training program for a maximum of five years and postdoctoral fellows can remain in the program for a maximum of three years. However, our program requires that all trainees write and submit and individual training grant application during their second year of training. This is a valuable skill for a career in science and the turnover as trainees transition from institutional to individual awards will help maximize the number of trainees and impact of the program. We anticipate training a total of 6 graduate students and 6 postdoctoral trainees during the five year award period.

项目摘要/摘要 生殖生物学的发现对科学和医学产生了显著的影响，导致了几个 过去十年的诺贝尔生理学或医学奖。尽管科学上取得了这些进步，但 由生殖生物学专家制作的生殖科学实习生人数正在以 惊人的速度。为了帮助扭转这一趋势，我们建立了T32生殖培训计划 从性腺发育到胎儿(RDGF)。该计划的目的是开发大型、多样化和 高素质的研究生(博士或医学博士/博士)和博士后研究员(医学博士或博士) 每年在匹兹堡大学录取，并招募他们在 生殖科学。这一培训方案将加强生殖生物学研究人员的招聘。 进入玛吉妇女研究所的独特环境，那里的研究生、博士后 研究员、住院医师、医务研究员和初级教员(共119名实习生)在州内并肩工作 艺术研究设施和日常体验基础研究发现如何影响 生殖医学和病人护理。该计划的首要目标是选拔和招募 最合格的候选人(3名博士生和3名博士后/年)进入生殖科学和配对 他们拥有资金充足、富有成效的导师，他们致力于该计划的培训任务和 匹兹堡大学/马吉分校。该计划将为学员提供教育、资源和技术 在坚持负责任的研究行为原则的同时，进行有影响力的科学的经验 和科学的正直。对学员/指导团队的严格监督和进度审查将确保 学员完全沉浸在学术职业发展的方方面面，包括职业发展。 课程、出版物、助学金申请以及在当地和国家/国际的出席/演示 开会。与联系相结合的研究生产力里程碑(例如，出版物、赠款和奖励) 生殖生物学界在会议上所做的工作将为进入下一阶段奠定基础 关于职业发展的。学员完全沉浸在学术努力的方方面面将赋予他们 对他们的研究生产力有主人翁意识，并增加他们被留住的可能性 长期从事与生殖科学相关的职业。研究生(博士或医学博士/博士)可以留在 培训计划最长为五年，博士后研究员可在该计划中保留一年 最多三年。然而，我们的计划要求所有受训人员写和提交并个别 他们在第二年的培训期间申请培训补助金。对于从事科学工作来说，这是一项宝贵的技能 随着学员从机构奖项向个人奖项过渡，人员流动将有助于最大限度地增加 培训对象和项目的影响。我们预计培养6名研究生和6名博士后 五年奖励期内的实习生。

项目成果

Transport and Permeation Properties of Dapivirine: Understanding Potential Drug-Drug Interactions.

• DOI: 10.3390/pharmaceutics14091948
• 发表时间: 2022-09-14
• 期刊: Pharmaceutics
• 影响因子: 5.4
• 作者: Zheng R;Valicherla GR;Zhang J;Nuttall J;Silvera P;Marshall LJ;Empey PE;Rohan LC
• 通讯作者: Rohan LC

Investigating the Contribution of Drug-Metabolizing Enzymes in Drug-Drug Interactions of Dapivirine and Miconazole.

研究药物代谢酶在dapivirine和Miconazole的药物相互作用中的贡献。

• DOI: 10.3390/pharmaceutics13122193
• 发表时间: 2021-12-18
• 期刊: Pharmaceutics
• 影响因子: 5.4
• 作者: Valicherla GR;Graebing P;Zhang J;Zheng R;Nuttall J;Silvera P;Rohan LC
• 通讯作者: Rohan LC

Intestinal microbial circadian rhythms drive sex differences in host immunity and metabolism.

• DOI: 10.1016/j.isci.2023.107999
• 发表时间: 2023-10-20
• 期刊: ISCIENCE
• 影响因子: 5.8
• 作者: Munyoki, Sarah K.;Goff, Julie P.;Kolobaric, Antonija;Long, Armari;Mullett, Steven J.;Burns, Jennifer K.;Jenkins, Aaron K.;DePoy, Lauren;Wendell, Stacy G.;McClung, Colleen A.;Morrison, Kathleen E.;Jasarevic, Eldin
• 通讯作者: Jasarevic, Eldin