Health outcomes and cognitive effects of marijuana use among persons living with HIV/AIDS

吸食大麻对艾滋病毒/艾滋病患者的健康结果和认知影响

• 批准号: 10165870
• 负责人: Robert L Cook
• 金额: $ 14.88万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10165870
• 关键词: AIDS/HIV problem; Address; Adult; Affect; African American; Alcohol or Other Drugs use; Antibodies; Anxiety; Blood specimen; COVID-19; COVID-19 pandemic; Caring; Chronic; Chronic Disease; Cognitive; Continuity of Patient Care; Data; Data Collection; Dimensions; Economics; Enrollment; Epidemic; Family; Florida; Future; Goals; HIV; HIV Infections; Health; Immune system; Immunoglobulin G; Immunoglobulin M; Incidence; Infection; Inflammation; Interview; Link; Location; Longitudinal cohort; Measures; Mental Depression; Mental Health; Methods; Minority; Occupational; Outcome; Parents; Participant; Persons; Population; Post-Traumatic Stress Disorders; Prevalence; Prevention program; Preventive Intervention; Procedures; Research; Sampling; Sampling Studies; Severities; Social isolation; Substance Use Disorder; Surveys; Testing; Therapeutic; Time; Viral; Viral Load result; Visit; Vulnerable Populations; care outcomes; cognitive function; cohort; comorbidity; coronavirus disease; experience; follow-up; intervention program; marijuana use; marijuana use disorder; parent grant; psychosocial; public health emergency; social; surveillance data; treatment program

Abstract Persons living with HIV (PLWH) are an especially vulnerable population in the COVID-19 pandemic given their compromised immune system and comorbidities (e.g., substance use, mental health issues). Currently, no research has examined how the broad impacts of COVID-19 (e.g., extended social isolation, anxiety, family loss) are affecting marijuana use, cannabis use disorder (CUD), and care engagement in PLWH. Further, research has not clarified whether chronic marijuana use will interact with HIV infection to impact the onset and progression of COVID-19 infection. This urgent supplement will allow us to capture this window of opportunity and collect timely data to address these gaps. Our ongoing R01 study of a PLWH cohort focusing on marijuana use provides many unique strengths to support this supplement. The primary goal of the active R01 project is to examine the long-term impact of marijuana use on cognitive functioning and health outcomes in a cohort of PLWH (currently 300 participants completed baseline assessment) in Florida. This supplement is within the scope of the parent grant but extends the parent study by incorporating COVID-19-related questions/measures into the ongoing data collection. We will collect additional data using a mixed method approach which includes quantitative survey questions and in-depth qualitative interviews on a selected subsample. We will conduct COVID-19 antibody tests using the blood sample we collect as a part of the parent grant procedures. We will also link the collected data with the Florida Department of Health EHARS data on HIV-related outcomes (e.g., viral load) over time, which is also a part of the parent study. The specific aims of this supplement include: 1) To identify the impact of the COVID-19 pandemic on changes in marijuana use and cannabis use disorder (CUD) among PLWH; 2) To determine the impact of the COVID-19 pandemic on the HIV care continuum (i.e., HIV care engagement) and outcomes (i.e., viral load); and 3) To estimate the prevalence of COVID-19 infection in our study sample after September 2020, using antibody testing for IgG and IgM. If we have a large enough sample (i.e., 10% tested positive for COVID-19), we will examine the association between marijuana use status and COVID-19 incidence/severity. This study will be the first to address the impacts of the COVID-19 pandemic among an ongoing cohort of PLWH with a focus on marijuana use and its related health outcomes. By collecting additional COVID-19-related information as a part of the regular follow-ups in the parent study, we will be able to provide valuable evidence on how the COVID-19 pandemic may cause changes in PLWH’s marijuana use/CUD and HIV care/outcomes and will be able to identify the underlying mechanism of these changes. Results from the antibody tests may also provide informative data on whether marijuana use interacts with HIV in affecting COVID-19 incidence and severity, which can potentially inform future prevention and treatment programs for COVID-19 in this population.

抽象的 鉴于他们 免疫系统和合并症受损（例如，药物使用，心理健康问题）。目前，没有 研究研究了Covid-19的广泛影响如何（例如，扩展的社会隔离，焦虑，家庭 损失）正在影响大麻的使用，大麻使用障碍（CUD）和PLWH的护理参与。更远， 研究尚未阐明长期使用大麻是否会与艾滋病毒感染相互作用，以影响发作和 共vid-19感染的进展。这种紧急补充剂将使我们能够捕获这个机会之窗 并收集及时的数据以解决这些差距。我们正在进行的R01 PLWH队列研究的研究 大麻的使用提供了许多独特的优势来支持这种补充。主动R01的主要目标 项目是要研究大麻使用对认知功能和健康结果的长期影响 佛罗里达州的PLWH队列（目前有300名参与者完成了基线评估）。这种补充是 在父授予的范围内，但通过纳入共同研究，扩展了父母的研究 问题/措施进入正在进行的数据收集中。我们将使用混合方法收集其他数据 方法包括定量调查问题和对选定的深入定性访谈 子样本。我们将使用我们收集的血液样本进行COVID-19抗体测试 家长赠款程序。我们还将将收集的数据与佛罗里达州卫生部Ehars联系起来 随着时间的推移，有关HIV相关结果（例如病毒负荷）的数据，这也是父母研究的一部分。具体 该补充的目的包括：1）确定COVID-19的影响对变化的变化 PLWH中的大麻使用和大麻使用障碍（CUD）； 2）确定COVID-19的影响 艾滋病毒护理连续体（即艾滋病毒护理参与）和结果（即病毒负荷）的大流行；和3）到 使用抗体估计我们研究样本中Covid-19感染的患病率 IgG和IgM的测试。如果我们有足够大的样本（即10％的Covid-19测试阳性），我们将 检查大麻使用状态与COVID-19事件/严重性之间的关联。这项研究将是 第一个解决了共同-19大流行在正在进行的PLWH中的影响的影响，重点是 大麻使用及其相关的健康结果。通过收集其他COVID-19的信息作为一个 父母研究中的一部分常规后续行动，我们将能够提供有关如何如何证明 COVID-19大流行可能会导致PLWH的大麻使用/CUD和HIV护理/成果的变化，并且将是 可以识别这些变化的基本机制。抗体测试的结果也可能提供 有关大麻使用是否与HIV相互作用在影响COVID-19事件和严重程度的信息， 这可能会为COVID-19的未来预防和治疗计划提供信息。

项目成果

Need to Improve Dose Measurements in Studies of Marijuana Use for Pain.

需要改进大麻止痛研究中的剂量测量。

• DOI: 10.1097/qai.0000000000002238
• 发表时间: 2020
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Sajdeya,Ruba;Cook,RobertL
• 通讯作者: Cook,RobertL

Change in marijuana use and its associated factors among persons living with HIV (PLWH) during the COVID-19 pandemic: Findings from a prospective cohort.

• DOI: 10.1016/j.drugalcdep.2021.108770
• 发表时间: 2021-08-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Wang Y;Ibañez GE;Vaddiparti K;Stetten NE;Sajdeya R;Porges EC;Cohen RA;Cook RL
• 通讯作者: Cook RL