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University of Iowa – 3T ESP MRI Scanner

爱荷华大学 — 3T ESP MRI 扫描仪

基本信息

批准号：
10170638
负责人：
VINCENT A MAGNOTTA
金额：
$ 195万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2023-11-30
项目状态：
已结题

项目摘要

The University of Iowa is requesting funds to acquire the GE Extreme Slewrate Performance (ESP) 3T head-only scanner. The ESP scanner provides high end gradient performance (Amplitude=115 mT/m and Slewrate=700T/m/s), which will offer significant improvements for diffusion imaging. The high slew rate performance provides a factor of two reduction in echo-spacing across all resolutions typically used for neuroimaging. Such capabilities will result in the ability to study tissue microstructure, which has been limited in the past by gradient performance. This gradient performance coupled with the MUSSELS based algorithms being developed in the Magnetic Resonance Research Facility (MRRF) will provide the ability to assess tissue microstructure at high resolution when using the high b-values needed to employ biophysical models to characterize tissue microstructure. The ESP scanner will also provide lower SAR that will enhance our T1ρ imaging efforts. In addition, the scanner provides a more friendly environment for research subjects. This scanner is needed to support the rapidly expanding neuroimaging community that was been brought about by the formation of the Iowa Neuroscience Institute (INI). The INI has hired ten faculty in the past three years that are using neuroimaging as part of their research program. We have outgrown the time available on our existing research 3T scanner and additional resources are needed to support these neuroimaging efforts. The MRRF serves as a Core University Facility and houses the only research dedicated scanning facilities in the State of Iowa. The proposed scanner would support 26 investigators with 33 NIH funded grants with an additional 15 pending NIH grants. The MRRF supports the research program of investigators from 6 colleges and 15 departments across campus. The facility also supports the research efforts from other state institutions (e.g. Iowa State University) as well as the Midwest. These investigators are a highly productive group, which study a variety of diseases including bipolar disorder, brain development, aging, neurodegenerative disorders, and cancer. The MRRF is an active research group who are undertaking the development of novel imaging sequences to support our large number of users. This includes novel imaging sequences to assess 1) tissue microstructure, 2) brain function, 3) cancer, and 4) metabolism. These projects would significantly benefit from the proposed scanner and provide future imaging capabilities for users of the facility. There is strong institution commitment for this equipment. The proposed ESP 3T scanner will be located in the $120 million Pappajohn Biomedical Discovery Building (PBDB) and the Iowa Institute for Biomedical Imaging (IIBI) was allocated 31,000 square feet of space in this building for human and animal imaging. To help support the scanner, the Department of Radiology and Biomedical Engineering have recently hired 3 additional faculty who are MR physicists. Finally, the Department of Radiology will cover the costs to install the ESP scanner and will provide financial support in case user fees are unable to cover expenses for the facility.

爱荷华州大学正在申请资金以收购GE Extreme Slewrate Performance（ESP）3 T 头部扫描仪ESP扫描仪提供高端梯度性能（振幅=115 mT/m，转换速率= 700 T/m/s），这将为扩散成像提供显著改进。高压摆率性能提供了在所有分辨率上回声间隔的两倍减小，神经成像这种能力将导致研究组织微观结构的能力，这在过去是有限的。过去的梯度性能。这种梯度性能加上基于MUSSELS的算法磁共振研究设施（MRRF）正在开发的一种新的磁共振成像技术将提供评估组织的能力，当使用生物物理模型所需的高b值来表征组织微观结构。ESP扫描仪还将提供更低的SAR，这将提高我们的T1ρ 图像的努力。此外，扫描仪为研究对象提供了更友好的环境。这需要扫描仪来支持迅速扩大的神经成像社区，成立了爱荷华州神经科学研究所。在过去的三年里，INI聘请了10名教师，正在使用神经成像作为他们研究计划的一部分。我们已经超过了现有的时间，研究3 T扫描仪和额外的资源，需要支持这些神经成像的努力。该MRRF作为一个核心的大学设施和房屋唯一的研究专用扫描设施在爱荷华州。拟议的扫描仪将支持26名研究人员，33名NIH资助的赠款，另外15个国家卫生研究院的赠款。MRRF支持来自6所大学的研究人员的研究计划和15个系的学生该设施还支持其他国家机构的研究工作 (e.g.爱荷华州州立大学）以及中西部。这些调查人员是一个富有成效的群体，研究各种疾病，包括双相情感障碍，大脑发育，衰老，神经退行性疾病，和癌症MRRF是一个活跃的研究小组，正在开发新的成像技术支持我们的大量用户。这包括新的成像序列，以评估1）组织微观结构，2）脑功能，3）癌症和4）代谢。这些项目将大大受益于拟议的扫描仪，并提供未来的成像能力，为用户的设施。对这种设备有强有力的机构承诺。建议的ESP 3 T扫描仪将位于耗资1.2亿美元的帕帕约翰生物医学发现大楼（PBDB）和爱荷华州生物医学研究所成像（IIBI）在这座建筑中分配了31,000平方英尺的空间用于人类和动物成像。到为了帮助支持扫描仪，放射学和生物医学工程系最近聘请了3名更多的教师是MR物理学家。最后，放射科将支付安装 ESP扫描仪，并将提供财政支持的情况下，用户的费用是无法支付的设施。