Core D: Neurocircuitry and Behavior Core

核心 D：神经回路和行为核心

• 批准号: 10238634
• 负责人: VINCENT A MAGNOTTA
• 金额: $ 23.76万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-16 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10238634
• 关键词: Address; Adult; Age; Animal Model; Animals; Behavior; Behavioral; Behavioral Assay; Bioinformatics; Brain; Brain imaging; Child; Clinic; Clinical; Clinical Research; Clinical Trials; Cognition; Cognitive; Collaborations; Communities; Conceptions; Country; Data; Data Set; Development; Diagnosis; Elderly; Ensure; Equipment; Experimental Designs; Family; Fostering; Funding; Hawks; Human; Image; Image Analysis; Imaging Device; Imaging Techniques; Individual; Institutes; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Investigation; Iowa; Knowledge; Laboratories; Laboratory Finding; Laboratory Personnel; Learning; Longevity; Manuals; Memory; Metabolism; Modality; Monitor; Neurosciences; Physiologic pulse; Prevention; Process; Protocols documentation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rural Population; Scientist; Services; Sleep; Social Interaction; Specific qualifier value; Structure; System; Technology; Training; Transcranial magnetic stimulation; Translating; Translations; Universities; analysis pipeline; bioimaging; cognitive change; cost effectiveness; data management; design; disability; experimental study; flexibility; human model; laboratory experience; neonate; neural circuit; neuroimaging; novel; programs; quality assurance; research study; rural area; service utilization; tool; translational approach

PROJECT SUMMARY: NEUROCIRCUITRY AND BEHAVIOR CORE (NBC) The primary objective of the Neurocircuitry and Behavior Core (NBC) is to provide state-of-the-art services that foster studies of intellectual and developmental disability (IDD) across the lifespan—from conception to adulthood, tailored to a rural population. The Core will support research projects affiliated with the Hawk- IDDRC that utilize both animals and humans as well as those that cross-fertilize a translational approach to the study of IDD from a lifespan perspective. The Core is made up of two units: 1) Neuroimaging Division (NID) and 2) Neural Circuits and Behavior Division (NCBD). The NID will assist in the development, implementation, and completion of neuroimaging research studies in animal models as well as humans. Neuroimaging modalities will focus on imaging techniques to assess brain structure, function, and metabolism. The resources provided will include expertise in the following aspects of brain imaging: a) development of novel imaging tools, pulse sequences, and equipment; b) implementation of protocols for image acquisition; c) implementation and deployment of standard image analysis pipelines; d) development of novel image analysis strategies; and e) data management, bioinformatics, and statistical support for imaging data. The NCBD will provide expertise in neural circuit function, behavior (e.g. social interaction, sleep), and cognition (e.g. learning and memory) in animal models and humans using tools that are often not available within individual laboratories. For studies using animal models, the NCBD will provide facilities and services to aid investigators performing behavioral assays. For human studies, the NCBD has significant expertise in studying human behavior and cognition across the lifespan and will design and implement cognitive paradigms to study neural circuits, which can be applied to individuals with intellectual and developmental disabilities as well as controls. Finally, the NID and NCBD are able to conduct experiments as requested by investigators, or will provide the necessary training to enable laboratory personnel to perform experiments in the facility. The NBC will integrate and capitalize upon strong existing resources currently available at the University of Iowa including the Iowa Institute for Biomedical Imaging (IIBI) and the Iowa Neuroscience Institute (INI). Tools that are developed as part of the NBC will be shared with IDD investigators across the country. The NBC will support 27 federally funded projects ($11.3 million per year) and will build upon strong existing collaborations between basic scientists who use animal models and clinical scientists engaged in human brain studies. In addition, the NBC will help strengthen the relationship between scientists and the IDD community and their families, many of whom live in rural areas, helping foster collaborations that will enable a better understanding of IDD from a lifespan perspective.

项目摘要：神经记录和行为核心（NBC） 神经记录和行为核心（NBC）的主要目标是提供最先进的服务 从概念到整个生命周期的智力和发育障碍（IDD）的培养研究 成年，量身定制的人口粗糙。核心将支持鹰的研究项目分支机构 利用动物和人类的IDDRC以及交叉施用的动物的IDDRC 从寿命的角度研究IDD。核心由两个单元组成：1）神经影像学部（NID） 2）神经回路和行为部（NCBD）。 NID将协助开发， 在动物模型和人类中的神经影像学研究的实施和完成。 神经影像的方式将集中在评估大脑结构，功能和代谢的成像技术上。 所提供的资源将包括大脑成像以下各个方面的专业知识：a）开发 新颖的成像工具，脉冲序列和设备； b）实施图像采集协议； c） 标准图像分析管道的实施和部署； d）开发新型图像分析 策略； E）数据管理，生物信息学和成像数据的统计支持。 NCBD会 提供神经电路功能，行为（例如社交互动，睡眠）和认知方面的专业知识（例如学习 在动物模型和人类中使用的记忆）使用个人通常不可用的工具 实验室。对于使用动物模型的研究，NCBD将提供设施和服务以帮助调查人员 执行行为测定。对于人类研究，NCBD在研究人类方面具有重要的专业知识 整个生命周期的行为和认知，将设计和实施认知范式来研究中立 电路，可以应用于智力和发育障碍的人以及控制。 最后，NID和NCBD能够根据调查人员的要求进行实验，或者将提供 必要的培训使实验室人员能够在设施中进行实验。 NBC将集成并利用该大学目前可用的强大现有资源 爱荷华州包括爱荷华州生物医学成像研究所（IIBI）和爱荷华州神经科学研究所（INI）。工具 作为NBC的一部分开发的将与全国各地的IDD调查人员共享。 NBC会 支持27个由联邦资助的项目（每年1,130万美元），并将基于强大的现有合作 在使用动物模型的基本科学家和从事人脑研究的临床科学家之间。在 此外，NBC将有助于加强科学家与IDD社区之间的关系 家庭，其中许多人住在农村地区 从寿命的角度来看。