Characterization and Enhancement of Functional T1rho Imaging

功能性 T1rho 成像的表征和增强

• 批准号: 9925775
• 负责人: VINCENT A MAGNOTTA
• 金额: $ 34.31万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925775
• 关键词: Activities of Daily Living; Address; Adopted; Amides; Animal Model; Animals; Biochemical Process; Biology; Biosensor; Bipolar Disorder; Blood Vessels; Brain; Brain Mapping; Brain imaging; Brain region; Characteristics; Chemicals; Data; Development; Disease; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Glucose; Glutamates; Human; Image; Image Enhancement; Imaging Techniques; Impairment; Implant; Knowledge; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Mental disorders; Metabolism; Methods; Motion; Motor Cortex; Mus; Noise; Panic Disorder; Physiologic pulse; Preparation; Process; Protons; Receiver Operating Characteristics; Relaxation; Reproducibility; Sampling; Signal Transduction; Source; Spin Labels; Techniques; Testing; Time; Tissues; Venous; Visual; Visual Cortex; Water; Work; base; blood oxygen level dependent; experience; hemodynamics; hydroxyl group; imaging study; improved; innovation; insight; macromolecule; nervous system disorder; novel; novel imaging technique; patient population; relating to nervous system; response; temporal measurement

PROJECT SUMMARY/ABSTRACT Recent work suggests that functional T1ρ provides a novel imaging technique to study brain function. This signal has been to exist in human and animal studies of the visual cortex. This technique has been shown to be separate from the hemodynamic response typically used to assess brain function using MR imaging. Initial work has shown that this signal responds faster than arterial and venous vascular signals measured using ASL and BOLD imaging respectively. In addition, the T1ρ signal has been shown to be sensitive to metabolism (glucose, glutamate, and pH) as well as neural currents. Finally, we have shown that the functional T1ρ signal was sensitive to changes in panic disorder not evident using BOLD imaging as well as shows a decoupling from the BOLD signal in bipolar disorder. These findings highlight the unique capabilities of this new functional imaging technique, which may provide new insight into psychiatric and neurological disorders. However, a number of gaps exist in our current understanding of the functional T1ρ signal, which this proposal aims to address. The aims of this project include: 1) Determine the relationship between functional T1ρ responses and local metabolites and neural currents using implanted biosensors in animal models; 2) Enhance spatial coverage and temporal sampling of functional T1ρ imaging using multi-band and compressed-sensing; 3) Determine the temporal and spatial response functions of T1ρ relative to BOLD and ASL; and 4) Evaluate the stability, reliability, and accuracy of functional T1ρ mapping. As part of these specific aims, we will evaluate techniques to eliminate the intravascular signal from the measurements and define a canonical impulse response function that can be used in the analysis of future functional T1ρ imaging studies. Finally, the reliability analysis proposed in Aim 4 will determine the ability of functional T1ρ mapping to be adopted by other groups and extend the technique to paradigms outside of the visual cortex. The proposed study will allow us to interpret the functional changes between patient populations by understanding the source of the functional T1ρ signal. The understanding of the signal source will also highlight many other psychiatric and neurological disorders where this functional imaging technique can be applied.

项目摘要/摘要 最近的工作表明，功能性T1ρ提供了研究大脑功能的新型成像技术。这 信号已经存在于视觉皮层的人类和动物研究中。该技术已被证明 与通常用于使用MR成像评估大脑功能的血液动力学反应分开。最初的 工作表明，该信号响应比使用ASL测量的动脉和静脉血管信号更快 和大胆的成像。另外，T1ρ信号已被证明对代谢很敏感 （葡萄糖，谷氨酸和pH）以及神经电流。最后，我们已经证明了功能性T1ρ信号 对恐慌症的变化敏感，而不是使用粗体成像的证据，并显示出脱钩 来自双相情感障碍的大胆信号。这些发现突出了这个新功能的独特功能 成像技术，这可能为精神病和神经系统疾病提供新的见解。但是， 我们目前对功能性T1ρ信号的理解中存在差距数量，该提案的目的是 地址。该项目的目的包括：1）确定功能性T1ρ响应与 在动物模型中使用植入生物传感器的局部代谢产物和神经流； 2）增强空间 使用多波段和压缩感应的功能T1ρ成像的覆盖范围和临时抽样； 3） 确定T1ρ相对于BOLD和ASL的暂时和空间响应函数； 4）评估 功能性T1ρ映射的稳定性，可靠性和准确性。作为这些特定目标的一部分，我们将评估 从测量结果中消除血管内信号并定义规范冲动的技术 可以用于分析未来功能T1ρ成像研究的响应函数。最后， AIM 4中提出的可靠性分析将决定功能性T1ρ映射的能力 其他组并将技术扩展到视觉皮层之外的范例。拟议的研究将允许 我们通过了解患者人群之间的功能变化来理解 功能性T1ρ信号。对信号源的理解还将突出许多其他精神病学和 可以应用这种功能成像技术的神经疾病。