权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Exercise Intervention for Slowing HD Progression

运动干预可减缓 HD 进展

基本信息

批准号：
9149031
负责人：
VINCENT A MAGNOTTA
金额：
$ 19.06万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-30 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9149031
关键词：
Accounting Adenine Aerobic Affect Age Age of Onset Area Atrophic Basal Ganglia Blood Vessels Body Weight decreased Brain Brain imaging Brain-Derived Neurotrophic Factor Cerebrum Cognitive Corpus striatum structure Creatine Cytosine Data Diagnosis Diffusion Diffusion Magnetic Resonance Imaging Disease Progression Dose Eating Energy Supply Enzymes Equilibrium Event Exercise Genes Glucose Goals Growth Guanine Health Home environment Huntington Disease Huntington gene Image Individual Intervention Intervention Studies Iowa Lead Learning Length Literature Magnetic Resonance Imaging Measures Metabolic Metabolic Marker Metabolism Moderate Exercise Motor Neurodegenerative Disorders Neurons Nutrient Onset of illness Performance Physical Exercise Physical activity Positioning Attribute Production Randomized Controlled Trials Relaxation Rest Strenuous Exercise Symptoms Testing Therapeutic Effect Time Triad Acrylic Resin Universities VO2max Walking Work base brain health exercise intensity exercise intervention exercise program fitness glucose metabolism improved in vivo insight lifestyle factors mitochondrial dysfunction motor impairment motor symptom public health relevance putamen randomized trial symptom treatment treatment response vigorous intensity white matter

项目摘要

DESCRIPTION (provided by applicant): Recent work suggests that exercise that moderate-to-vigorous intensity physical exercise is associated with slowing of symptom progression (motor, cognitive, and psychiatric) in prodromal Huntington's Disease (HD). In addition, the literature shows that the intervention is well tolerated in prodromal HD. In subjects without HD, moderate intensity physical exercise has been shown to improve white matter integrity, increase caudate neuronal activity, and increase striatum activation in spatial learning. Exercise has been shown to increase metabolic enzymes, promote growth of blood vessels to provide increased nutrient and energy supply, increase central BDNF expression, and to promote local glucose metabolism in the basal ganglia. We hypothesize that initiating a moderate intensity physical exercise program will substantially slow progressive striatal volume loss and improve connectivity in prodromal HD. To test this hypothesis, we will undertake a six- month randomized controlled study of home-based moderate intensity aerobic walking exercise program or balance and toning control. In the proposed study, MR will be used to assess the impact of fitness and an exercise intervention on well established markers for HD progression in the brain including: volume of the caudate and putamen and white matter integrity using diffusion weighted imaging. In addition, we will employ a quantitative relaxation parameter, T1 relaxation in the rotating frame (T1ρ), which we have shown to be sensitive to prodromal HD progression. To evaluate the influence of fitness and therapeutic effect of moderate intensity exercise in prodromal HD, we propose two specific aims: 1) Does baseline fitness account for variance in motor function and brain imaging measures in prodromal HD? and 2) Does a moderate-to-vigorous exercise intervention influence the progression of motor impairment and brain degeneration in prodromal HD? This study will provide insight into the cascade of events that lead to anatomical changes in prodromal HD and will help reveal how exercise improves motor, cognitive, and psychiatric health in subjects with the Htt gene expansion.