Scripps Translational Science Institute

斯克里普斯转化科学研究所

• 批准号: 10173181
• 负责人: Eric Jeffrey Topol
• 金额: $ 9.78万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10173181
• 关键词: Autopsy; Bachelor' s Degree; Big Data Methods; Bioinformatics; Biological Sciences; California; Child; Childhood; Clinical Trials; Collaborations; Communities; Complement; County; Development; Disease; Enrollment; Flowers; Future; Genomic medicine; Genomics; Goals; Grant; Growth; Health; Individual; Infrastructure; Institutes; Longevity; Medical Research; Medicine; Molecular; Participant; Pathogen detection; Pharmaceutical Preparations; Population; Precision Medicine Initiative; Research; Research Institute; Technology; Training; Translational Research; Underrepresented Minority; United States National Institutes of Health; clinical care; cohort; college; digital; fitbit; handheld mobile device; healthy aging; human genomics; improved; individualized medicine; industry partner; innovation; mobile application; precision medicine; programs; sensor; supercomputer; undergraduate student

Overall Abstract The Scripps Translational Science Institute (STSI) is the center of the Scripps Hub, formed in 2007, dedicated to accelerating individualized medicine, improving medical research and clinical care, and training the future leaders of the biomedical workforce. The Scripps hub has included The Scripps Research Institute (TSRI) and Scripps Health (SH) as its principal components, along with the San Diego Supercomputer Center for its bioinformatic initiatives. In the new CTSA cycle, our partners have expanded to now include the California Institute for Medical Research (Calibr), recently made a Scripps Research Institute, and the Rady Children's Institute of Genomic Medicine (RCIGM). These 2 new partners will markedly increase our efforts for drug repurposing/ discovery and across the lifespan to the pediatric population. Digital medicine has been one of STSI's core strengths, with innovations to digitize clinical trials from end-to-end (enrollment to dissemination). Our focus on human genomics has been critical to building infrastructure at the hub, supporting many studies throughout the San Diego region including healthy aging (Wellderly), unknown diseases, molecular autopsy and rapid pathogen detection through sequencing. We received support from the CTSA Trial Innovation Network (TIN) for 2 of these projects. Recent STSI-supported projects feature a fusion of both genomics and digital medicine for mobile app development and clinical trials. An important affirmation of STSI's progress and contributions was its selection in 2016 by the NIH to be The Participant Center for the Precision Medicine Initiative (PMI) All of Us cohort. Many other aspects of the Scripps hub are undergoing remarkable growth. Our life science industry partners, which has been an essential STSI strategy, has expanded with more than 20 new collaborations over the past CTSA cycle. A few of these have led to exclusive big data analytic programs, cumulatively, with Walgreens, Withings, and Fitbit, involving tens of millions of individuals using mobile device sensors. Community engagement research at the Scripps hub has blossomed with 3 new R01 grants that build on our track record of working with underrepresented minorities in San Diego County and expertise in digital medicine technology. Our inter-hub collaborations and active participation in the CTSA Consortium have markedly increased, as have our educational and training initiatives. We have developed new initiatives to further enhance workforce diversity and entrepreneurial training. These efforts are newly complemented by the Scripps Research Biosciences College that will begin enrolling undergraduate students for a baccalaureate degree next year.

总括 摘要 斯克里普斯翻译科学研究所(STSI)是斯克里普斯中心的中心，成立于2007年，致力于 为加快个体化医疗，改善医学研究和临床护理，培养未来 生物医学劳动力的领导者。斯克里普斯中心包括斯克里普斯研究所(TSRI)和 Scripps Health(SH)作为其主要组成部分，以及圣地亚哥超级计算机中心的 生物信息学倡议。在新的CTSA周期中，我们的合作伙伴已经扩大到现在包括加利福尼亚州 医学研究所(CALIBR)，最近成立了斯克里普斯研究所，以及拉迪儿童研究所 基因组医学研究所(RCIGM)。这两个新的合作伙伴将显著增加我们在毒品方面的努力 重新调整用途/发现，并跨越儿童人口的生命周期。数字医疗已经成为 STSI的核心优势，从端到端(登记到传播)的临床试验数字化创新。 我们对人类基因组学的关注对于建立枢纽的基础设施至关重要，支持了许多研究 整个圣地亚哥地区包括健康老龄化(韦尔德利)，未知疾病，分子尸检 以及通过测序快速检测病原体。我们得到了CTSA试验创新网络的支持 (锡)用于其中两个项目。最近由STSI支持的项目融合了基因组学和数字技术 用于移动应用程序开发和临床试验的医药。对STSI进步的重要肯定和 其贡献是在2016年被美国国立卫生研究院选为精准医学参与中心 主动权(PMI)我们所有人都是。 斯克里普斯枢纽的许多其他方面正在经历显着的增长。我们的生命科学行业合作伙伴， 这一直是STSI的一项基本战略，在过去的20多次新合作中得到了扩展 CTSA循环。其中一些已经导致了独家大数据分析程序，累积起来，与沃尔格林， Withing和Fitbit，涉及数千万使用移动设备传感器的个人。社区 斯克里普斯中心的参与度研究蓬勃发展，根据我们的记录获得了3项新的R01奖励 与圣地亚哥县未被充分代表的少数族裔合作，以及在数字医疗技术方面的专业知识。 我们在中心之间的合作和对CTSA联盟的积极参与显著增加， 我们的教育和培训举措。我们已制订新措施，进一步提升劳动人口。 多元化和创业培训。这些努力最近得到了斯克里普斯研究中心的补充 生物科学学院将于明年开始招收本科生攻读学士学位。