Scripps Translational Science Institute

斯克里普斯转化科学研究所

• 批准号: 10401476
• 负责人: Eric Jeffrey Topol
• 金额: $ 575.94万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10401476
• 关键词: Alaska Native; Autopsy; Bachelor' s Degree; Back; Behavioral Sciences; Big Data; Big Data Methods; Bioethics; Bioinformatics; Biological Sciences; Biomedical Research; California; Caring; Child; Childhood; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Health Aides; Competence; Complement; Computational Biology; Consultations; County; Data; Data Analytics; Development; Disease; Electronic Health Record; Enrollment; Environment; Faculty; Federally Qualified Health Center; Flowers; Future; Genetic; Genomic medicine; Genomics; Goals; Grant; Growth; Health; Healthcare; Human; Individual; Industry; Informatics; Informed Consent; Infrastructure; Institutes; Institution; Internships; Lead; Life; Longevity; Medical; Medical Research; Medicine; Molecular; Pacific Islands; Participant; Pathogen detection; Pathway interactions; Patient Care; Patients; Persons; Phase; Physicians; Play; Population; Positioning Attribute; Precision Medicine Initiative; Privacy; Research; Research Institute; Research Methodology; Resolution; Resource Informatics; Resources; Role; Schools; Science; Scientist; Security; Services; Students; TNFSF15 gene; Technology; Therapeutic Intervention; Training; Training Programs; Training Support; Translational Research; Trust; Underrepresented Minority; United States National Institutes of Health; Universities; clinical care; clinical practice; cohort; collaborative environment; college; community engagement; community partnership; data exchange; design; digital; digital medicine; drug repurposing; electronic data; fitbit; handheld mobile device; health care delivery; health data; healthy aging; human genomics; improved; individualized medicine; industry partner; innovation; mobile application; patient engagement; precision medicine; programs; racial and ethnic; racial diversity; recruit; sensor; socioeconomics; supercomputer; supportive environment; tool; translational scientist; tribal health; undergraduate student; wearable sensor technology; wireless sensor

The Scripps Translational Science Institute (STSI) is the center of the Scripps Hub, formed in 2007, dedicated to accelerating individualized medicine, improving medical research and clinical care, and training the future leaders of the biomedical workforce. The Scripps hub has included The Scripps Research Institute (TSRI) and Scripps Health (SH) as its principal components, along with the San Diego Supercomputer Center for its bioinformatic initiatives. In the new CTSA cycle, our partners have expanded to now include the California Institute for Medical Research (Calibr), recently made a Scripps Research Institute, and the Rady Children's Institute of Genomic Medicine (RCIGM). These 2 new partners will markedly increase our efforts for drug repurposing/ discovery and across the lifespan to the pediatric population. Digital medicine has been one of STSI's core strengths, with innovations to digitize clinical trials from end-to- end (enrollment to dissemination). Our focus on human genomics has been critical to building infrastructure at the hub, supporting many studies throughout the San Diego region including healthy aging (Wellderly), unknown diseases, molecular autopsy and rapid pathogen detection through sequencing. We received support from the CTSA Trial Innovation Network (TIN) for 2 of these projects. Recent STSI-supported projects feature a fusion of both genomics and digital medicine for mobile app development and clinical trials. An important affirmation of STSI's progress and contributions was its selection in 2016 by the NIH to be The Participant Center for the Precision Medicine Initiative (PMI) All of Us cohort. Many other aspects of the Scripps hub are undergoing remarkable growth. Our life science industry partners, which has been an essential STSI strategy, has expanded with more than 20 new collaborations over the past CTSA cycle. A few of these have led to exclusive big data analytic programs, cumulatively, with Walgreens, Withings, and Fitbit, involving tens of millions of individuals using mobile device sensors. Community engagement research at the Scripps hub has blossomed with 3 new RO1 grants that build on our track record of working with underrepresented minorities in San Diego County and expertise in digital medicine technology. Our inter-hub collaborations and active participation in the CTSA Consortium have markedly increased, as have our educational and training initiatives. We have developed new initiatives to further enhance workforce diversity and entrepreneurial training. These efforts are newly complemented by the Scripps Research Biosciences College that will begin enrolling undergraduate students for a baccalaureate degree next year.

斯克里普斯翻译科学研究所(STSI)是斯克里普斯中心的中心，成立于2007年，致力于 加快个体化医疗，提高医学研究和临床护理水平，培养未来的领导者 生物医学工作人员。斯克里普斯中心包括斯克里普斯研究所(TSRI)和斯克里普斯健康(SH)，作为 它的主要组成部分，以及圣地亚哥超级计算机中心的生物信息学倡议。在新的 CTSA周期，我们的合作伙伴已经扩大到现在包括加州医学研究所(CALIBR)，最近 建立了斯克里普斯研究所和拉迪儿童基因组医学研究所(RCIGM)。这两个新的 合作伙伴将显著增加我们在药物重新用途/发现方面的努力，并在整个生命周期内为儿科 人口。数字医学一直是STSI的核心优势之一，其创新之处在于将临床试验从端到端数字化 结束(注册到分发)。我们对人类基因组学的关注对于在枢纽建设基础设施至关重要， 支持圣地亚哥地区的许多研究，包括健康老龄化(韦尔德利)，未知疾病， 分子尸检和通过测序快速检测病原体。我们从CTSA试验中得到了支持 其中两个项目的创新网络(TIN)。最近由STSI支持的项目融合了基因组学和 用于移动应用程序开发和临床试验的数字医疗。对STSI进步的重要肯定和 它的贡献是在2016年被美国国立卫生研究院选为精密医学倡议的参与中心 (PMI)我们所有人都是同龄人。 斯克里普斯枢纽的许多其他方面正在经历显着的增长。我们的生命科学行业合作伙伴，它已经 是一项基本的STSI战略，在过去的CTSA周期中扩大了20多个新的合作项目。几个 这些导致了与Walgreens、Withing和Fitbit累积的独家大数据分析计划，涉及数十个 数以百万计使用移动设备传感器的个人。斯克里普斯中心的社区参与研究已经 随着3笔新的RO1赠款蓬勃发展，这些赠款建立在我们在旧金山与代表不足的少数族裔合作的记录基础上 迭戈县和数字医疗技术方面的专业知识。我们的中心之间的协作和积极参与 CTSA联盟显著增加，我们的教育和培训倡议也是如此。我们开发了新的 进一步加强劳动力多样性和创业培训的举措。这些努力得到了新的补充 斯克里普斯研究生物科学学院将于明年开始招收本科生攻读学士学位 年。