Scripps Clinical and Translational Science Hub

斯克里普斯临床和转化科学中心

• 批准号: 10621679
• 负责人: Eric Jeffrey Topol
• 金额: $ 602.98万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2030-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621679
• 关键词: 2019-nCoV; Acceleration; Address; Area; Artificial Intelligence; Awareness; Biosensor; California; Child; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Country; County; Data; Data Aggregation; Data Set; Dedications; Democracy; Diagnostic; Dimensions; Dissemination and Implementation; Diverse Workforce; Drug Screening; Ecosystem; Education; Elements; Ethics; Ethnic Origin; Fostering; Foundations; Genomic medicine; Genomics; Geography; Goals; Health; Healthcare; Heart Rate; Human; Human Resources; Industry Collaboration; Informatics; Institute of Medicine (U.S.); Institution; Intervention; Longevity; Medical; Medical Research; Methodology; Modeling; Outcome; Patients; Physiological; Population; Post-Acute Sequelae of SARS-CoV-2 Infection; Preventive; Process; Productivity; Program Development; Public Health; Public Health Informatics; Race; Research; Research Institute; Research Project Grants; Resource Informatics; Resources; Rest; SARS-CoV-2 infection; Sampling; Science; Services; Site; Sleep Disorders; Structure; Techniques; Time; Training; Translational Research; Universities; Vision; Voice; biomedical informatics; career development; community engaged research; community engagement; computer science; computerized data processing; cost effective; data standards; digital; digital medicine; digital models; digital platform; digital twin; diversity and inclusion; drug repurposing; educational atmosphere; empowerment; equity, diversity, and inclusion; ethnic diversity; health data; health equity; health inequalities; improved; individualized medicine; innovation; interoperability; multimodal data; multimodality; pandemic disease; pregnancy disorder; programs; public health emergency; racial diversity; real time model; response; secondary analysis; sensor; socioeconomics; tool; translational approach

PROJECT SUMMARY / ABSTRACT The Scripps Research Translational Institute (SRTI) is the foundation for the Scripps hub and is dedicated to accelerating science that will improve human health. SRTI’s emphasis on genomics, digital medicine, and informatics/analytics fosters a multi-dimensional understanding of individualized human health. The Scripps hub has previously included the Scripps Research Institute (SR) and Scripps Health (SH) as principal partners, including Rady Children’s Institute of Genomic Medicine (RCIGM) for genomic medicine initiatives and California Institute for Medical Research (Calibr) for drug repurposing / discovery. In the new CTSA cycle, our partners have expanded to include San Diego State University (SDSU), enabling us to combine forces in computer science, artificial intelligence, biosensors, and diversity inclusion and equity initatives. SRTI’s expertise in genomics was highlighted during the pandemic. We became one of the country’s most productive sequencing centers for SARS-CoV-2 by rapidly forming the “SEARCH” alliance to process samples with the San Diego County Department of Health, UCSD, Sharp Health, California Department of Public Health, Helix, and our partners RCIGM and SH. Digital medicine has been one of SRTI’s core strengths, having pioneered the first remote, site-less digital clinical trial and now expanding this methodology to address many other medical conditions such as health during pregnancy and sleep disorders. Our Digital Trials Center launched the Digital Engagement & Tracking for Early Control and Treatment Scripps (DETECT) study, and in a matter of weeks our team was able to accurately predict the likelihood of Covid with SARS-CoV-2 using passively collected resting heart rate data from wristband sensors and later to identify a physiologic signature that correlates with Long Covid (Post-Acute Sequelae or SARS-CoV-2 Infection). The Scripps hub will innovate clinical and translational science to improve human health across the lifespan and diverse racial, ethnic, geographic and socioeconomic communities. The hub will provide a nurturing environment for education, training, and career development with a focus on individualized health domains of genomics, digital medicine, and biomedical informatics, to empower tomorrow’s diverse workforce.

项目摘要/摘要