Scripps Clinical and Translational Science Hub

斯克里普斯临床和转化科学中心

• 批准号: 10621679
• 负责人: Eric Jeffrey Topol
• 金额: $ 602.98万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2030-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621679
• 关键词: 2019-nCoV; Acceleration; Address; Area; Artificial Intelligence; Awareness; Biosensor; California; Child; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Country; County; Data; Data Aggregation; Data Set; Dedications; Democracy; Diagnostic; Dimensions; Dissemination and Implementation; Diverse Workforce; Drug Screening; Ecosystem; Education; Elements; Ethics; Ethnic Origin; Fostering; Foundations; Genomic medicine; Genomics; Geography; Goals; Health; Healthcare; Heart Rate; Human; Human Resources; Industry Collaboration; Informatics; Institute of Medicine (U.S.); Institution; Intervention; Longevity; Medical; Medical Research; Methodology; Modeling; Outcome; Patients; Physiological; Population; Post-Acute Sequelae of SARS-CoV-2 Infection; Preventive; Process; Productivity; Program Development; Public Health; Public Health Informatics; Race; Research; Research Institute; Research Project Grants; Resource Informatics; Resources; Rest; SARS-CoV-2 infection; Sampling; Science; Services; Site; Sleep Disorders; Structure; Techniques; Time; Training; Translational Research; Universities; Vision; Voice; biomedical informatics; career development; community engaged research; community engagement; computer science; computerized data processing; cost effective; data standards; digital; digital medicine; digital models; digital platform; digital twin; diversity and inclusion; drug repurposing; educational atmosphere; empowerment; equity, diversity, and inclusion; ethnic diversity; health data; health equity; health inequalities; improved; individualized medicine; innovation; interoperability; multimodal data; multimodality; pandemic disease; pregnancy disorder; programs; public health emergency; racial diversity; real time model; response; secondary analysis; sensor; socioeconomics; tool; translational approach

PROJECT SUMMARY / ABSTRACT The Scripps Research Translational Institute (SRTI) is the foundation for the Scripps hub and is dedicated to accelerating science that will improve human health. SRTI’s emphasis on genomics, digital medicine, and informatics/analytics fosters a multi-dimensional understanding of individualized human health. The Scripps hub has previously included the Scripps Research Institute (SR) and Scripps Health (SH) as principal partners, including Rady Children’s Institute of Genomic Medicine (RCIGM) for genomic medicine initiatives and California Institute for Medical Research (Calibr) for drug repurposing / discovery. In the new CTSA cycle, our partners have expanded to include San Diego State University (SDSU), enabling us to combine forces in computer science, artificial intelligence, biosensors, and diversity inclusion and equity initatives. SRTI’s expertise in genomics was highlighted during the pandemic. We became one of the country’s most productive sequencing centers for SARS-CoV-2 by rapidly forming the “SEARCH” alliance to process samples with the San Diego County Department of Health, UCSD, Sharp Health, California Department of Public Health, Helix, and our partners RCIGM and SH. Digital medicine has been one of SRTI’s core strengths, having pioneered the first remote, site-less digital clinical trial and now expanding this methodology to address many other medical conditions such as health during pregnancy and sleep disorders. Our Digital Trials Center launched the Digital Engagement & Tracking for Early Control and Treatment Scripps (DETECT) study, and in a matter of weeks our team was able to accurately predict the likelihood of Covid with SARS-CoV-2 using passively collected resting heart rate data from wristband sensors and later to identify a physiologic signature that correlates with Long Covid (Post-Acute Sequelae or SARS-CoV-2 Infection). The Scripps hub will innovate clinical and translational science to improve human health across the lifespan and diverse racial, ethnic, geographic and socioeconomic communities. The hub will provide a nurturing environment for education, training, and career development with a focus on individualized health domains of genomics, digital medicine, and biomedical informatics, to empower tomorrow’s diverse workforce.

项目摘要/摘要 斯克里普斯翻译研究所(SRTI)是斯克里普斯中心的基础，致力于 加速将改善人类健康的科学。SRTI对基因组学、数字医学和 信息学/分析促进了对个性化人类健康的多维理解。斯克里普斯枢纽 之前包括斯克里普斯研究院(SR)和斯克里普斯健康公司(SH)作为主要合作伙伴， 包括拉迪儿童基因组医学研究所(RCIGM)的基因组医学倡议和加利福尼亚州 药物再利用/发现医学研究所(CALIBR)。在新的CTSA周期中，我们的合作伙伴 已经扩展到包括圣地亚哥州立大学(SDSU)，使我们能够在计算机中联合力量 科学、人工智能、生物传感器、多样性包容和公平倡议。 在大流行期间，SRTI在基因组学方面的专业知识得到了强调。我们成了这个国家最大的 SARS-CoV-2的高效测序中心--通过快速组建“搜索”联盟来处理样本 与圣地亚哥县卫生局、加州大学圣地亚哥分校、夏普卫生局、加州公共卫生部、 Helix，以及我们的合作伙伴RCIGM和SH。 数字医疗一直是SRTI的核心优势之一，开创了第一个远程、无站点的数字临床 试验，现在扩展这一方法，以解决许多其他医疗条件，如健康 怀孕和睡眠障碍。我们的数字审判中心很早就推出了数字参与和跟踪 控制和治疗Scripps(检测)研究，我们的团队在几周内就能够准确地 用被动采集的腕带静息心率数据预测SARS-CoV-2感染的可能性 传感器，然后识别与长Covid相关的生理特征(急性后遗症或 SARS-CoV-2感染)。 斯克里普斯中心将创新临床和翻译科学，以改善人类在整个生命周期和 不同的种族、族裔、地理和社会经济社区。该中心将提供一个培育环境 用于教育、培训和职业发展，重点放在基因组学、数字技术的个性化健康领域 医学和生物医学信息学，以增强未来多样化的劳动力。