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中文摘要
翻译
斯克里普斯转化科学研究所(STSI)旨在支持和促进有影响力的转化科学研究
英文摘要
The Scripps Translational Science Institute (STSI) aims to support and catalyze impactful translational and clinical research for not only the Scripps institutions, consisting of The Scripps Research Institute and Scripps Health, but also an extensive collaborating investigative network that extends from the La Jolia Mesa throughout the United States.The Scripps program combines the largest independent biomedical institute in the country with the dominant health care system in San Diego, along with an extensive partnership with the San Diego Supercomputer Center, one of the 4 national resource centers of its kind. Our areas of innovative infrastructure are informatics, genomics, and wireless medicine. Each area has a remarkably transformative potential for the future of medicine and improving the health of the public. Major advances in genomics and wireless technologies have created data torrents that were previously unimaginable, but with advanced analytical capabilities there is a remarkable opportunity to use such data to individualize medicine, defining each unique human being at multiple levels - biological, physiological, and anatomical. By individualizing medicine, there is a scientific foundation for more effective treatments, avoidance of major side effects, a far more precise means of rendering health care, and lowering of costs. Each individual's data and information can be captured with such new tools as wireless biosensors or sequencing of the entire genome. STSI has particular expertise in these tools, which includes not only gathering the data but also superior analytical capabilites. This sets up an innovative infrastructure to provide disease-agnostic resources and services for a highly productive research network - one that has dismantled the silos that previously existed of basic scientists and clinicians. Furthermore, these resources support the training and career development of the leaders of medicine for the future. RELEVANCE (See instructions): Medicine as practiced today consists of mass screening and the use of the same medications for all patients with a particular diagnosis. Our newfound ability to define the medical essence of each individual paves the way for a more efficient, safer, and less expensive form of healthcare in the future. By bringing together an exceptionally talented and productive research community, STSI will catapult this new form of medicine.
期刊论文(20)
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会议论文
The Anti-α4β7 Integrin Therapeutic Antibody for Inflammatory Bowel Disease, Vedolizumab, Ameliorates Eosinophilic Esophagitis: a Novel Clinical Observation.
用于炎症性肠病的抗α4β7 整合素治疗抗体,Vedolizumab,改善嗜酸粒细胞性食管炎:一项新的临床观察。
DOI: 10.1038/s41395-018-0145-1
发表时间: 2018
期刊: The American journal of gastroenterology
影响因子: --
作者: [Nhu,QuanM, Chiao,Hellen, Moawad,FouadJ, Bao,Fei, Konijeti,GaureeG]
通讯作者: Konijeti,GaureeG
Metastatic Cervical Cancer Causing Esophageal Compression and Dysphagia.
转移性宫颈癌导致食管受压和吞咽困难。
DOI: 10.1016/j.cgh.2018.04.011
发表时间: 2019
期刊: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子: --
作者: [Jahromi,BehnamMoein, Nhu,QuanM, Moawad,FouadJ]
通讯作者: Moawad,FouadJ
DOI: 10.1371/journal.pmed.1002525
发表时间: 2018-03
期刊: PLoS medicine
影响因子: 15.8
作者: [Muse ED, Wineinger NE, Spencer EG, Peters M, Henderson R, Zhang Y, Barrett PM, Rivera SP, Wohlgemuth JG, Devlin JJ, Shiffman D, Topol EJ]
通讯作者: Topol EJ
A rare localised nasal CD30+ primary cutaneous T-cell lymphoma following liver transplantation.
肝移植后罕见的局限性鼻 CD30 原发性皮肤 T 细胞淋巴瘤。
DOI: 10.1136/bcr-2017-221028
发表时间: 2017
期刊: BMJ case reports
影响因子: 0.9
作者: [Nhu,QuanM, Du,EmmaZ, Kiyani,Amirali, Frenette,CatherineT]
通讯作者: Frenette,CatherineT
共 13 条
    Scripps Clinical and Translational Science Hub
    • 批准号:
      10621679
    • 项目类别:
    • 资助金额:
      $602.98万
    • 财政年份:
      2023
    • 负责人:
      Eric Jeffrey Topol
    • 依托单位:
    The Participant Center: Empowering All of Us Research Program participation across the United States
    • 批准号:
      10774158
    • 项目类别:
    • 资助金额:
      $5400.0万
    • 财政年份:
      2023
    • 负责人:
      Eric Jeffrey Topol
    • 依托单位:
    Technology to Empower Changes in Health (TECH) Network Participant Technologies Center
    • 批准号:
      10013434
    • 项目类别:
    • 资助金额:
      $944.61万
    • 财政年份:
      2019
    • 负责人:
      Eric Jeffrey Topol
    • 依托单位:
    Scripps Translational Science Institute
    • 批准号:
      10173181
    • 项目类别:
    • 资助金额:
      $9.78万
    • 财政年份:
      2018
    • 负责人:
      Eric Jeffrey Topol
    • 依托单位:
    海外基金