ABCD-USA Consortium: Coordinating Center

ABCD-美国联盟：协调中心

• 批准号: 10173134
• 负责人: SANDRA A BROWN
• 金额: $ 20万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10173134
• 关键词: 10 year old; Address; Adherence; Adolescence; Adolescent; Adolescent Development; Alcohol or Other Drugs use; Alcohols; American; Area; Behavioral; Benchmarking; Bioinformatics; Biologic Development; Biological Assay; Brain; Child; Child Development; Child Health; Childhood; Communication; Communities; Cultural Sensitivity; Data; Data Analyses; Data Collection; Development; Disputes; Drug abuse; Drug usage; Emotional; Ensure; Environment; Epidemiology; Ethics; Event; Functional disorder; Future; Genetic; Geography; Goals; Human; Human Resources; Image; Individual; Internet; Leadership; Link; Logistics; Magnetic Resonance Imaging; Marijuana; Mental Health; Mentors; Methodology; Mind; Modeling; Monitor; Neurobiology; Neurocognition; Neurocognitive; Outcome; Participant; Patient Recruitments; Pattern; Phenotype; Policies; Population; Procedures; Process; Protocols documentation; Psyche structure; Psychopathology; Publications; Quality Control; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resolution; Risk; Sampling; Scientist; Site; Standardization; Stress; Surveys; Technology; Technology Assessment; Teleconferences; Testing; Time; TimeLine; Training; Trauma; Twin Multiple Birth; Uncertainty; United States National Institutes of Health; Update; Youth; adolescent brain development; adolescent substance use; behavioral health; cognitive neuroscience; cohesion; cohort; computerized; connectome; data quality; data sharing; data warehouse; design; early onset; emerging adult; experience; flexibility; handheld mobile device; health assessment; imaging genetics; imaging study; marijuana use; meetings; misuse of prescription only drugs; multidisciplinary; neuroimaging; novel; outreach; participant retention; programs; real time monitoring; recruit; social culture; success; time use; trend

PROJECT SUMMARY The ABCD-USA Consortium proposes a study designed to permit our investigators and the scientific community to answer important questions about the effects of substance use (SU) on behavioral and brain development of adolescents. We have assembled a team of investigators with unparalleled research experience with youth, and specific expertise in adolescent SU, child and adolescent development, developmental psychopathology, longitudinal multi-site imaging, developmental neuroimaging and cognitive neuroscience, genetics and imaging genetics, bioassays, epidemiology, survey research, bioinformatics, and mobile assessment technologies. We propose a nationwide study of 10,000 9-10 year olds conducted at 21 sites organized into 11 hubs (29% of the US population lives within 50 miles of our geographically spread sites), that, uniquely, can provide a nationally representative sample and a large twin sample that together can help distinguish environmental, sociocultural, and genetic factors relevant to SU and brain development. We ensure cohesion and standardization with a recruitment strategy designed by a professional survey company (experience with Monitoring the Future); standardized environmental, neurocognitive and mental health assessments, MRI assessments with scanners using harmonized Human Connectome Project procedures, and computerized data collection with real-time quality control. Developmentally tailored assessments will have stable sensitivity and construct validity across childhood and adolescence, minimize participant burden, capture even subtle changes in SU, mental health, neurocognition, development, and environment, and employ novel bioassays and passive data collection from mobile devices. The retention plan builds on the experience of our investigators to ensure success. This application describes the ABCD-USA Coordinating Center (CC) which will: provide overall administrative and logistical support and scientific integration for the consortium; establish and implement procedures for core protocols, participant recruitment and retention, and data quality control; provide initial and ongoing training of personnel for standardization; monitor cohort attributes, recruiting and retention practices, data quality, and consortium-wide consistency in real time, and monitor progress toward benchmarks and timelines. CC will ensure adherence to ethical standards and cultural sensitivity of research, and establish and implement policies for dispute resolution, internal and external data sharing, and publication. CC organizes and provides logistical support for meetings and teleconferences of the consortium, steering committee, scientific advisory board and workgroups as well as for educational, scientific, outreach, and dissemination events. By design, CC processes are flexible for problem resolution and incorporation of emerging scientific opportunities. We provide transparent study updates to the public via the web, and a well-managed and fully annotated repository of data for timely sharing. Importantly, we provide training and mentoring to developing scientists in the drug abuse area.

项目总结 ABCD-USA联盟提出了一项研究，旨在允许我们的调查人员和科学工作者 社区回答有关物质使用(SU)对行为和大脑影响的重要问题 青少年的发展。我们已经组建了一支调查团队，进行了无与伦比的研究 青年方面的经验，以及在青春期、儿童和青少年发展方面的专门知识， 发展精神病理学、纵向多部位成像、发育神经成像和认知 神经科学、遗传学和影像遗传学、生物分析、流行病学、调查研究、生物信息学和 移动评估技术。我们建议在全国范围内对10,000名9-10岁的21岁儿童进行研究 组织成11个枢纽的站点(29%的美国人口居住在地理分布的50英里范围内 站点)，唯一可以提供具有全国代表性的样本和大的双胞胎样本，这些样本加在一起可以 帮助区分与SU和大脑发育相关的环境、社会文化和遗传因素。我们 通过由专业调查公司设计的招聘策略确保凝聚力和标准化 (监测未来的经验)；标准化的环境、神经认知和心理健康 评估，使用协调的人类连接组项目程序的扫描仪的磁共振成像评估， 以及具有实时质量控制的计算机化数据收集。为发展量身定做的评估将具有 稳定的敏感度和构建儿童和青春期的效度，最大限度地减少参与者的负担， 捕捉SU、心理健康、神经认知、发育和环境的细微变化，以及 采用新的生物检测方法和从移动设备收集被动数据。保留计划建立在 我们的调查人员的经验确保了成功。此应用程序描述了ABU-USA协调 中心(CC)将：提供全面的行政和后勤支持以及科学整合 建立和执行核心议定书、参与者招募和留用程序，以及 数据质量控制；提供人员的初步和持续标准化培训；监测队列 属性、招聘和保留做法、数据质量和整个财团的实时一致性，以及 监控基准和时间表的进展情况。CC将确保遵守道德标准和文化 研究敏感性，并制定和实施争端解决政策、内部和外部数据 共享和发布。协调委员会组织会议和电话会议并为其提供后勤支持 财团、指导委员会、科学咨询委员会和工作组以及教育、科学、 外展和传播活动。通过设计，CC流程可以灵活地解决问题，并且 纳入新出现的科学机会。我们通过以下途径向公众提供透明的研究更新 网络，以及一个管理良好、注释充分的数据存储库，以便及时共享。重要的是，我们提供 培训和指导药物滥用领域的发展中的科学家。