ABCD-USA Consortium: Coordinating Center

摘要 青少年大脑认知发展（ABCD）是最大的长期研究大脑发育和儿童 美国的健康。ABCD由协调中心、数据分析和信息资源组成 ABCD已经招募了11,880名9-10岁的儿童， 并跟踪他们从青春期到成年早期的生理和行为发展。所有 参与者接受重复的最先进的神经成像，神经心理学测试，生物测定， 青少年和家长对药物使用、心理健康、身体健康以及文化和环境的评估。 2020年3月，当我们的参与者年龄在11-13岁时，世界受到COVID的严重影响- 19大流行病。ABCD在5月、6月、8月和10月向所有参与的青少年及其父母发送了调查问卷 描述流行病对他们的学校教育、经济、压力、物质使用、日常生活的影响， 关系。拟议的项目延长了对大流行病的观察时间，并力求 提高调查数据的答复率和代表性。这些情境信息利用了 现有ABCD数据，以检查大脑发育轨迹中与流行病相关的扰动 功能，认知，物质使用，学术，社会功能和身心健康。 拟议的项目将询问ABCD参与者及其父母关于大流行对其子女的影响。 在学校关闭、失业、疾病传播、信息和错误信息的几个月里， 潜在的，疫苗接种和缓解压力。这将使财团和科学界能够测试 关于大流行病的各个方面如何影响发展的假设。这包括：（1）描述影响 流行病对大脑和认知发展以及物质使用的影响;（2）评估 各种教育方法加剧或减轻了大流行对大脑和认知能力的影响， 发展和物质使用的结果;（3）确定家庭压力因素加剧或 减轻大流行对神经生物学、认知和物质使用结果的影响;以及（4） 评估青少年的短期和长期身体，心理健康，神经和神经认知结果， 患有COVID-19疾病。

Abstract Adolescent Brain Cognitive Development (ABCD) is the largest long-term study of brain development and child health in the United States. ABCD consists of a Coordinating Center, a Data Analysis and Informatics Resource Center, and 21 research sites across the U.S. ABCD has enrolled a diverse sample of 11,880 9-10 year-olds, and is tracking their biological and behavioral development through adolescence into young adulthood. All participants receive repeated state-of-the-art neuroimaging, neuropsychological testing, bioassays, and detailed youth and parent assessments of substance use, mental health, physical health, and culture and environment. In March 2020, when our participants were ages 11-13, the world became substantially affected by the COVID- 19 pandemic. ABCD sent surveys to all participating youth and their parent in May, June, August, and October to characterize the impact of the pandemic in their schooling, economics, stress, substance use, routines, and relationships. The proposed project extends the duration of observation through the pandemic and seeks to increase the response rate and representativeness of the survey data. This situational information leverages existing ABCD data to examine pandemic-related perturbations in developmental trajectories of brain functioning, cognition, substance use, academics, social functioning, and physical and mental health. The proposed project will query ABCD participants and their parents about the impact of the pandemic on their lives over the months of school closures, job loss, disease spread, information and misinformation, and, potentially, vaccinations and easing of stressors. This will allow the consortium and scientific community to test hypotheses on how facets of the pandemic affect development. This includes: (1) characterizing the impact of the pandemic on brain and cognitive development and onset of substance use; (2) evaluating the extent to which various schooling approaches exacerbate or mitigate the impact of the pandemic on brain and cognitive development and substance use outcomes; (3) determining the extent to which family stressors exacerbate or mitigate the impact of the pandemic on neurobiological, cognitive, and substance use outcomes; and (4) evaluating short and long-term physical, mental health, neural, and neurocognitive outcomes in youth who personally had COVID-19 illness.