ABCD-USA Consortium: Coordinating Center

摘要 青少年大脑认知发展(ABCD)是关于大脑发育和儿童的最大的长期研究 美国的健康状况。QUA由一个协调中心、一个数据分析和信息学资源组成 ABCD已经招募了11,880名9-10岁儿童的不同样本， 并跟踪他们从青春期到成年的生物学和行为发展。全 参与者接受重复的最先进的神经成像、神经心理测试、生物分析和详细的 青少年和家长对物质使用、心理健康、身体健康、文化和环境的评估。 2020年3月，当我们的参与者年龄在11-13岁时，世界受到了COVID的重大影响- 19大流行。ABCD在5月、6月、8月和10月对所有参与调查的青少年及其家长进行了调查 描述大流行对他们的教育、经济、压力、物质使用、日常生活和 两性关系。拟议的项目延长了对大流行的观察时间，并寻求 提高调查数据的应答率和代表性。此情景信息利用 现有ABCD数据用于检查脑发育轨迹中与大流行相关的扰动 功能、认知、物质使用、学术、社会功能以及身心健康。 拟议的项目将询问ABU参与者及其父母有关大流行对他们的影响 在学校停课、失业、疾病传播、信息和错误信息的几个月里， 潜在的，接种疫苗和缓解压力。这将使该联盟和科学界能够测试 关于大流行的各个方面如何影响发展的假设。这包括：(1)描述 对大脑和认知发展的大流行以及物质使用的开始；(2)评估 不同的教育方法加剧或减轻大流行对大脑和认知的影响 发展和物质使用结果；(3)确定家庭应激源加剧或 减轻疫情对神经生物学、认知和物质使用结果的影响；以及(4) 评估青少年的短期和长期生理、心理健康、神经和神经认知结果 个人患上了新冠肺炎。

Abstract Adolescent Brain Cognitive Development (ABCD) is the largest long-term study of brain development and child health in the United States. ABCD consists of a Coordinating Center, a Data Analysis and Informatics Resource Center, and 21 research sites across the U.S. ABCD has enrolled a diverse sample of 11,880 9-10 year-olds, and is tracking their biological and behavioral development through adolescence into young adulthood. All participants receive repeated state-of-the-art neuroimaging, neuropsychological testing, bioassays, and detailed youth and parent assessments of substance use, mental health, physical health, and culture and environment. In March 2020, when our participants were ages 11-13, the world became substantially affected by the COVID- 19 pandemic. ABCD sent surveys to all participating youth and their parent in May, June, August, and October to characterize the impact of the pandemic in their schooling, economics, stress, substance use, routines, and relationships. The proposed project extends the duration of observation through the pandemic and seeks to increase the response rate and representativeness of the survey data. This situational information leverages existing ABCD data to examine pandemic-related perturbations in developmental trajectories of brain functioning, cognition, substance use, academics, social functioning, and physical and mental health. The proposed project will query ABCD participants and their parents about the impact of the pandemic on their lives over the months of school closures, job loss, disease spread, information and misinformation, and, potentially, vaccinations and easing of stressors. This will allow the consortium and scientific community to test hypotheses on how facets of the pandemic affect development. This includes: (1) characterizing the impact of the pandemic on brain and cognitive development and onset of substance use; (2) evaluating the extent to which various schooling approaches exacerbate or mitigate the impact of the pandemic on brain and cognitive development and substance use outcomes; (3) determining the extent to which family stressors exacerbate or mitigate the impact of the pandemic on neurobiological, cognitive, and substance use outcomes; and (4) evaluating short and long-term physical, mental health, neural, and neurocognitive outcomes in youth who personally had COVID-19 illness.