ABCD-USA Consortium: Coordinating Center

ABCD-美国联盟：协调中心

• 批准号: 10755471
• 负责人: SANDRA A BROWN
• 金额: $ 76.5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10755471
• 关键词: Address; Adolescence; Adolescent; Area; Behavior; Biological Markers; Blood Pressure; Brain; Child Nutrition; Cholesterol; Collection; Data; Data Collection; Data Coordinating Center; Data Element; Development; Ensure; Environmental Exposure; Ferritin; Future; Glycosylated hemoglobin A; Goals; Health; Health behavior; Heart Rate; Hematology; High Density Lipoproteins; Intervention; Iron; Life Style; Link; Monitor; National Heart, Lung, and Blood Institute; Outcome; Physiological; Population; Population Heterogeneity; Protocols documentation; Recommendation; Research; Research Personnel; Sample Size; Site; Time; Training; Work; Youth; adolescent health; cardiometabolism; cognitive development; cognitive function; cohort; data repository; design; health assessment; open data; physical conditioning; social; sociodemographics

PROJECT SUMMARY/ABSTRACT Adverse cardiometabolic profiles and health behaviors often begin to emerge in adolescence. The following NHLBI Supplement Application outlines the proposal by the Adolescent Brain Cognitive Development (ABCD) Study to augment the current data being collected on this cohort with information about the cardiometabolic and hematologic health of youth during this time period. This additional data will include heart rate and blood pressure, total cholesterol, HDL, HbA1C, CBC, ferritin, iron, and child nutrition. These data will provide key information regarding the physiologic health of youth participating in ABCD and can be correlated with other data on cognitive functioning and brain development. Furthermore, examining the relationship between these physiologic outcomes and social and environmental exposures as well as lifestyle behaviors may help to estimate their impact on adolescent health and identify targets for intervention. ABCD’s large sample size (N=11,880) and diverse population will also enable researchers to develop a more nuanced understanding of these relationships as they pertain to different sociodemographic populations. The data elements to be collected in this supplement will be overseen by the ABCD Physical Health Assessment Workgroup with input from NHLBI. The project will also add ABCD investigators with expertise in these areas to oversee these aspects of the study and ensure scientific integration of analyses addressing several key questions. This group of investigators will join the Physical Health Assessment Workgroup and review the quality of the data collected and make recommendations regarding the collection of future waves of data collection. The Coordinating Center’s data management group (DAIRC) will assist with capturing and monitoring the data. They will also work with the site monitors and research coordinators/assistants at each of the 21 sites to ensure that they receive the training needed to faithfully and accurately implement the designed protocols. Overall, the information gained as part of the supplement will contribute to the open science ABCD data repository, enabling researchers to better understand the connections between physiologic biomarkers, cognitive function, and brain development.

项目摘要/摘要 不良的心脏代谢特征和健康行为通常开始出现在青春期。以下 NHLBI补充申请概述了青少年大脑认知发展（ABCD）的建议 本研究旨在通过有关心脏代谢和 在这段时间里，年轻人的血液健康。这些额外的数据将包括心率和血液 血压、总胆固醇、HDL、HbA 1C、CBC、铁蛋白、铁和儿童营养。这些数据将提供关键 关于参加ABCD的青年的生理健康的信息，并且可以与其他数据相关联 对认知功能和大脑发育的影响此外，研究这些之间的关系 生理结果、社会和环境暴露以及生活方式行为可能有助于 估计其对青少年健康的影响，并确定干预目标。ABCD的大样本量 （N= 11，880）和多样化的人群也将使研究人员能够对以下问题有更细致的了解： 这些关系，因为它们属于不同的社会人口。要收集的数据元素 将由ABCD身体健康评估工作组监督，并由NHLBI输入。 该项目还将增加具有这些领域专业知识的ABCD调查员来监督研究的这些方面 并确保科学地整合针对几个关键问题的分析。这组调查人员将 加入身体健康评估工作组，审查所收集数据的质量， 关于未来数据收集浪潮的建议。协调中心的数据 管理小组（DAIRC）将协助收集和监测数据。他们还将与该网站合作 在21个地点中的每一个地点都有监测员和研究协调员/助理，以确保他们接受培训 需要忠实和准确地执行所设计的协议。总体而言，作为 该补充将有助于开放科学ABCD数据库，使研究人员能够更好地 了解生理生物标志物，认知功能和大脑发育之间的联系。