ABCD-USA Consortium: Coordinating Center

项目摘要/摘要 不良的心脏代谢特征和健康行为通常在青春期开始出现。以下是 NHLBI补充申请概述由青少年大脑认知发展(ABCD)提出的建议 这项研究旨在用心脏代谢和心脏代谢的信息来增强目前在这一队列中收集的数据 这一时期青年的血液健康状况。这些额外的数据将包括心率和血液 血压、总胆固醇、高密度脂蛋白、糖化血红蛋白、红细胞、铁蛋白、铁和儿童营养。这些数据将提供关键 关于参加ABCD的青年的生理健康信息，并可与其他数据相关联 认知功能和大脑发育。此外，考察它们之间的关系 生理结果、社会和环境暴露以及生活方式行为可能有助于 评估其对青少年健康的影响，并确定干预目标。Zong Can的大样本量 (n=11,880)和多样化的人群也将使研究人员能够对 这些关系与不同的社会人口群体有关。要收集的数据元素 本附录中的内容将由身体健康评估工作组监督，NHLBI提供意见。 该项目还将增加在这些领域具有专业知识的调查人员，以监督研究的这些方面 并确保对解决几个关键问题的分析进行科学整合。这组调查人员将 加入身体健康评估工作组，审查收集的数据的质量，并做出 关于收集未来数据收集浪潮的建议。协调中心的数据 管理小组(DAIRC)将协助捕获和监控数据。他们还将与该网站合作 在21个地点中的每个地点进行监测和研究协调员/助理，以确保他们接受培训 需要忠实和准确地执行所设计的协议。总体而言，作为 本附录将有助于开放科学ABCD数据存储库，使研究人员能够更好地 了解生理生物标记物、认知功能和大脑发育之间的联系。

PROJECT SUMMARY/ABSTRACT Adverse cardiometabolic profiles and health behaviors often begin to emerge in adolescence. The following NHLBI Supplement Application outlines the proposal by the Adolescent Brain Cognitive Development (ABCD) Study to augment the current data being collected on this cohort with information about the cardiometabolic and hematologic health of youth during this time period. This additional data will include heart rate and blood pressure, total cholesterol, HDL, HbA1C, CBC, ferritin, iron, and child nutrition. These data will provide key information regarding the physiologic health of youth participating in ABCD and can be correlated with other data on cognitive functioning and brain development. Furthermore, examining the relationship between these physiologic outcomes and social and environmental exposures as well as lifestyle behaviors may help to estimate their impact on adolescent health and identify targets for intervention. ABCD’s large sample size (N=11,880) and diverse population will also enable researchers to develop a more nuanced understanding of these relationships as they pertain to different sociodemographic populations. The data elements to be collected in this supplement will be overseen by the ABCD Physical Health Assessment Workgroup with input from NHLBI. The project will also add ABCD investigators with expertise in these areas to oversee these aspects of the study and ensure scientific integration of analyses addressing several key questions. This group of investigators will join the Physical Health Assessment Workgroup and review the quality of the data collected and make recommendations regarding the collection of future waves of data collection. The Coordinating Center’s data management group (DAIRC) will assist with capturing and monitoring the data. They will also work with the site monitors and research coordinators/assistants at each of the 21 sites to ensure that they receive the training needed to faithfully and accurately implement the designed protocols. Overall, the information gained as part of the supplement will contribute to the open science ABCD data repository, enabling researchers to better understand the connections between physiologic biomarkers, cognitive function, and brain development.