Clinical and Translational Science Award

项目总结 越来越多的突破性生物医学发现的有效转化和成功采用 旨在改善人口健康和缩小健康差距的循证治疗和干预措施 需要具有不同专门知识的多学科和多部门伙伴关系的协调努力， 兴趣和技能。纽约大学(NYU)-卫生和医院公司(HHC)临床和 翻译科学研究所(CTSI)代表着一种创新的公私研究伙伴关系，旨在 促进临床和转化性研究，并改变临床和社区实践中的护理提供。 通过这项申请，我们组建了一个具有独特和互补的机构合作伙伴关系 优势：一所私立研究型大学，拥有公共服务历史和丰富的生物医学、行为学、 和人口健康专家(NYU)，美国最大的市政医疗系统(HHC)，a 州立精神病研究所(Nathan Kline Institute)，以及代表富人的各种社区组织 纽约市人口的多样性。作为集中的枢纽，我们的CTSI促进了研究并促进了访问 必要的核心服务、资源和专业知识，以参与全方位的临床和 在我们的合作机构中进行翻译研究。此外，CTSI是协作的纽带 我们合作机构的调查人员和CTSA中心的全国网络之间的联系。我们将在此基础上 我们成功地在我们的中心显著扩展了临床和翻译研究，并建立了 纽约大学和HHC之间的研究合作，以进一步加快发现的速度和影响， 在翻译研究的整个范围内进行开发、验证和实施。要完成 为了实现这一目标，我们提出了一系列创新的和基于证据的战略，这些战略都在我们的申请中描绘了出来 在六个总体具体目标的框架内。1)催化和支持创新、协作 转化性研究，在我们不同的社区中改善一生的健康。2)确保 本地临床和转化研究的质量、安全性和效率，并传播成功的 接近了。3)鼓励、支持和传播临床和翻译领域的创新方法 科学。4)在我们不同的社区中促进社区参与、协作和基于团队的科学 调查人员和利益攸关方、丰富的伙伴机构和国家CTSA网络。5)教育， 培养、培养下一代翻译研究队伍。6)整合我们的临床， 教育、研究任务和行动，以促进一个学习型医疗保健系统。

PROJECT SUMMARY Increasingly, the effective translation of groundbreaking biomedical discoveries and successful adoption of evidence-based therapies and interventions aimed to improve population health and reduce health disparities requires the coordinated efforts of multi-disciplinary and multi-sectoral partnerships with diverse expertise, interests, and skills. The New York University (NYU)-Health and Hospitals Corporation (HHC) Clinical and Translational Science Institute (CTSI) represents an innovative public-private research partnership designed to foster clinical and translational research and transform the delivery of care in clinical and community practice. With this application, we have assembled a partnership of institutions with unique and complementary strengths: a private research university with a history of public service and substantial biomedical, behavioral, and population health expertise (NYU), the largest municipal healthcare system in the United States (HHC), a state psychiatric institute (Nathan Kline Institute), and various community organizations that represent the rich diversity of populations in NYC. As the centralized hub, our CTSI catalyzes research and facilitates access to essential core services, resources, and expertise necessary to engage in the full spectrum of clinical and translational research across our partner institutions. Moreover, the CTSI serves as a nexus for collaboration between investigators at our partner institutions and the nationwide network of CTSA hubs. We will build on our success in markedly expanding clinical and translational research at our hub and an established history of research collaboration between NYU and HHC to further accelerate the pace and impact of discovery, development, validation, and implementation across the full spectrum of translational research. To accomplish this goal, we propose an array of innovative and evidence-based strategies delineated in our application, all within the framework of six overarching Specific Aims. 1) Catalyze and support innovative, collaborative translational research that improves health across the lifespan in our diverse communities. 2) Ensure the quality, safety, and efficiency of local clinical and translational research and to disseminate successful approaches. 3) Stimulate, support, and disseminate innovative methods in the clinical and translational sciences. 4) Foster community-engaged collaborative and team-based science among our diverse community of investigators and stakeholders, rich array of partner institutions, and the national CTSA network. 5) Educate, train, and cultivate the next generation of the translational research workforce. 6) Integrate our clinical, education, and research missions and operations to foster a learning healthcare system.