Clinical and Translational Science Award

项目摘要 越来越多地，突破性生物医学发现的有效翻译和成功采用 以证据为基础的治疗和干预措施，旨在改善人口健康和减少健康差距 需要具有不同专门知识的多学科和多部门伙伴关系的协调努力， 兴趣和技能。纽约大学（NYU）-健康和医院公司（HHC）临床和 转化科学研究所（CTSI）是一个创新的公私研究伙伴关系，旨在 促进临床和转化研究，并改变临床和社区实践中的护理服务。 有了这个应用程序，我们已经组装了一个独特的和互补的机构的伙伴关系， 优势：一所私立研究型大学，具有公共服务和大量生物医学，行为， 和人口健康专家（纽约大学），美国最大的市政医疗保健系统（HHC）， 国家精神病研究所（内森克莱恩研究所），以及代表富人的各种社区组织 纽约市人口的多样性。作为中心枢纽，我们的CTSI促进研究并促进访问 基本的核心服务，资源和专业知识，从事全方位的临床和 在我们的合作机构进行翻译研究。此外，CTSI还作为合作的纽带 在我们的合作机构和CTSA中心的全国网络的调查员之间。我们将建立在 我们成功地在我们的中心显著扩大临床和转化研究， 纽约大学和HHC之间的研究合作，以进一步加快发现的步伐和影响， 开发，验证和实施整个范围的转化研究。完成 为了实现这一目标，我们提出了一系列创新和基于证据的战略， 在六个总体具体目标的框架内。1)促进和支持创新、协作 转化研究，在我们不同的社区改善整个生命周期的健康。2)确保 质量，安全性和当地临床和转化研究的效率，并传播成功的 接近。3)鼓励，支持和传播临床和转化领域的创新方法 以理工科为重4)在我们多元化的社区中促进社区参与的协作和团队科学 调查人员和利益相关者的参与，丰富的合作伙伴机构，以及国家CTSA网络。5)教育， 培训和培养下一代的翻译研究工作者。6)整合我们的临床， 教育，研究任务和业务，以促进学习医疗保健系统。

PROJECT SUMMARY Increasingly, the effective translation of groundbreaking biomedical discoveries and successful adoption of evidence-based therapies and interventions aimed to improve population health and reduce health disparities requires the coordinated efforts of multi-disciplinary and multi-sectoral partnerships with diverse expertise, interests, and skills. The New York University (NYU)-Health and Hospitals Corporation (HHC) Clinical and Translational Science Institute (CTSI) represents an innovative public-private research partnership designed to foster clinical and translational research and transform the delivery of care in clinical and community practice. With this application, we have assembled a partnership of institutions with unique and complementary strengths: a private research university with a history of public service and substantial biomedical, behavioral, and population health expertise (NYU), the largest municipal healthcare system in the United States (HHC), a state psychiatric institute (Nathan Kline Institute), and various community organizations that represent the rich diversity of populations in NYC. As the centralized hub, our CTSI catalyzes research and facilitates access to essential core services, resources, and expertise necessary to engage in the full spectrum of clinical and translational research across our partner institutions. Moreover, the CTSI serves as a nexus for collaboration between investigators at our partner institutions and the nationwide network of CTSA hubs. We will build on our success in markedly expanding clinical and translational research at our hub and an established history of research collaboration between NYU and HHC to further accelerate the pace and impact of discovery, development, validation, and implementation across the full spectrum of translational research. To accomplish this goal, we propose an array of innovative and evidence-based strategies delineated in our application, all within the framework of six overarching Specific Aims. 1) Catalyze and support innovative, collaborative translational research that improves health across the lifespan in our diverse communities. 2) Ensure the quality, safety, and efficiency of local clinical and translational research and to disseminate successful approaches. 3) Stimulate, support, and disseminate innovative methods in the clinical and translational sciences. 4) Foster community-engaged collaborative and team-based science among our diverse community of investigators and stakeholders, rich array of partner institutions, and the national CTSA network. 5) Educate, train, and cultivate the next generation of the translational research workforce. 6) Integrate our clinical, education, and research missions and operations to foster a learning healthcare system.