Engineering Personalized Devices for Craniomaxillofacial Defects

针对颅颌面缺陷设计个性化设备

基本信息

  • 批准号:
    10116988
  • 负责人:
  • 金额:
    $ 38.58万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-03-01 至 2024-02-29
  • 项目状态:
    已结题

项目摘要

Appropriate restoration of form and function of the missing skeletal tissue of growing children is a remarkable challenge. Defects in the craniomaxillofacial bones of young children represent a significant emotional and economic burden as their restoration/regeneration often requires multiple bone grafting procedures (usually procured from the skull, hip, or ribs) for adequate treatment outcomes as the child grows. The recent development of custom 3D printed degradable bioactive ceramic scaffolds that can fit and fill large bone defects and quickly regenerate bone within defect margins may provide a novel solution and coating these scaffolds with agents designed to promote more rapid and complete bone healing may increase the efficacy of craniomaxillofacial bone defect treatment in growing children. Such an approach would eliminate the necessity for secondary surgical sites for bone graft procurement and has tremendous potential to minimize/eliminate multiple surgical procedures due to child growth, as the regenerated bone will follow the growth of adjacent structures. The development of such a treatment option for skeletal defects would be an unprecedented advance in bone reconstructive surgery of both growing children and that of adults. We have recently conducted preliminary studies where customized 3D printed degradable bioactive ceramic scaffolds coated with agents, which stimulate adenosine receptors (i.e. dipyridamole), remarkably enhanced bone regeneration. The cellular and molecular basis for this effect is currently under investigation under 1R01AR068593-01. Through this approach, we have successfully regenerated vascularized bone in rabbit models ranging from critical size segmental defects of long bones and mandible to critical size defects of extremely thin and flat bones of the craniomaxillofacial complex. Thus, we propose to test the hypothesis that 3D printed degradable bioactive ceramic scaffolds coated with dipyridamole can promote rapid bone regeneration into a defect and that the regenerated bone will normally follow adjacent structures’ growth and development in skeletally immature subjects until full skeletal growth is complete. We therefore propose the following aims: To maximize the combination of dipyridamole with personalized 3D printed bioactive scaffolds for the repair of craniomaxillofacial defects in skeletally immature subjects and monitor the regenerated bone over time. After successfully completing Aim I (R21), we will translate the developed technology to regenerate and monitor over an extended period of time clinically relevant (human size) craniomaxillofacial defects in skeletally immature highly translational large animal species, which presents bone tissue growth dynamics more similar to human. Aim II. (R33) To translate the developed personalized 3D printed bioactive ceramic scaffolds to treat craniomaxillofacial bone defects in a skeletally immature highly translational animal species and monitor the regenerated bone growth over time.
适当地恢复生长期儿童缺失的骨骼组织的形式和功能是一个值得注意的 挑战.幼儿颅颌面骨的缺陷代表了一个重要的情感和 经济负担,因为它们的恢复/再生通常需要多次骨移植手术(通常 从头骨、臀部或肋骨获得),以便随着孩子的成长获得足够的治疗效果。近期 开发定制的3D打印可降解生物活性陶瓷支架,可以适应和填充大骨 缺损和在缺损边缘内快速再生的骨可以提供新的解决方案, 具有被设计为促进更快速和完全的骨愈合的试剂的支架可以增加 生长期儿童颅颌面骨缺损的治疗这种做法将消除 用于骨移植物获取的二次手术部位,具有极大的潜力, 由于儿童生长,再生骨将跟随相邻骨的生长, 结构.开发这种骨骼缺陷治疗方案将是前所未有的 儿童和成人骨重建手术的进展。我们最近 进行了初步研究,其中定制的3D打印可降解生物活性陶瓷支架涂层 与刺激腺苷受体的药物(即双嘧达莫)一起使用,显著增强了骨再生。 目前正在1 R 01 AR 068593 -01下研究该效应的细胞和分子基础。 通过这种方法,我们成功地在兔模型中再生了血管化骨, 从长骨和下颌骨的临界尺寸节段性缺损到极薄和扁平的临界尺寸缺损 颅颌面复合体的骨头。因此,我们建议测试3D打印可降解的假设, 涂有双嘧达莫的生物活性陶瓷支架可以促进骨快速再生到缺损处, 再生骨通常会跟随邻近结构的生长和发育, 直到骨骼完全生长完成。因此,我们提出以下目标: 最大化双嘧达莫与个性化3D打印生物活性支架的组合, 未成年人颅颌面缺损的修复及骨再生监测 随着时间在成功完成目标I(R21)后,我们将把开发的技术转化为再生能源, 并在较长时间内监测临床相关(人体尺寸)颅颌面缺损, 骨骼发育不成熟的高度平移的大型动物物种,其呈现骨组织生长动力学 更像人类。Aim II. (R33)将开发的个性化3D打印生物活性 陶瓷支架治疗颅颌面骨缺损的实验研究 动物物种,并监测随着时间的推移再生骨生长。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

BRUCE Neil CRONSTEIN其他文献

BRUCE Neil CRONSTEIN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('BRUCE Neil CRONSTEIN', 18)}}的其他基金

Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10255087
  • 财政年份:
    2020
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10320492
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10183901
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10317650
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    9085750
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10289909
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10310799
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    9252686
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10382896
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10174469
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:

相似海外基金

Study on the use of 3D print models to improve understanding of geomorphic processes
研究使用 3D 打印模型来提高对地貌过程的理解
  • 批准号:
    22K13777
  • 财政年份:
    2022
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
3D print-on-demand technology for personalised medicines at the point of care
用于护理点个性化药物的 3D 按需打印技术
  • 批准号:
    10045111
  • 财政年份:
    2022
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Grant for R&D
Regenerative cooling optimisation in 3D-print rocket nozzles
3D 打印火箭喷嘴的再生冷却优化
  • 批准号:
    2749141
  • 财政年份:
    2022
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Studentship
Development of a New Powder Mix and Process Plan to 3D Print Ductile Iron Parts
开发用于 3D 打印球墨铸铁零件的新粉末混合物和工艺计划
  • 批准号:
    548945-2019
  • 财政年份:
    2021
  • 资助金额:
    $ 38.58万
  • 项目类别:
    College - University Idea to Innovation Grants
Development of a New Powder Mix and Process Plan to 3D Print Ductile Iron Parts
开发用于 3D 打印球墨铸铁零件的新粉末混合物和工艺计划
  • 批准号:
    548945-2019
  • 财政年份:
    2020
  • 资助金额:
    $ 38.58万
  • 项目类别:
    College - University Idea to Innovation Grants
Administrative Supplement for Equipment: 6-axis Positioner to Improve 3D Print Quality and Print Size
设备管理补充:用于提高 3D 打印质量和打印尺寸的 6 轴定位器
  • 批准号:
    10801667
  • 财政年份:
    2019
  • 资助金额:
    $ 38.58万
  • 项目类别:
SBIR Phase II: Pellet based 3D print extrusion process for shoe manufacturing
SBIR 第二阶段:用于制鞋的基于颗粒的 3D 打印挤出工艺
  • 批准号:
    1738138
  • 财政年份:
    2017
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Standard Grant
Development of "artificial muscle' ink for 3D print of microrobots
开发用于微型机器人3D打印的“人造肌肉”墨水
  • 批准号:
    17K18852
  • 财政年份:
    2017
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
I-Corps: Nanochon, a Commercial Venture to 3D Print Regenerative Implants for Joint Reconstruction
I-Corps:Nanochon,一家商业企业,致力于 3D 打印再生植入物进行关节重建
  • 批准号:
    1612567
  • 财政年份:
    2016
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Standard Grant
SBIR Phase I: Pellet based 3D print extrusion process for shoe manufacturing
SBIR 第一阶段:用于制鞋的基于颗粒的 3D 打印挤出工艺
  • 批准号:
    1621732
  • 财政年份:
    2016
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了