Engineering Personalized Devices for Craniomaxillofacial Defects

针对颅颌面缺陷设计个性化设备

基本信息

  • 批准号:
    10116988
  • 负责人:
  • 金额:
    $ 38.58万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-03-01 至 2024-02-29
  • 项目状态:
    已结题

项目摘要

Appropriate restoration of form and function of the missing skeletal tissue of growing children is a remarkable challenge. Defects in the craniomaxillofacial bones of young children represent a significant emotional and economic burden as their restoration/regeneration often requires multiple bone grafting procedures (usually procured from the skull, hip, or ribs) for adequate treatment outcomes as the child grows. The recent development of custom 3D printed degradable bioactive ceramic scaffolds that can fit and fill large bone defects and quickly regenerate bone within defect margins may provide a novel solution and coating these scaffolds with agents designed to promote more rapid and complete bone healing may increase the efficacy of craniomaxillofacial bone defect treatment in growing children. Such an approach would eliminate the necessity for secondary surgical sites for bone graft procurement and has tremendous potential to minimize/eliminate multiple surgical procedures due to child growth, as the regenerated bone will follow the growth of adjacent structures. The development of such a treatment option for skeletal defects would be an unprecedented advance in bone reconstructive surgery of both growing children and that of adults. We have recently conducted preliminary studies where customized 3D printed degradable bioactive ceramic scaffolds coated with agents, which stimulate adenosine receptors (i.e. dipyridamole), remarkably enhanced bone regeneration. The cellular and molecular basis for this effect is currently under investigation under 1R01AR068593-01. Through this approach, we have successfully regenerated vascularized bone in rabbit models ranging from critical size segmental defects of long bones and mandible to critical size defects of extremely thin and flat bones of the craniomaxillofacial complex. Thus, we propose to test the hypothesis that 3D printed degradable bioactive ceramic scaffolds coated with dipyridamole can promote rapid bone regeneration into a defect and that the regenerated bone will normally follow adjacent structures’ growth and development in skeletally immature subjects until full skeletal growth is complete. We therefore propose the following aims: To maximize the combination of dipyridamole with personalized 3D printed bioactive scaffolds for the repair of craniomaxillofacial defects in skeletally immature subjects and monitor the regenerated bone over time. After successfully completing Aim I (R21), we will translate the developed technology to regenerate and monitor over an extended period of time clinically relevant (human size) craniomaxillofacial defects in skeletally immature highly translational large animal species, which presents bone tissue growth dynamics more similar to human. Aim II. (R33) To translate the developed personalized 3D printed bioactive ceramic scaffolds to treat craniomaxillofacial bone defects in a skeletally immature highly translational animal species and monitor the regenerated bone growth over time.
适当的形式和功能的恢复缺失的骨骼组织的成长中的儿童是一个显着的

项目成果

期刊论文数量(0)
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BRUCE Neil CRONSTEIN其他文献

BRUCE Neil CRONSTEIN的其他文献

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{{ truncateString('BRUCE Neil CRONSTEIN', 18)}}的其他基金

Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10255087
  • 财政年份:
    2020
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10320492
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10183901
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10317650
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    9085750
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10289909
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10310799
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    9252686
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10382896
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10174469
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:

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