Engineering Personalized Devices for Craniomaxillofacial Defects

针对颅颌面缺陷设计个性化设备

基本信息

  • 批准号:
    10116988
  • 负责人:
  • 金额:
    $ 38.58万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-03-01 至 2024-02-29
  • 项目状态:
    已结题

项目摘要

Appropriate restoration of form and function of the missing skeletal tissue of growing children is a remarkable challenge. Defects in the craniomaxillofacial bones of young children represent a significant emotional and economic burden as their restoration/regeneration often requires multiple bone grafting procedures (usually procured from the skull, hip, or ribs) for adequate treatment outcomes as the child grows. The recent development of custom 3D printed degradable bioactive ceramic scaffolds that can fit and fill large bone defects and quickly regenerate bone within defect margins may provide a novel solution and coating these scaffolds with agents designed to promote more rapid and complete bone healing may increase the efficacy of craniomaxillofacial bone defect treatment in growing children. Such an approach would eliminate the necessity for secondary surgical sites for bone graft procurement and has tremendous potential to minimize/eliminate multiple surgical procedures due to child growth, as the regenerated bone will follow the growth of adjacent structures. The development of such a treatment option for skeletal defects would be an unprecedented advance in bone reconstructive surgery of both growing children and that of adults. We have recently conducted preliminary studies where customized 3D printed degradable bioactive ceramic scaffolds coated with agents, which stimulate adenosine receptors (i.e. dipyridamole), remarkably enhanced bone regeneration. The cellular and molecular basis for this effect is currently under investigation under 1R01AR068593-01. Through this approach, we have successfully regenerated vascularized bone in rabbit models ranging from critical size segmental defects of long bones and mandible to critical size defects of extremely thin and flat bones of the craniomaxillofacial complex. Thus, we propose to test the hypothesis that 3D printed degradable bioactive ceramic scaffolds coated with dipyridamole can promote rapid bone regeneration into a defect and that the regenerated bone will normally follow adjacent structures’ growth and development in skeletally immature subjects until full skeletal growth is complete. We therefore propose the following aims: To maximize the combination of dipyridamole with personalized 3D printed bioactive scaffolds for the repair of craniomaxillofacial defects in skeletally immature subjects and monitor the regenerated bone over time. After successfully completing Aim I (R21), we will translate the developed technology to regenerate and monitor over an extended period of time clinically relevant (human size) craniomaxillofacial defects in skeletally immature highly translational large animal species, which presents bone tissue growth dynamics more similar to human. Aim II. (R33) To translate the developed personalized 3D printed bioactive ceramic scaffolds to treat craniomaxillofacial bone defects in a skeletally immature highly translational animal species and monitor the regenerated bone growth over time.
适当地恢复发育中儿童缺失的骨骼组织的形态和功能是值得注意的 挑战。幼儿颅颌面骨的缺陷表现为显著的情感和 经济负担,因为它们的修复/再生通常需要多次植骨手术(通常 从头骨、臀部或肋骨获取),以便在孩子成长过程中获得足够的治疗结果。最近的 定制3D打印可降解生物活性陶瓷支架的研制 并在缺损区边缘快速再生骨可以提供一种新的解决方案,并将这些涂层 使用旨在促进更快和更完全的骨愈合的药物的支架可能会增加 生长中儿童颅颌面骨缺损的治疗。这样的方法将消除这种必要性 用于二次手术部位的骨移植采购,具有最大限度地减少/消除的巨大潜力 由于孩子的成长需要多次手术,因为再生的骨会跟随邻近部位的生长。 结构。这种骨缺陷治疗方案的开发将是史无前例的 儿童和成人骨重建手术的研究进展。我们最近做了 进行了定制3D打印可降解生物活性陶瓷支架涂层的初步研究 使用刺激腺苷受体的试剂(即潘生丁),可以显著促进骨再生。 这种效应的细胞和分子基础目前正在1R01AR068593-01项下进行研究。 通过这种方法,我们已经成功地在兔模型中再生了带血管的骨 长骨和下颌骨的临界大小节段性缺损到极薄扁平的临界大小的缺损 颅颌面复合体的骨骼。因此,我们建议测试3D打印可降解的假设 双嘧达莫涂层生物活性陶瓷支架可促进骨组织的快速再生 再生的骨骼通常会跟随邻近结构在骨骼中的生长发育 未成熟的受试者,直到骨骼完全发育完成。因此,我们提出以下目标: 最大限度地将潘生丁与个性化3D打印生物活性支架结合在一起 骨质疏松症患者颅颌面缺损的修复及再生骨监测 随着时间的推移。在成功完成目标I(R21)后,我们将把开发的技术转化为再生 并在很长一段时间内监测临床相关的(人体大小)颅颌面部缺陷 骨骼不成熟、高度平移的大型动物物种,呈现骨组织生长动力学 更接近人类。目的二、(R33)翻译开发的个性化3D打印生物活性 陶瓷支架修复骨质疏松症高转移性颅颌面骨缺损 动物种类,并监测随着时间的推移再生的骨骼生长。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

BRUCE Neil CRONSTEIN其他文献

BRUCE Neil CRONSTEIN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('BRUCE Neil CRONSTEIN', 18)}}的其他基金

Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10255087
  • 财政年份:
    2020
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10320492
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10183901
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10317650
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    9085750
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10289909
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10310799
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    9252686
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10382896
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:
Clinical and Translational Science Award
临床和转化科学奖
  • 批准号:
    10174469
  • 财政年份:
    2015
  • 资助金额:
    $ 38.58万
  • 项目类别:

相似海外基金

Study on the use of 3D print models to improve understanding of geomorphic processes
研究使用 3D 打印模型来提高对地貌过程的理解
  • 批准号:
    22K13777
  • 财政年份:
    2022
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
3D print-on-demand technology for personalised medicines at the point of care
用于护理点个性化药物的 3D 按需打印技术
  • 批准号:
    10045111
  • 财政年份:
    2022
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Grant for R&D
Regenerative cooling optimisation in 3D-print rocket nozzles
3D 打印火箭喷嘴的再生冷却优化
  • 批准号:
    2749141
  • 财政年份:
    2022
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Studentship
Development of a New Powder Mix and Process Plan to 3D Print Ductile Iron Parts
开发用于 3D 打印球墨铸铁零件的新粉末混合物和工艺计划
  • 批准号:
    548945-2019
  • 财政年份:
    2021
  • 资助金额:
    $ 38.58万
  • 项目类别:
    College - University Idea to Innovation Grants
Development of a New Powder Mix and Process Plan to 3D Print Ductile Iron Parts
开发用于 3D 打印球墨铸铁零件的新粉末混合物和工艺计划
  • 批准号:
    548945-2019
  • 财政年份:
    2020
  • 资助金额:
    $ 38.58万
  • 项目类别:
    College - University Idea to Innovation Grants
Administrative Supplement for Equipment: 6-axis Positioner to Improve 3D Print Quality and Print Size
设备管理补充:用于提高 3D 打印质量和打印尺寸的 6 轴定位器
  • 批准号:
    10801667
  • 财政年份:
    2019
  • 资助金额:
    $ 38.58万
  • 项目类别:
SBIR Phase II: Pellet based 3D print extrusion process for shoe manufacturing
SBIR 第二阶段:用于制鞋的基于颗粒的 3D 打印挤出工艺
  • 批准号:
    1738138
  • 财政年份:
    2017
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Standard Grant
Development of "artificial muscle' ink for 3D print of microrobots
开发用于微型机器人3D打印的“人造肌肉”墨水
  • 批准号:
    17K18852
  • 财政年份:
    2017
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
I-Corps: Nanochon, a Commercial Venture to 3D Print Regenerative Implants for Joint Reconstruction
I-Corps:Nanochon,一家商业企业,致力于 3D 打印再生植入物进行关节重建
  • 批准号:
    1612567
  • 财政年份:
    2016
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Standard Grant
SBIR Phase I: Pellet based 3D print extrusion process for shoe manufacturing
SBIR 第一阶段:用于制鞋的基于颗粒的 3D 打印挤出工艺
  • 批准号:
    1621732
  • 财政年份:
    2016
  • 资助金额:
    $ 38.58万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了