Clinical and Translational Science Award

临床和转化科学奖

• 批准号: 10317650
• 负责人: BRUCE Neil CRONSTEIN
• 金额: $ 2034.35万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-18 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10317650
• 关键词: Acceleration; Address; Adopted; Agreement; Award; Caring; Catalogs; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Data; Development; Device or Instrument Development; Discipline; Drug Delivery Systems; Effectiveness; Electronic Health Record; Ensure; Environment; Ethnic group; Fostering; Fruit; Funding; Gap Junctions; Good Clinical Practice; Health; Healthcare Systems; Hospitals; Informatics; Infrastructure; Institutes; Institution; Licensing; Life; Longevity; Medical; Methodology; Methods; Mission; Modeling; Multicenter Trials; Municipalities; New York; New York City; Outcome; Patients; Phase; Population; Population Heterogeneity; Privatization; Procedures; Process; Provider; Publications; Race; Recording of previous events; Reproducibility; Research; Research Institute; Research Personnel; Research Support; Research Training; Resources; Safety; Schools; Science; Scientific Advances and Accomplishments; Services; Site; Special Population; Special Populations Research; Speed; Technology; Training; Training Programs; Training Support; Training and Education; Translating; Translational Research; Translations; United States; United States National Library of Medicine; Universities; Validation; Vision; Workforce Development; behavioral health; college; community organizations; data management; data sharing; design; digital; drug development; education resources; electronic data; epidemiology study; evidence base; health care delivery; health difference; health disparity; high dimensionality; improved; innovation; interest; medical schools; member; metropolitan; multidisciplinary; multiple omics; next generation; novel; patient oriented; population health; programs; protocol violation; public-private partnership; racial diversity; recruit; skills; training opportunity; translational pipeline; translational scientist; wearable device

Contact PD/PI: CRONSTEIN, BRUCE Neil O. OVERALL – PROJECT SUMMARY The translation and implementation of groundbreaking biomedical discoveries requires the dynamic coordination of multi-disciplinary partnerships with diverse expertise, interests, and skills. The New York University (NYU) Clinical and Translational Science Institute (CTSI) represents an innovative public–private partnership designed to foster clinical and translational research, adopt evidence-based therapies, and apply scientific discoveries to transform the delivery of medical care and improve health. The CTSI successfully leveraged a partnership of institutions with unique and complementary strengths to translate science into better health, including: NYU, a private research university with a history of public service, substantial biomedical, behavioral, and population health expertise, and robust education and training programs; New York City Health and Hospitals (H+H), the largest municipal healthcare system in the United States; Nathan Kline Institute (NKI), a state psychiatric institute affiliated with NYU; and community organizations representing the richly diverse population of NYC. As the centralized hub that coordinates and integrates activities across these partners, our CTSI catalyzes research and facilitates access to essential core services, resources, and expertise necessary to engage in the full spectrum of clinical and translational research across our partner institutions. We provide educational and training opportunities for our diverse research workforce. Moreover, the CTSI serves as a nexus for collaboration between investigators at our partner institutions and the nationwide network of CTSA hubs. We more than doubled self-identified clinical and translational research at our hub over the past 10 years and established collaborations between NYU, the schools and colleges of NYU, and H+H to further accelerate the pace and impact of discovery, development, validation, and implementation across the full spectrum of translational research. We now propose an array of innovative and evidence-based strategies within the framework of the strategic domains enunciated by NCATS including: 1) Methods/Processes to streamline regulatory processes, improve the efficiency, quality, and reproducibility of research and increase the rate of implementation of research advances; 2) Collaboration/Engagement with communities, patients, providers, and researchers to elucidate and disseminate best practices and guiding principles of team science to improve translational research and health outcomes; 3) Informatics to provide a strong and innovative digital environment for subject recruitment, data management, analysis, discovery, and sharing as well as access to an extensive digital warehouse with data from electronic health records, epidemiologic studies, clinical trials, multi-omic analyses, and biospecimens; 4) Integration Across the Lifespan with Community and Patient Stakeholders to engage diverse NYC communities and special populations across the lifespan; and 5) Workforce Development to advance our efforts to educate, train, and cultivate the next generation of the translational research workforce. Project Summary/Abstract Page 302 Contact PD/PI: CRONSTEIN, BRUCE Neil O. OVERALL –

联系PD/PI：CRONSTEIN，布鲁斯Neil O.总体-项目摘要 突破性生物医学发现的转化和实施需要动态协调 具有不同专业知识、兴趣和技能的多学科合作伙伴关系。纽约大学（NYU） 临床和转化科学研究所（CTSI）是一个创新的公私合作伙伴关系， 促进临床和转化研究，采用循证疗法，并将科学发现应用于 改变医疗服务的提供方式，改善健康状况。CTSI成功地利用了 具有独特和互补优势的机构，将科学转化为更好的健康，包括：纽约大学， 一所私立研究型大学，具有公共服务，大量生物医学，行为和人口的历史 卫生专业知识，以及强大的教育和培训计划;纽约市卫生和医院（H+H）， 美国最大的市政医疗保健系统; Nathan Kline研究所（NKI），一家州立精神病研究所 隶属于纽约大学;和社区组织代表纽约市丰富多样的人口。为 作为协调和整合这些合作伙伴活动的集中式枢纽，我们的CTSI促进了研究 并促进获得必要的核心服务、资源和专业知识， 在我们的合作机构中开展临床和转化研究。我们提供教育和 为我们多样化的研究队伍提供培训机会。此外，CTSI还作为合作的纽带 在我们的合作机构和CTSA中心的全国网络的调查员之间。我们比 在过去的10年里，我们的中心将自我鉴定的临床和转化研究增加了一倍，并建立了 纽约大学，纽约大学的学校和学院以及H+H之间的合作，以进一步加快步伐， 发现、开发、验证和实施对整个翻译领域的影响 research.我们现在提出了一系列创新和以证据为基础的战略框架内， NCATS阐述的战略领域包括：1）简化监管流程的方法/流程， 提高研究的效率、质量和可重复性，并提高 研究进展; 2）与社区，患者，供应商和研究人员的合作/参与， 阐明和传播团队科学的最佳实践和指导原则，以改善转化研究 信息学为受试者提供强大和创新的数字环境 招聘、数据管理、分析、发现和共享，以及访问广泛的数字 数据仓库，包含来自电子健康记录、流行病学研究、临床试验、多组学分析 和生物标本; 4）与社区和患者利益相关者在整个生命周期内进行整合， 不同的纽约市社区和特殊人群在整个生命周期;和5）劳动力发展， 推进我们的努力，教育，培训和培养下一代的转化研究工作队伍。 项目摘要/摘要第302页 联系PD/PI：CRONSTEIN，布鲁斯Neil O.总体而言，