Clinical and Translational Science Award

父级奖项--项目总结 生物医学突破性发现的转化和实施需要动态协调 具有不同专业知识、兴趣和技能的多学科伙伴关系。纽约大学(NYU) 临床和转化科学研究所(CTSI)代表着一种创新的公私合作伙伴关系，旨在 促进临床和转化研究，采用循证疗法，并将科学发现应用于 转变医疗服务方式，改善健康状况。CTSI成功地利用了 具有独特和互补优势的机构，将科学转化为更好的健康，包括：纽约大学，a 私立研究型大学，有公共服务的历史，有大量的生物医学、行为和人口 卫生专业知识以及强有力的教育和培训计划；纽约市卫生和医院(H H)， 美国最大的市政医疗系统；内森·克莱恩研究所(NKI)，一家州立精神病研究所 隶属于纽约大学；以及代表纽约市丰富多样人口的社区组织。作为 我们的CTSI是协调和整合这些合作伙伴活动的集中式中心，它催化研究 并促进获得必要的核心服务、资源和专业知识，以充分参与 我们合作机构的临床和转化性研究的范围。我们提供教育和 为我们多样化的研究人员提供培训机会。此外，CTSI是协作的纽带 我们合作机构的调查人员和CTSA中心的全国网络之间的联系。我们不仅仅是 在过去的10年里，我们中心的自我确认的临床和转化研究增加了一倍，并建立了 纽约大学、纽约大学的学校和学院以及H H之间的合作，以进一步加快步伐和 发现、开发、验证和实施对整个翻译领域的影响 研究。我们现在提出一系列创新和以证据为基础的战略，在 NCATS阐述的战略领域包括：1)简化监管流程的方法/流程； 提高研究的效率、质量和可重复性，提高研究的实施率 研究进展；2)与社区、患者、提供者和研究人员协作/参与，以 阐明和传播团队科学的最佳实践和指导原则，以改进翻译研究 和健康结果；3)信息学为受试者提供强大和创新的数字环境 招聘、数据管理、分析、发现和共享以及访问广泛的数字 电子健康记录、流行病学研究、临床试验、多组学分析、 和生物制品；4)与社区和患者利益相关者在整个生命周期内进行整合，以参与 不同的纽约市社区和特殊人群的寿命；以及5)劳动力发展 推进教育、培训和培养下一代翻译研究队伍的努力。

PARENT AWARD - PROJECT SUMMARY The translation and implementation of groundbreaking biomedical discoveries requires the dynamic coordination of multi-disciplinary partnerships with diverse expertise, interests, and skills. The New York University (NYU) Clinical and Translational Science Institute (CTSI) represents an innovative public–private partnership designed to foster clinical and translational research, adopt evidence-based therapies, and apply scientific discoveries to transform the delivery of medical care and improve health. The CTSI successfully leveraged a partnership of institutions with unique and complementary strengths to translate science into better health, including: NYU, a private research university with a history of public service, substantial biomedical, behavioral, and population health expertise, and robust education and training programs; New York City Health and Hospitals (H+H), the largest municipal healthcare system in the United States; Nathan Kline Institute (NKI), a state psychiatric institute affiliated with NYU; and community organizations representing the richly diverse population of NYC. As the centralized hub that coordinates and integrates activities across these partners, our CTSI catalyzes research and facilitates access to essential core services, resources, and expertise necessary to engage in the full spectrum of clinical and translational research across our partner institutions. We provide educational and training opportunities for our diverse research workforce. Moreover, the CTSI serves as a nexus for collaboration between investigators at our partner institutions and the nationwide network of CTSA hubs. We more than doubled self-identified clinical and translational research at our hub over the past 10 years and established collaborations between NYU, the schools and colleges of NYU, and H+H to further accelerate the pace and impact of discovery, development, validation, and implementation across the full spectrum of translational research. We now propose an array of innovative and evidence-based strategies within the framework of the strategic domains enunciated by NCATS including: 1) Methods/Processes to streamline regulatory processes, improve the efficiency, quality, and reproducibility of research and increase the rate of implementation of research advances; 2) Collaboration/Engagement with communities, patients, providers, and researchers to elucidate and disseminate best practices and guiding principles of team science to improve translational research and health outcomes; 3) Informatics to provide a strong and innovative digital environment for subject recruitment, data management, analysis, discovery, and sharing as well as access to an extensive digital warehouse with data from electronic health records, epidemiologic studies, clinical trials, multi-omic analyses, and biospecimens; 4) Integration Across the Lifespan with Community and Patient Stakeholders to engage diverse NYC communities and special populations across the lifespan; and 5) Workforce Development to advance our efforts to educate, train, and cultivate the next generation of the translational research workforce.