Neuropathology Core

神经病理学核心

• 批准号: 10176345
• 负责人: Thomas J Montine
• 金额: $ 40.89万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10176345
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Autopsy; Award; Biological Assay; Biological Markers; Brain; Brain region; Clinical Data; Cognitive; Consensus; Country; Data; Dementia; Development; Diagnostic; Discipline; Disease; Environment; Evaluation; Faculty; Formalin; Fostering; Freezing; Future; Guidelines; Image; Impaired cognition; Individual; Interdisciplinary Study; International; Leadership; Medical Students; Methods; Mission; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Outreach Research; Paraffin Embedding; Pathologic; Pathologic Processes; Patients; Physicians; Positioning Attribute; Process; Reporting; Research; Research Personnel; Resource Sharing; Scientist; Specimen; Structure; Techniques; Technology; Time; Tissue Embedding; Tissues; Training; Translational Research; Vision; aging brain; biobank; brain research; brain tissue; data management; data quality; education research; graduate student; imaging approach; innovation; innovative technologies; insight; molecular pathology; neuropathology; repository; research study; statistics

1. SUMMARY (Neuropathology Core) The Neuropathology Core supports the vision of the Stanford Alzheimer’s Disease Center (ADRC) to serve as a shared resource to facilitate and enhance multidisciplinary and interdisciplinary research in Alzheimer’s disease (AD) and related disorders. The Core is structured to continue its track record of enabling and applying innovative cutting-edge technologies with emphasis on brain aging and the diversity of pathologic processes that underlie cognitive impairment and dementia caused by AD and related diseases. The critical functions of the Neuropathology Core include diagnostic expertise, serving as a biorepository, facilitating innovation, and training. Over the past five years, the Neuropathology Core has completed over 50 research brain autopsies and held a leadership position in setting and evaluating national research guidelines for neuropathologic evaluation of AD. We have banked over 800 tissue specimens, contributed data and biospecimens to local, regional, national, and international research studies and consortia, and fostered development and implementation of innovative technologies in translational research. Through the Core, we trained clinicians and scientists from different disciplines in neuropathology and the molecular pathology of dementia-related neurodegenerative diseases. The Neuropathology Core will pursue its mission through four Specific Aims. The Core will provide comprehensive neuropathologic evaluations for physicians and researchers with timely and comprehensive autopsy reports that describe the neuropathologic features of AD and related diseases according to the most current guidelines and consensus diagnostic criteria. It will maintain and continue to grow its highly accessible, but appropriately safeguarded, repository of brain tissue and biospecimens from carefully and longitudinally characterized patients with cognitive impairment or dementia, as well as cognitively normal individuals, using methods that increase and maximize tissue and data quality. In doing so, the Core will empower innovative high-content imaging approaches for both formalin-fixed, paraffin-embedded tissue and for frozen brain regions to maximize the research value of the Stanford ADRC repository and other brain banks around the country. Finally, we will maintain a rich training environment for medical and graduate students, residents, fellows, and junior faculty across departments to teach concepts and state-of-the-art techniques that advance current interdisciplinary research and foster future advances and insights in brain aging and neurodegeneration. The Core is organized to maximize integration with all other Cores in the Stanford ADRC. It also will continue to serve as a hub of support for affiliated ADRCs and independent research awards through diagnostic practices, molecular assays, and tissue sharing. In doing so, the Core and Center will continue to contribute nationally to advance our understanding of the pathologic features and pathophysiologic processes of brain aging, all stages of AD, and related dementias.

1. 摘要（神经病理学核心） 神经病理学核心支持斯坦福阿尔茨海默病中心 (ADRC) 的愿景： 促进和加强阿尔茨海默病多学科和跨学科研究的共享资源 疾病（AD）和相关疾病。核心的结构是为了继续其启用和应用的记录 创新的尖端技术，重点关注大脑衰老和病理过程的多样性 这是 AD 及相关疾病引起的认知障碍和痴呆的基础。的关键功能 神经病理学核心包括诊断专业知识、充当生物存储库、促进创新以及 训练。过去五年来，神经病理学核心已完成 50 多项脑部尸检研究 并在制定和评估国家神经病理学研究指南方面发挥了领导作用 AD的评价。我们已储存了 800 多个组织样本，向当地、 区域、国家和国际研究和联盟，并促进发展和 在转化研究中实施创新技术。通过核心，我们培训了临床医生 以及神经病理学和痴呆相关分子病理学不同学科的科学家 神经退行性疾病。神经病理学核心将通过四个具体目标来履行其使命。这 Core 将为医生和研究人员提供及时和全面的神经病理学评估 描述 AD 及相关疾病的神经病理学特征的综合尸检报告 根据最新的指南和共识诊断标准。它将维持并继续 培养其高度可访问但得到适当保护的脑组织和生物样本库 仔细和纵向地描述患有认知障碍或痴呆的患者，以及认知障碍 正常个体，使用提高和最大化组织和数据质量的方法。在此过程中，核心 将为福尔马林固定、石蜡包埋的组织提供创新的高内涵成像方法 以及冷冻大脑区域，以最大限度地发挥斯坦福 ADRC 存储库和其他大脑的研究价值 全国各地的银行。最后，我们将为医学生和研究生维持丰富的培养环境 跨部门的学生、住院医师、研究员和初级教师教授概念和最先进的技术 推进当前跨学科研究并促进大脑未来进步和见解的技术 衰老和神经退行性疾病。该核心的组织方式是为了最大限度地与系统中的所有其他核心集成。 斯坦福ADRC。它还将继续作为附属 ADRC 和独立机构的支持中心。 通过诊断实践、分子测定和组织共享获得研究奖励。在此过程中，核心和 中心将继续在全国范围内做出贡献，以增进我们对病理特征和 大脑衰老、AD 各阶段以及相关痴呆的病理生理过程。