Neuropathology Core

神经病理学核心

• 批准号: 10176345
• 负责人: Thomas J Montine
• 金额: $ 40.89万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10176345
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Autopsy; Award; Biological Assay; Biological Markers; Brain; Brain region; Clinical Data; Cognitive; Consensus; Country; Data; Dementia; Development; Diagnostic; Discipline; Disease; Environment; Evaluation; Faculty; Formalin; Fostering; Freezing; Future; Guidelines; Image; Impaired cognition; Individual; Interdisciplinary Study; International; Leadership; Medical Students; Methods; Mission; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Outreach Research; Paraffin Embedding; Pathologic; Pathologic Processes; Patients; Physicians; Positioning Attribute; Process; Reporting; Research; Research Personnel; Resource Sharing; Scientist; Specimen; Structure; Techniques; Technology; Time; Tissue Embedding; Tissues; Training; Translational Research; Vision; aging brain; biobank; brain research; brain tissue; data management; data quality; education research; graduate student; imaging approach; innovation; innovative technologies; insight; molecular pathology; neuropathology; repository; research study; statistics

1. SUMMARY (Neuropathology Core) The Neuropathology Core supports the vision of the Stanford Alzheimer’s Disease Center (ADRC) to serve as a shared resource to facilitate and enhance multidisciplinary and interdisciplinary research in Alzheimer’s disease (AD) and related disorders. The Core is structured to continue its track record of enabling and applying innovative cutting-edge technologies with emphasis on brain aging and the diversity of pathologic processes that underlie cognitive impairment and dementia caused by AD and related diseases. The critical functions of the Neuropathology Core include diagnostic expertise, serving as a biorepository, facilitating innovation, and training. Over the past five years, the Neuropathology Core has completed over 50 research brain autopsies and held a leadership position in setting and evaluating national research guidelines for neuropathologic evaluation of AD. We have banked over 800 tissue specimens, contributed data and biospecimens to local, regional, national, and international research studies and consortia, and fostered development and implementation of innovative technologies in translational research. Through the Core, we trained clinicians and scientists from different disciplines in neuropathology and the molecular pathology of dementia-related neurodegenerative diseases. The Neuropathology Core will pursue its mission through four Specific Aims. The Core will provide comprehensive neuropathologic evaluations for physicians and researchers with timely and comprehensive autopsy reports that describe the neuropathologic features of AD and related diseases according to the most current guidelines and consensus diagnostic criteria. It will maintain and continue to grow its highly accessible, but appropriately safeguarded, repository of brain tissue and biospecimens from carefully and longitudinally characterized patients with cognitive impairment or dementia, as well as cognitively normal individuals, using methods that increase and maximize tissue and data quality. In doing so, the Core will empower innovative high-content imaging approaches for both formalin-fixed, paraffin-embedded tissue and for frozen brain regions to maximize the research value of the Stanford ADRC repository and other brain banks around the country. Finally, we will maintain a rich training environment for medical and graduate students, residents, fellows, and junior faculty across departments to teach concepts and state-of-the-art techniques that advance current interdisciplinary research and foster future advances and insights in brain aging and neurodegeneration. The Core is organized to maximize integration with all other Cores in the Stanford ADRC. It also will continue to serve as a hub of support for affiliated ADRCs and independent research awards through diagnostic practices, molecular assays, and tissue sharing. In doing so, the Core and Center will continue to contribute nationally to advance our understanding of the pathologic features and pathophysiologic processes of brain aging, all stages of AD, and related dementias.

1.摘要(神经病理学核心) 神经病理学核心支持斯坦福阿尔茨海默病中心(ADRC)作为 促进和加强阿尔茨海默氏症多学科和跨学科研究的共享资源 疾病(AD)及相关疾病。核心的结构是为了继续其支持和应用的跟踪记录 创新的尖端技术，强调大脑老化和病理过程的多样性 这是阿尔茨海默病和相关疾病导致认知障碍和痴呆症的基础。的关键功能 神经病理学核心包括诊断专业知识，作为生物信息库，促进创新，以及 训练。在过去的五年里，神经病理核心已经完成了50多例脑部尸检研究 并在制定和评估国家神经病理学研究指南方面处于领导地位 对AD的评价。我们已经储存了800多个组织样本，为当地提供了数据和生物标本， 区域、国家和国际研究研究和联合体，并促进发展和 在翻译研究中实施创新技术。通过CORE，我们培训了临床医生 以及来自不同学科的科学家在神经病理学和分子病理学方面与痴呆症相关 神经退行性疾病。神经病理学核心中心将通过四个具体目标来实现其使命。这个 CORE将为医生和研究人员提供全面的神经病理评估， 描述阿尔茨海默病及相关疾病的神经病理特征的综合尸检报告 根据最新的指南和协商一致的诊断标准。它将保持并继续 培养其高度可访问、但受到适当保护的脑组织和生物标本储存库 仔细地和纵向地描述认知障碍或痴呆症患者的特征，以及认知 正常个体，使用提高和最大化组织和数据质量的方法。在此过程中，核心 将为福尔马林固定的石蜡包埋组织提供创新的高含量成像方法 对于冰冻的大脑区域，最大限度地发挥斯坦福ADRC储存库和其他大脑的研究价值 全国各地的银行。最后，我们将为医学和研究生提供丰富的培训环境 跨部门的学生、住院医生、研究员和初级教职员工，教授概念和最新技术 推动当前跨学科研究并促进未来大脑进步和洞察力的技术 衰老和神经退化。核心的组织旨在最大限度地与中的所有其他核心集成 斯坦福大学ADRC。它还将继续作为附属ADRC和独立ADRC的支持中心 通过诊断实践、分子分析和组织共享获得研究奖项。在此过程中，核心和 中心将继续在全国范围内促进我们对病理特征和 脑老化、阿尔茨海默病各阶段及相关痴呆的病理生理过程。