Neuropathology Core

神经病理学核心

• 批准号: 10409745
• 负责人: Thomas J Montine
• 金额: $ 36.56万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10409745
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Autopsy; Award; Biological Assay; Biological Markers; Brain; Brain region; Clinical Data; Cognitive; Consensus; Country; Data; Dementia; Development; Diagnostic; Discipline; Disease; Environment; Evaluation; Faculty; Formalin; Fostering; Freezing; Future; Guidelines; Image; Impaired cognition; Individual; Interdisciplinary Study; International; Leadership; Medical Students; Methods; Mission; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Outreach Research; Paraffin Embedding; Pathologic; Pathologic Processes; Patients; Physicians; Positioning Attribute; Process; Reporting; Research; Research Personnel; Resource Sharing; Scientist; Specimen; Structure; Techniques; Technology; Time; Tissue Embedding; Tissues; Training; Translational Research; Vision; aging brain; biobank; brain research; brain tissue; data management; data quality; diagnostic criteria; education research; graduate student; imaging approach; innovation; innovative technologies; insight; molecular pathology; neuropathology; repository; research study; statistics

1. SUMMARY (Neuropathology Core) The Neuropathology Core supports the vision of the Stanford Alzheimer’s Disease Center (ADRC) to serve as a shared resource to facilitate and enhance multidisciplinary and interdisciplinary research in Alzheimer’s disease (AD) and related disorders. The Core is structured to continue its track record of enabling and applying innovative cutting-edge technologies with emphasis on brain aging and the diversity of pathologic processes that underlie cognitive impairment and dementia caused by AD and related diseases. The critical functions of the Neuropathology Core include diagnostic expertise, serving as a biorepository, facilitating innovation, and training. Over the past five years, the Neuropathology Core has completed over 50 research brain autopsies and held a leadership position in setting and evaluating national research guidelines for neuropathologic evaluation of AD. We have banked over 800 tissue specimens, contributed data and biospecimens to local, regional, national, and international research studies and consortia, and fostered development and implementation of innovative technologies in translational research. Through the Core, we trained clinicians and scientists from different disciplines in neuropathology and the molecular pathology of dementia-related neurodegenerative diseases. The Neuropathology Core will pursue its mission through four Specific Aims. The Core will provide comprehensive neuropathologic evaluations for physicians and researchers with timely and comprehensive autopsy reports that describe the neuropathologic features of AD and related diseases according to the most current guidelines and consensus diagnostic criteria. It will maintain and continue to grow its highly accessible, but appropriately safeguarded, repository of brain tissue and biospecimens from carefully and longitudinally characterized patients with cognitive impairment or dementia, as well as cognitively normal individuals, using methods that increase and maximize tissue and data quality. In doing so, the Core will empower innovative high-content imaging approaches for both formalin-fixed, paraffin-embedded tissue and for frozen brain regions to maximize the research value of the Stanford ADRC repository and other brain banks around the country. Finally, we will maintain a rich training environment for medical and graduate students, residents, fellows, and junior faculty across departments to teach concepts and state-of-the-art techniques that advance current interdisciplinary research and foster future advances and insights in brain aging and neurodegeneration. The Core is organized to maximize integration with all other Cores in the Stanford ADRC. It also will continue to serve as a hub of support for affiliated ADRCs and independent research awards through diagnostic practices, molecular assays, and tissue sharing. In doing so, the Core and Center will continue to contribute nationally to advance our understanding of the pathologic features and pathophysiologic processes of brain aging, all stages of AD, and related dementias.

1.总结（神经病理学核心） 神经病理学核心支持斯坦福大学阿尔茨海默病中心（ADRC）的愿景， 一个共享的资源，以促进和加强多学科和跨学科的研究阿尔茨海默氏症 疾病（AD）和相关病症。核心的结构是为了继续其促进和应用 创新的尖端技术，重点是大脑老化和病理过程的多样性 这是由AD和相关疾病引起的认知障碍和痴呆的基础。关键职能 神经病理学核心包括诊断专业知识，作为生物储存库，促进创新， 训练在过去的五年里，神经病理学核心已经完成了50多个研究性的大脑解剖， 并在制定和评估国家神经病理学研究指南方面担任领导职务。 AD的评价。我们已经储存了800多个组织标本，为当地提供了数据和生物标本， 区域，国家和国际研究和财团，并促进发展， 在转化研究中实施创新技术。通过核心，我们培训临床医生 以及来自不同学科的神经病理学和痴呆相关的分子病理学的科学家， 神经退行性疾病神经病理学核心将通过四个具体目标来实现其使命。的 核心将为医生和研究人员提供全面的神经病理学评估， 描述AD和相关疾病神经病理学特征的全面尸检报告 根据最新指南和共识诊断标准。它将保持并继续 将其高度可及但受到适当保护的脑组织和生物标本储存库从 仔细和纵向特征的认知障碍或痴呆患者，以及认知 正常个体，使用增加和最大化组织和数据质量的方法。在这样做时，核心 将为福尔马林固定、石蜡包埋的组织提供创新的高内涵成像方法， 以及冷冻大脑区域，以最大限度地发挥斯坦福大学ADRC储存库和其他大脑的研究价值。 全国各地的银行。最后，我们将为医学和研究生提供丰富的培训环境， 跨部门的学生、住院医师、研究员和初级教师教授概念和最新技术 技术，推进当前的跨学科研究，促进未来的进步和见解，在大脑 老化和神经退化。核心的组织是为了最大限度地与所有其他核心的集成， 斯坦福大学ADRC。它还将继续作为附属的发展成果中心和独立的 通过诊断实践、分子分析和组织共享来获得研究奖励。在这样做时，核心和 中心将继续在全国范围内做出贡献，以促进我们对病理特征的理解， 脑老化的病理生理过程、AD的所有阶段和相关痴呆。