Neuropath Core
神经病核心
基本信息
- 批准号:10262851
- 负责人:
- 金额:$ 37.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-15 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:Alzheimer&aposs DiseaseAlzheimer&aposs disease modelAlzheimer’s disease biomarkerAnimal ModelAreaBiological MarkersBiological ModelsBiological Specimen BanksBloodBlood VesselsBrainCerebrospinal FluidCerebrumClinicalCollaborationsCollectionCommunitiesConsentConsultationsDNADNA RepositoryDataData SetDevelopmentDiagnosisDiagnosticDiseaseEducationEnrollmentEvaluationFosteringFunctional disorderGoalsHumanIndividualInternetLeadershipLiquid substanceMeasurementMeasuresMentorsMetabolicMetabolic DiseasesMethodsMicroscopyModelingMolecularMulti-Ethnic Study of AtherosclerosisNeurodegenerative DisordersOrganoidsParticipantPathologicPathologyPathway interactionsProceduresProtocols documentationResearchResearch PersonnelResourcesRiskRodentRoleSamplingScientific Advances and AccomplishmentsSenile PlaquesSpecimenSpinal PunctureTechnologyTherapeutic Human ExperimentationTherapeutic StudiesTranslational ResearchUnderrepresented PopulationsUniversitiesVascular DiseasesWashingtonbiological specimen archivesbrain volumeclinical centercohortdata managementdistributed dataeducation researchendophenotypeforesthealth disparityinnovationinter-institutionalneuropathologynext generationnonhuman primatenormal agingnovelnovel markeroperationprogramsrecruitrepositorysample collectionsymposiumtau Proteinstherapeutic targettissue biomarkerstranslational modelvascular risk factorvirtual
项目摘要
Neuropathology Core – Project Summary
The Neuropathology (NP) Core will provide unique resources to support the Wake Forest Alzheimer’s
Disease Research Center (ADRC) focus on transitions from normal aging to MCI, AD, and related disorders,
and the role of metabolic and vascular risk pathways in these transitions. The Core will foster innovative
research in all areas relevant to AD. To accomplish these goals, the Core will provide state-of-the-art
collection, storage, and distribution of brain and other biospecimens, establish neuropathological diagnoses of
decedent Clinical Core (CC) participants, and provide resources and expertise for non-human primate (NHP)
models for pivotal mechanistic and therapeutic research. The NP Core will also contribute to the ADRC theme
of health disparities with a unique program focused on increasing brain donation from underrepresented
groups (URGs). Through these activities, the NP Core will make impactful contributions to many National
Alzheimer’s Project Act (NAPA) Research Milestones, such as supporting deep, longitudinal molecular
endophenotyping of cohorts that include URGs (1A), data and sample sharing (3A, 4D), and development of
the next generation of animal models (4A, B, C).
The NP Core currently maintains a biospecimen repository of DNA, blood, and cerebrospinal fluid (CSF)
from >1,100 well-characterized participants from the ADRC and its affiliated studies. In the coming cycle, we
will continue to archive biospecimens from ADRC CC participants who have received careful metabolic and
vascular characterization. DNA, CSF and blood will be provided to NCRAD, other consortia, and individual
investigators. AD CSF biomarkers (Ab40, Ab42, tau, and p-tau181) are rigorously measured on all participants
who undergo lumbar puncture (LP), and special expertise is available for blood and CSF biomarkers of
metabolic and vascular disease. We continually assess scientific advances in identifying novel blood and CSF
biomarkers of ADRD and will implement these as the field evolves. Further, human protocols for brain, blood
and CSF collection have been applied to NHP models, creating a unique resource with which the AD research
community can conduct pivotal translational research. In the past cycle, we demonstrated that our NHP model
has neuropathologic changes similar to early AD such as amyloid plaques, AD-like CSF Ab42 profiles, cerebral
hypometabolism, and reduced brain volumes. Consultation about NHP and other models (rodent, organoid) will
be available.
In summary, through careful clinico-pathologic analysis of well characterized cohorts, unique biospecimen
repositories, and novel translational models, the NP Core will promote the WF ADRC themes, and provide an
exceptional resource to investigate underlying mechanisms, novel biomarkers, and therapeutic targets that
impact progression from normal aging to MCI and ADRD.
神经病理学核心-项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas J Montine其他文献
Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein
- DOI:
10.1186/1742-2094-4-2 - 发表时间:
2007-01-04 - 期刊:
- 影响因子:10.100
- 作者:
Jinghua Jin;Feng-Shiun Shie;Jun Liu;Yan Wang;Jeanne Davis;Aimee M Schantz;Kathleen S Montine;Thomas J Montine;Jing Zhang - 通讯作者:
Jing Zhang
Thomas J Montine的其他文献
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{{ truncateString('Thomas J Montine', 18)}}的其他基金
Project 2: Particle and brain mapping of CSF proteins using elemental reporters with mass spectrometry
项目 2:使用元素报告仪和质谱法对 CSF 蛋白进行粒子和脑图谱分析
- 批准号:
10359193 - 财政年份:2020
- 资助金额:
$ 37.48万 - 项目类别:
Project 2: Particle and brain mapping of CSF proteins using elemental reporters with mass spectrometry
项目 2:使用元素报告仪和质谱法对 CSF 蛋白进行粒子和脑图谱分析
- 批准号:
10573262 - 财政年份:2020
- 资助金额:
$ 37.48万 - 项目类别:
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