Neuropathology Core

神经病理学核心

• 批准号: 10601059
• 负责人: Thomas J Montine
• 金额: $ 27.05万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601059
• 关键词: Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease patient; Archives; Autopsy; Biological Assay; Biological Markers; Blood; Blood Vessels; Board Certification; Brain; Brain region; Caring; Cataloging; Catalogs; Cell Line; Cells; Cellular biology; Cessation of life; Clinical; Clinical Data; Collaborations; Collection; Communication; Country; DNA; Data; Dementia; Diagnosis; Diagnostic; Disease Progression; Elderly; Elements; Enrollment; Ensure; Evaluation; Family; Freezing; Genetic; Genomics; Goals; Individual; International; Internet; Leadership; Lewy Bodies; Life; Link; Memory; Mission; Molecular; Molecular Analysis; Monitor; Morphology; Neurosciences; Participant; Pathologic; Pathology; Patients; Process; Proteomics; Qualifying; Registries; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Sampling; Services; Specimen; Stem Cell Research; Technology; Time; Tissue Banks; Tissues; Training; Translational Research; Universities; Veins; Wisconsin; blood product; cell bank; cell repository; cohort; data management; experience; induced pluripotent stem cell; innovation; interest; mild cognitive impairment; neuroimaging; neuropathology; normal aging; novel marker; pre-clinical; programs; protein TDP-43; repository; software development; stem cells; symposium; tissue biomarkers; tissue fixing; tool

PROJECT SUMMARY - NEUROPATHOLOGY CORE (CORE D) The mission of the Neuropathology Core at the Wisconsin Alzheimer's Disease Research Center (ADRC) is to: provide detailed characterization of brains from patients with Alzheimer's disease (AD) and other dementias; facilitate scientific and intellectual interactions between the various ADRC cores; and serve as a local and national repository for AD specimens. The Core will continue to facilitate clinical-pathologic and translational research on normal aging, mild cognitive impairment (MCI), AD, and other dementias by providing to Wisconsin ADRC and outside investigators a comprehensive resource of biospecimens, biomarker data, clinical data, and state-of-the-art diagnoses for MCI and AD, vascular, Lewy body, TDP-43, and mixed pathologies, from subjects in the Clinical Core and Wisconsin Registry for Alzheimer's Prevention (WRAP). The Neuropathology Core will generate and assemble critical diagnostic information by combining clinical data (Core B), innovative neuroimaging and biomarker assays (Core G) collected during life with brain autopsy, and morphologic, immunohistochemical, genetic, cell and molecular post-mortem analyses. The Neuropathology Core will also provide access to cutting edge tools (including genomics and proteomics) to enhance AD research on banked, frozen tissue. Additionally, the Core has taken a leadership role in setting up an induced pluripotent stem cells (iPSC) bank, with the aim of providing well-characterized stem cell lines from AD and control patients to investigators throughout the country. The Core will accomplish these goals by 1) collecting and archiving post- mortem frozen and fixed tissue blocks from multiple brain regions on deceased individuals, and ante-mortem CSF, blood, and DNA who are enrolled in the Wisconsin ADRC as well as normal elderly controls; 2) providing state-of-the-art postmortem diagnoses on Clinical Core subjects, collect National Alzheimer's Coordinating Center (NACC) neuropathology data and make the results available to the family, relevant clinicians, qualified researchers, and NACC; 3) distributing ante-mortem and post-mortem biospecimens (brain, CSF, blood products, and DNA) and neuropathologic, genetic, biomarker, and other data to suit the requirements of qualified research projects, both within UW-Madison and for national and international multi-center collaborations; 4) performing genetic and biomarker analyses in support of ADRC and outside investigators; and 5) providing well- characterized iPSC lines to local and national researchers. A flow of services is therefore envisaged whereby Wisconsin ADRC investigators and collaborators are able to obtain unambiguous post-mortem diagnosis, neuropathological data, and tissues from the Neuropathology Core together with comprehensive biomarker data (Biomarker Services) and neuroimaging data (Core G). Finally, the Core will also support advanced molecular and cellular analyses can be performed on tissues by the Biomarker and Cellular and Molecular Neuroscience Services.

项目摘要--神经病理学核心(核心D) 威斯康星州阿尔茨海默病研究中心(ADRC)神经病理学核心的任务是： 提供阿尔茨海默病(AD)和其他痴呆症患者大脑的详细特征； 促进不同ADRC核心之间的科学和智力互动；并作为地方和 AD标本的国家储存库。核心将继续促进临床病理和翻译 威斯康星州对正常衰老、轻度认知障碍、阿尔茨海默病等痴呆的研究 ADRC和外部调查人员拥有生物标本、生物标记物数据、临床数据和 受试者对MCI和AD、血管、路易小体、TDP-43和混合病理的最新诊断 在临床核心和威斯康星州阿尔茨海默氏症预防注册中心(WRAP)。神经病理学的核心意志 通过结合临床数据生成和集合关键诊断信息(核心B)，创新 神经成像和生物标记物分析(核心G)在生活中收集的大脑尸检，和形态， 免疫组织化学、遗传、细胞和分子尸检分析。神经病理核心也将 提供尖端工具(包括基因组学和蛋白质组学)，以加强对银行的AD研究， 冰冻组织。此外，核心在建立诱导多能干细胞方面发挥了领导作用 (IPSC)银行，目的是为AD患者和对照患者提供具有良好特性的干细胞系 全国各地的调查人员。核心将通过以下方式实现这些目标：1)收集和归档邮件- 死者多个脑区的冷冻和固定组织块，以及死前 在威斯康星州ADRC登记的脑脊液、血液和DNA以及正常的老年人对照组；2)提供 最新的临床核心对象尸检诊断，收集全国阿尔茨海默氏症协调 中心(NACC)的神经病理数据，并将结果提供给家庭、相关临床医生、合格的 研究人员和NACC；3)分布死前和死后的生物标本(脑、脑脊液、血液 产品，以及DNA)和神经病理、遗传、生物标志物等数据，以适应合格的要求 威斯康星大学麦迪逊分校内以及国内和国际多中心合作的研究项目；4) 进行遗传和生物标记分析，以支持ADRC和外部调查人员；以及5)提供良好的 向当地和国家研究人员描述了IPSC系列。因此，设想了服务流，从而 威斯康星州ADRC的调查人员和合作者能够获得明确的尸检诊断， 神经病理数据和神经病理核心组织以及全面的生物标记物数据 (生物标志物服务)和神经成像数据(核心G)。最后，核心还将支持先进的分子 细胞分析可以通过生物标记物和细胞和分子神经科学对组织进行 服务。