Fred Hutchinson Cancer Research Center Lung SPORE

项目摘要/摘要--总体 弗雷德·哈奇肺孢子包括四个创新项目，三个支持性核心，以及所需的 发展研究计划和职业提升计划。我们利用了以下优势 研究人员和我们的中心解决阻碍肺部有意义改善的三个关键障碍 癌症存活率：促进肺结节评估对肺癌的早期发现和 筛查，小细胞肺癌(SCLC)缺乏有效的治疗方法，以及 非小细胞肺癌(NSCLC)患者转向基于免疫的新疗法。为了克服这些障碍， 我们提出了以下四个方案：1)靶向中性粒细胞谱系以增强免疫检查点 抑制物在非小细胞肺癌中的作用，2)靶向新抗原用于肺癌免疫治疗，3)鉴定 小细胞肺癌对LSD1抑制敏感性的决定因素，以及4)肺结节的危险分层 使用血浆和成像生物标记物的CT成像检测。这些项目将由一个 管理核心，生物统计和生物信息学核心(BBC)，以及组织病理学和生物显微镜 核心(HBC)。

Project Summary/Abstract – Overall The Fred Hutch Lung SPORE consists of four innovative projects, three supportive cores, and the required Developmental Research Program and Career Enhancement Program. We have leveraged the strengths of the investigators and our Center to tackle three critical barriers precluding meaningful improvements in lung cancer survival rates: facilitation of pulmonary nodule evaluation for lung cancer early detection and screening, lack of effective therapies for small cell lung cancer (SCLC), and the sub-optimal response rates of non-small cell lung cancer (NSCLC) patients to novel immune-based therapies. To overcome these barriers, we propose the following four projects: 1) Targeting the Neutrophil Lineage to Enhance Immune Checkpoint Inhibitor Efficacy in NSCLC, 2) Targeting Neoantigens for Lung Cancer Immunotherapy, 3) Identifying Determinants of Sensitivity to LSD1 Inhibition in SCLC, and 4) Risk Stratification for Pulmonary Nodules Detected by CT Imaging Using Plasma and Imaging Biomarkers. These projects will be supported by an Administrative Core, a Biostatistics and Bioinformatics Core (BBC), and a Histopathology and Biospecimen Core (HBC).