Fred Hutchinson Cancer Research Center Lung SPORE

项目概要/摘要-总体 Fred Hutch Lung SPORE包括四个创新项目，三个支持核心，以及所需的 发展研究计划和职业发展计划。我们充分利用了 研究人员和我们的中心，以解决三个关键的障碍，阻止有意义的改善肺 癌症存活率：促进肺结节评估，以早期发现肺癌， 筛查，缺乏有效的小细胞肺癌（SCLC）治疗方法， 非小细胞肺癌（NSCLC）患者的新的免疫为基础的治疗。为了克服这些障碍， 我们提出了以下四个项目：1）靶向神经元谱系以增强免疫检查点 抑制剂在NSCLC中的功效，2）靶向肺癌免疫治疗的新抗原，3）鉴定 SCLC中对LSD 1抑制敏感性的决定因素，以及4）肺结节的风险分层 通过使用血浆和成像生物标志物的CT成像检测。这些项目将得到一个 管理核心，生物统计学和生物信息学核心（BBC），以及生物学和生物标本 核心（HBC）。

Project Summary/Abstract – Overall The Fred Hutch Lung SPORE consists of four innovative projects, three supportive cores, and the required Developmental Research Program and Career Enhancement Program. We have leveraged the strengths of the investigators and our Center to tackle three critical barriers precluding meaningful improvements in lung cancer survival rates: facilitation of pulmonary nodule evaluation for lung cancer early detection and screening, lack of effective therapies for small cell lung cancer (SCLC), and the sub-optimal response rates of non-small cell lung cancer (NSCLC) patients to novel immune-based therapies. To overcome these barriers, we propose the following four projects: 1) Targeting the Neutrophil Lineage to Enhance Immune Checkpoint Inhibitor Efficacy in NSCLC, 2) Targeting Neoantigens for Lung Cancer Immunotherapy, 3) Identifying Determinants of Sensitivity to LSD1 Inhibition in SCLC, and 4) Risk Stratification for Pulmonary Nodules Detected by CT Imaging Using Plasma and Imaging Biomarkers. These projects will be supported by an Administrative Core, a Biostatistics and Bioinformatics Core (BBC), and a Histopathology and Biospecimen Core (HBC).