Emotion Dysregulation and Sleep-Time Masticatory Muscle Activity in Sleep Bruxism

项目摘要 这个建议的总体目标是研究情绪调节（ER）在睡眠磨牙症中的作用 （SB）。SB的特征在于睡眠期间咀嚼肌活动（MMA）的极端水平， 表现为磨牙或咬牙。SB可在近端导致牙齿损伤、口面疼痛， 睡眠受损;易患关节退行性疾病;并最终出现 更广泛的神经退行性疾病的临床前体征。然而，迄今为止， SB的治愈性治疗和SB的潜在机制还不清楚。为了填补这一空白， 我们提出了一个整合的神经生物学框架，重点关注受损的参与， 我们将测试这个框架的基本原则，通过解决 四个主要目标：目标1测试个体在ER期间任务相关神经激活的差异， SB（SB+）与匹配对照（SB-）。目的2研究了任务- SB+和SB-睡眠期间ER与MMA相关的前额叶皮层激活。目标3 研究是否可以在SB+中实验性地操纵ER期间的神经激活。目标4 通过调查是否更有效的任务相关的前额叶皮层， 在SB+中，ER期间的激活通过减少任务相关的情绪而减少睡眠期间的MMA 激活杏仁核100 SB+和50 SB−将根据多导睡眠图研究定义 诊断标准将评估ER任务期间感兴趣的大脑区域的功能激活 并在睡眠期间进行MMA的动态监测。在SB+中，ER将通过实验 操作和影响将评估在脑功能激活的兴趣区域， ER任务以及在睡眠期间的MMA。拟议的工作是一个图解翻译的一部分， 研究议程，以开发新的有效的疗法，目标ER过程，以减轻情感， 睡眠和压力引起的神经退行性疾病。

PROJECT SUMMARY The overall goal of this proposal is to examine the role of emotion regulation (ER) in sleep bruxism (SB). SB is characterized by extreme levels of masticatory muscle activity (MMA) during sleep, expressed as teeth grinding or clenching. SB may proximally lead to tooth damage, orofacial pain, and impaired sleep; predispose to the development of joint degenerative disorders; and ultimately present a preclinical sign for a broader range of neurodegenerative disorders. However, there is as yet no curative treatment for SB, and the mechanisms underlying SB are not well understood. To fill this gap, we propose an integrative neurobiological framework that focuses on the involvement of impaired downregulation of wake-time emotion in SB. We will test basic tenets of this framework by addressing four major aims: Aim 1 tests differences in task-related neural activation during ER in individuals with SB (SB+) vs. matched controls (SB−). Aim 2 investigates direct and indirect pathways associating task- related prefrontal cortex activatin during ER with MMA during sleep among SB+ and SB−. Aim 3 examines whether neural activation during ER can be experimentally manipulated in SB+. Aim 4 addresses causal mechanisms by investigating whether more efficient task-related prefrontal cortex activation during ER decreases MMA during sleep in SB+ through decreased task-related emotional activation of the amygdala. 100 SB+ and 50 SB− will be defined based on polysomnographic research diagnostic criteria. Functional activations of brain regions of interest during an ER task will be assessed and ambulatory monitoring of MMA during sleep will be conducted. In SB+, ER will be experimentally manipulated and effects will be assessed on functional activations of brain regions of interest during the ER task as well as on MMA during sleep. The proposed work is part of a programatic translational research agenda to develop novel effective therapies that target ER processes to alleviate affective, sleep, and stress-induced neurodegenerative disorders.