Emotion Dysregulation and Sleep-Time Masticatory Muscle Activity in Sleep Bruxism

睡眠磨牙症中的情绪失调和睡眠时咀嚼肌活动

• 批准号: 9287723
• 负责人: JAMES J GROSS
• 金额: $ 48.29万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-13 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9287723
• 关键词: Address; Affective; Ambulatory Monitoring; Amygdaloid structure; Brain region; Clinical; Cues; Data; Degenerative Disorder; Development; Diagnostics Research; Disease; Down-Regulation; Emotional; Emotions; Enrollment; Functional Magnetic Resonance Imaging; Generations; Goals; Impairment; Individual; Joints; Laboratories; Lead; Literature; Masticatory muscles; Measures; Mood Disorders; Movement Disorders; Neurobiology; Neurodegenerative Disorders; Orofacial Pain; Pain; Participant; Pathway interactions; Patient Self-Report; Polysomnography; Prefrontal Cortex; Process; Randomized; Research; Role; Sleep; Sleep Bruxism; Sleep Disorders; Stress; Temporomandibular Joint; Testing; Time; Tooth structure; Translational Research; Work; affective neuroscience; base; blood oxygen level dependent; bone; curative treatments; effective therapy; emotion dysregulation; emotion regulation; interest; negative affect; novel; pre-clinical; psychosocial development; relating to nervous system; response; targeted imaging; targeted treatment; therapy development

PROJECT SUMMARY The overall goal of this proposal is to examine the role of emotion regulation (ER) in sleep bruxism (SB). SB is characterized by extreme levels of masticatory muscle activity (MMA) during sleep, expressed as teeth grinding or clenching. SB may proximally lead to tooth damage, orofacial pain, and impaired sleep; predispose to the development of joint degenerative disorders; and ultimately present a preclinical sign for a broader range of neurodegenerative disorders. However, there is as yet no curative treatment for SB, and the mechanisms underlying SB are not well understood. To fill this gap, we propose an integrative neurobiological framework that focuses on the involvement of impaired downregulation of wake-time emotion in SB. We will test basic tenets of this framework by addressing four major aims: Aim 1 tests differences in task-related neural activation during ER in individuals with SB (SB+) vs. matched controls (SB−). Aim 2 investigates direct and indirect pathways associating task- related prefrontal cortex activatin during ER with MMA during sleep among SB+ and SB−. Aim 3 examines whether neural activation during ER can be experimentally manipulated in SB+. Aim 4 addresses causal mechanisms by investigating whether more efficient task-related prefrontal cortex activation during ER decreases MMA during sleep in SB+ through decreased task-related emotional activation of the amygdala. 100 SB+ and 50 SB− will be defined based on polysomnographic research diagnostic criteria. Functional activations of brain regions of interest during an ER task will be assessed and ambulatory monitoring of MMA during sleep will be conducted. In SB+, ER will be experimentally manipulated and effects will be assessed on functional activations of brain regions of interest during the ER task as well as on MMA during sleep. The proposed work is part of a programatic translational research agenda to develop novel effective therapies that target ER processes to alleviate affective, sleep, and stress-induced neurodegenerative disorders.

项目总结 该提案的总体目标是研究情绪调节(ER)在睡眠磨牙症中的作用 (某人)SB的特征是睡眠时咀嚼肌肉活动(MMA)的极端水平， 表现为磨牙或咬牙切齿。SB可能会导致牙齿损伤、口腔疼痛以及 睡眠受损；易患关节退行性疾病；并最终出现 更广泛的神经退行性疾病的临床前体征。然而，到目前为止还没有 对某人的根治方法和潜在的机制还不是很清楚。为了填补这一空白， 我们提出了一个综合的神经生物学框架，重点关注受损患者的参与 降低某人清醒时的情绪。我们将通过以下方式测试此框架的基本原则 四个主要目标：目标1测试在ER过程中任务相关神经激活的差异 Sb(Sb+)组与对照组(Sb−)。目标2研究了与任务相关的直接和间接路径- Sb+和Sb−患者睡眠时ER与MMA相关的前额叶皮质激活。目标3 检查内质网期间的神经激活是否可以在Sb+中进行实验操作。目标4 通过研究更有效的任务相关前额叶皮质来解决因果机制 ER期间的激活通过减少与任务相关的情绪降低了SB+患者睡眠期间的MMA 杏仁核的激活。将根据多导睡眠图研究定义100 Sb+和50 Sb− 诊断标准。将评估在ER任务中感兴趣的大脑区域的功能激活 并在睡眠期间对MMA进行动态监测。在SB+中，ER将试验性地 将评估对大脑感兴趣区域的功能激活的影响 ER任务以及睡眠中的MMA。拟议的工作是一项程序性翻译的一部分 研究议程，以开发针对ER过程的新的有效疗法来缓解情感障碍， 睡眠，以及压力引起的神经退行性疾病。