Genomic Resource Grant for the PhenX Toolkit - expansion and sustainabilityPhenX Supplement for COVID-19 Research

PhenX 工具包的基因组资源资助 - 扩展和可持续性PhenX 针对 COVID-19 研究的补充

• 批准号: 10179036
• 负责人: Carol Marie Hamilton
• 金额: $ 95.5万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10179036
• 关键词: Administrative Supplement; Adolescent; All of Us Research Program; Area; Award; Awareness; Bioinformatics; Biomedical Research; Brain; COVID-19; Catalogs; Child Health; Clinical Research; Collaborations; Collection; Common Data Element; Communities; Community Outreach; Complex; Consensus; Data; Data Collection; Data Pooling; Development; Disease; Enrollment; Ensure; Epidemiologist; Etiology; Genetic Diseases; Genomics; Grant; International; Intervention; Logical Observation Identifiers Names and Codes; Longitudinal Studies; Measurement; Measures; Mental Health; Meta-Analysis; National Human Genome Research Institute; Outcome; Phenotype; Process; Protocols documentation; Recommendation; Reproducibility of Results; Research; Research Design; Research Methodology; Research Personnel; Resources; Science; Sickle Cell Anemia; Social Distance; Source; Symptoms; Text; Tobacco; Translational Research; U-Series Cooperative Agreements; United States; United States National Library of Medicine; Vaccines; base; behavioral/social science; bioinformatics tool; cognitive development; crowdsourcing; data dictionary; data harmonization; data interoperability; data sharing; database of Genotypes and Phenotypes; electronic data; genome wide association study; genome-wide analysis; improved; medical specialties; member; multidisciplinary; recruit; response; social science research; standard measure; tool; usability; volunteer; working group

PROJECT SUMMARY/ABSTRACT Biomedical science in the 21st century is a multidisciplinary and data-intensive enterprise that relies on clear specification of research methods and results. The reproducibility of findings and the meta-analysis of pooled data from disparate sources are both catalyzed by standard approaches to acquiring and representing data. In this context, the PhenX (consensus measures for Phenotypes and eXposures) Toolkit (https://www.phenxtoolkit.org/) is an increasingly valuable catalog of standard measures and bioinformatics tools that help investigators improve the quality and consistency of data collection and identify opportunities for collaborative research. Measures in the PhenX Toolkit are selected by working groups (WGs) of domain experts using a consensus process and criteria established by the PhenX Steering Committee (SC). Since its launch, PhenX has expanded beyond standard measures for genome-wide association studies (GWAS) of common, complex diseases to include domains such as Rare Genetic Conditions, Sickle Cell Disease, and Tobacco Regulatory Research. The specific aims of the proposed Administrative Supplement “PhenX Measures for COVID-19” are as follows: Specific Aim 1: Develop COVID-19 Core and Specialty collections. Specific Aim 2: Develop features and tools for the COVID-19 page. Specific Aim 3: Establish PhenX measurement protocols for COVID-19 outcomes. The crowd-sourcing approach defined here will rapidly establish COVID-19 Core and Specialty Collections and raise awareness of the COVID-19 measurement protocols available in the PhenX Toolkit.Body Text (no more than 30 lines)

项目摘要/摘要 21世纪的生物医学科学是一项多学科、数据密集型的事业，它依赖于 说明研究方法和结果。POOLED研究结果的重复性和荟萃分析 来自不同来源的数据都由获取和表示数据的标准方法催化。 在这方面，PhenX(表型和暴露的共识测量)工具包 (https://www.phenxtoolkit.org/)是一个越来越有价值的标准测量和生物信息学目录 帮助调查人员提高数据收集的质量和一致性并发现机会的工具 用于合作研究。PhenX工具包中的措施由领域的工作组(WG)选择 使用PhenX指导委员会(SC)制定的协商一致进程和标准的专家。自.以来 PhenX的推出已经超出了全基因组关联研究(GWAS)的标准测量范围 常见的、复杂的疾病包括罕见的遗传疾病、镰刀细胞病、 和烟草监管研究。 建议的行政副刊《新冠肺炎芬芳措施》的具体目的如下 具体目标1：发展新冠肺炎核心特色馆藏。具体目标2：开发特色 以及新冠肺炎页面的工具。具体目标3：建立新冠肺炎的PhenX测量方案 结果。 这里定义的众包方式将迅速建立新冠肺炎核心和专业集合 并提高对PhenX工具包中提供的新冠肺炎测量协议的认识。正文(否 超过30行)